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Annual Meeting 2014

Meeting Program

(Information is subject to change.)

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Tuesday, July 1, 2014

   

7:00 AM–6:00 PM

REGISTRATION – Grand Ballroom Foyer

 

 

7:00 AM–6:00 PM

SPEAKER READY ROOM OPEN – Grand Ballroom Foyer

   
6:30 AM–7:00 AM SUNRISE MINI COURSE: COFFEE AND CONTINENTAL BREAKFAST – Grand Ballroom A
   
7:00 AM–8:00 AM DINE WITH A TERATOLOGY AMBASSADOR – Juniper
(Advance Signup Required)
   

7:00 AM–8:30 AM

SUNRISE MINI COURSE – Grand Ballroom A
(Separate Registration Required)

  Applications of Computational Toxicology in the Study of Birth Defects
  Organized by the Education Committee, Chairperson, Carolyn Kapron, Trent University
   
7:00 AM–7:45 AM   The Use of Computational Toxicology to Identify Reproductive and Developmental Outcomes of Concern
    George P. Daston, Procter & Gamble Company
     
7:45 AM–8:30 A   How Are Computational Toxicology Methods Used to Prioritize Compounds for Testing?
    Thomas B. Knudsen, National Center for Computational Toxicology, US EPA
   
8:30 AM–9:00 AM SPECIAL LECTURE (JOINT WITH NBTS) – Grand Ballroom E
  Fetal Alcohol Syndrome (L5)
  Chairperson: Christina D. Chambers, University of California, San Diego
  Lecturer: Kenneth Lyons Jones, University of California, San Diego and MotherToBaby
   

9:00 AM–12:00 Noon

TESTICULAR DYSGENESIS SYNDROME SYMPOSIUM – Grand Ballroom E

 

Chairpersons: Barbara F. Hales, McGill University and Thomas B. Knudsen, National Center for Computational Toxicology, US EPA

   
9:00 AM–9:15 AM   Introduction
     
9:15 AM–9:45 AM S19 Genetic and Environmental Regulation of External Genital Development
    Martin J. Cohn, Howard Hughes Medical Institute and University of Florida
     
9:45 AM–10:15 AM S20 Cryptorchidism Susceptibility in Pediatric Patients and in Animal Models
    Julia S. Barthold, Nemours/Alfred I. duPont Hospital for Children
     
10:15 AM–10:30 AM   Break
     
10:30 AM–11:00 AM S21 Hypospadias: An Overview of Risk Factors and Etiologies
    Suzan L. Carmichael, Stanford University)
     
11:00 AM–11:30 AM S22 Computational Embryology and Predictive Toxicology of Hypospadias
    Maxwell C. K. Leung, National Center for Computational Toxicology, US EPA
     
11:30 AM–12:00 Noon S23 3-D In Vitro Models and Systems Biology: The Phthalate Syndrome As a Case Example
    Elaine M. Faustman, University of Washington
   
12:00 Noon–1:30 PM STUDENT AND POSTDOCTORAL LUNCH WORKSHOP – Grand Ballroom A
  (Advance Registration Required)
  Building a Successful Career in Developmental and Reproductive Toxicology: Part 2 (W2)
  Chairpersons: Christine P. Curran, Northern Kentucky University and Jeffery H. Charlap, WIL Research
   
12:00 Noon–12:15 PM   Introduction
     
12:15 PM–12:35 PM   Beyond the Bench: What Skills are Needed for Next-Gen Developmental and Reproductive Toxicology?
    Nisha Sipes, US Environmental Protection Agency
     
12:35 PM–12:55 PM   Using Good Laboratory Practices to Get Great Data
    Jeffrey H. Charlap, WIL Research
     
12:55 PM–1:15 PM   Integrative Thinking
    Reza J. Rasoulpour, The Dow Chemical Company
     
1:15 PM–1:30 PM   Panel Discussion
   
12:00 Noon–1:30 PM LUNCH ON YOUR OWN
   
1:30 PM – 2:30 PM TS/ETS EXCHANGE LECTURE – Grand Ballroom E
  Is Lack of Mandatory Folic Acid Fortification Public Health Malpractice?
 

Chairpersons: Paul C. Barrow, F.Hoffmann-La Roche Ltd. and Susan L. Makris, US Environmental Protection Agency

 


European Teratology Society:
The Impact of Spina Bifida on Individuals, Families and Society (L6)
Margo L. Whiteford, NHS Greater Glasgow and Clyde

Teratology Society: Accelerating the Pace of Preventing Spina Bifida F and Anencephaly F (L7)
Godfrey P. Oakley Jr., Emory University  

   

2:30 PM–5:30 PM

GRANT OFFICERS ROUNDTABLE – Grand Ballroom E

  Moderator: Jason Hansen, Emory University and Xiaoqin Ye, University of Georgia
Panelists: Richard L. Callan, US Environmental Protection Agency; A. Tyl Hewitt, Eunice Kennedy Shriver National Institute of Child Health and Human Development; Susan E. Maier, Office of Research on Women's Health, NIH; Thaddeus T. Schug, National Institute of Environmental Health Sciences; and Edward R.B. McCabe, March of Dimes Foundation.
   
2:30 PM–5:30 PM PLATFORM SESSION 4 – Grand Ballroom A
  Epidemiology and Clinical Teratology
  Chairpersons: Suzan L. Carmichael, Stanford University and James L. Mills, Eunice Kennedy Shriver National Institute of Child Health and Human Development
   
2:30 PM–2:45 PM   Introduction
     
2:45 PM–3:00 PM 25 Disease Severity and Preterm Delivery in Women with Rheumatoid Arthritis: The Autoimmune Diseases in Pregnancy Project
   

Bharti B, Kopald D, Yan J, Johnson D, Chambers C. University of California, San Diego, Department of Pediatrics, Division of Dysmorphology-Teratology, La Jolla, CA, United States.

     
3:00 PM–3:15 PM 26 Racial Disparity in Birth Defects: Who Has Higher Risk?
   

Ibrahim A1, Tran T2,3, Johnston J2, Richmond N2,3, Pierce D2, Berry S2,3. 1Tulane University School of Public Health & Tropical Medicine, New Orleans, LA, United States, 2Louisiana DHH OPH Children and Youth with Special Health Needs Program, New Orleans, LA, United States, 3LSUHSC School of Medicine, Department of Pediatrics, New Orleans, LA, United States.

     
3:15 PM–3:30 PM 27 Novel Copy Number Variants in a Population-Based Investigation of Heterotaxy-Associated Congenital Heart Disease
   

Rigler S1,2, Kay D3, Sicko R3, Fan R2, Liu A2, Caggana M3, Browne M3, Druschel C3, Romitti P4, Brody L5, Mills J2. 1Naval Medical Center Portsmouth, Portsmouth, VA, United States, 2NICHD, NIH, Bethesda, MD, United States, 3New York State Department of Health, Albany, NY, United States, 4University of Iowa, Iowa City, IA, United States, 5NHGRI, NIH, Bethesda, MD, United States.

     
3:30 PM–3:45 PM 28 Quantifying the "Anticonvulsant Face"
   

Nasri HZ1, Deutsch CK2, Holmes LB1. 1The Medical Genetics Unit at MassGeneral Hospital for Children, Boston, MA, United States, 2Eunice Kennedy Shriver Center, Boston, MA, United States.

     
3:45 PM–4:00 PM   Break
     
4:00 PM–4:15 PM 29 Oral Corticosteroid Use during Pregnancy and Risk for Preterm Birth: A Prospective Cohort Study
    Palmsten K, Johnson DL, Luo Y, Torres CL, Chambers CD. University of California, San Diego, La Jolla, CA, United States.
     
4:15 PM–4:30 PM 30 Linkage of Prescription Data to Congenital Anomaly Registers to Improve Information on Maternal Medication Use: A EUROmediCAT Study
   

De Jonge L1, Jordan S2, Tucker D3, Thayer D4, Pierini A5, Gini R6, Garne E7, Hansen AV7,8, Neville AJ9, Puccini A10, Bakker MK1,11. 1University Medical Center Groningen, Department of Genetics, Groningen, Netherlands, 2Department of Nursing, College of Human and Health Sciences, Swansea University, Swansea, Wales, United Kingdom, 3CARIS, Public Health Wales, Swansea, Wales, United Kingdom, 4Centre for Health Information, Research and Evaluation, Swansea University, Swansea, Wales, United Kingdom, 5Institute of Clinical Physiology, National Research Council (IFC-CNR), Pisa, Italy, 6Agenzia Regionale di Sanità Della Toscana, Florence, Italy, 7Paediatric Department, Hospital Lillebaelt, Kolding, Denmark, 8Department of Public Health, University of Copenhagen, Copenhagen, Denmark, 9IMER (Emilia Romagna Registry of Birth Defects), Azienda Ospedaliero-Universitaria di Ferrara, Ferrara, Italy, 10Drug Policy Service, Emilia Romagna Region Health Authority, Bologna, Italy, 11Department of Obstetrics & Gynecology, University Medical Center Groningen, Groningen, Netherlands.

     
4:30 PM–4:45 PM 31 The Relationship of Sociodemographic and Hispanic Acculturation Factors with Isolated Anotia/Microtia
   

Hoyt AT1, Canfield MA1, Shaw GM2, Waller DK3, Polen KD4, Ramadhani T5, Anderka M6, Scheuerle AE7. 1Texas Department of State Health Services, Birth Defects Epidemiology & Surveillance Branch, Austin, TX, United States, 2Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, United States, 3University of Texas Health Science Center at Houston School of Public Health, Houston, TX, United States, 4National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, United States, 5Division of Research and Analysis, Texas Education Agency, Austin, TX, United States, 6Massachusetts Department of Public Health, Boston, MA, United States, 7Tesserae Genetics, Dallas, TX, United States.

     
4:45 PM–5:00 PM 32 Early Pregnancy Agricultural Pesticide Exposures and Risk of Gastroschisis among Offspring in the San Joaquin Valley of California
   

Shaw GM1, Yang W1, Wolff C2, Roberts E3, Kegley SE4, Padula A1, English PB5, Carmichael SL1. 1Stanford University, Stanford, CA, United States, 2Lobo Geo, LLC, Alameda, CA, United States, 3Public Health Institute, Oakland, CA, United States, 4Pesticide Research Institute, Berkeley, CA, United States, 5California Department of Public Health, Richmond, CA, United States.

     
5:00 PM–5:15 PM 33 Math Dysfunction in Young Adults Exposed Prenatally to Alcohol: 20-Year Follow-Up
   

Coles CD, Kable JA, Lynch ME, Goldstein F. Emory University School of Medicine, Atlanta, GA, United States.

     
5:15 PM–5:30 PM 34 Ovarian Stimulation Use, including Clomiphene Citrate, and Intrauterine Insemination Use and the Risk of Multiplicity and Major Congenital Malformations: A Meta-Analysis
   

Chaabane S1,2, Blais L2,3, Fraser W4,5, Bissonnette F9,5, Monnier P6,7, Tan S-L6,7, Trasler J7,8, Bérard A1,2. 1Research Center, CHU Ste-Justine, Montreal, QC, Canada, 2Faculty of Pharmacy, University of Montreal, Montreal, QC, Canada, 3Research Center, Sacré-Coeur Hospital, Montreal, QC, Canada, 4Department of Obstetrics and Gynecology, CHU Ste-Justine, Montreal, QC, Canada, 5Faculty of Medicine, University of Montreal, Montreal, QC, Canada, 6MUHC University Reproductive Center, Department of Obstetrics and Gynecology, Royal Victoria Hospital, Montreal, QC, Canada, 7Faculty of Medicine, McGill University, Montreal, QC, Canada, 8Montreal Children’s Hospital Research Institute, Montreal, QC, Canada, 9OVO Fertility Clinic, CHUM, Montreal, QC, Canada.

 

 

5:30 PM–7:30 PM POSTER SESSION 2 AND EXHIBITS OPEN – Evergreen Ballroom
 

Teratology Society Posters: P27–P61
Chairpersons: Jane F. Rasco, University of Alabama and Meredith S. Rocca, Janssen Research and Development

Click Here to Browse Posters

Poster Session 2
(Presenter designated by underlined author.)

P27
Katzman PJ. University of Rochester Medical Center, Rochester, NY, United States. Nonsyndromic Complex Congenital Heart Disease in a Second Trimester Abortus after First Trimester Maternal Buproprion Usage

P28
Toufaily MH1,2, Westgate M-N1,2, Holmes LB1,2. 1Medical Genetics, MassGeneral Hospital for Children, Boston, MA, United States, 2Department of Newborn Medicine, Brigham and Women’s Hospital, Boston, MA, United States. Triploidy: Variations in Phenotype

P29
Beniwal S, Tran T, Johnston J, Mohren T. Louisiana Office of Public Health, New Orleans, LA, United States. Orofacial Cleft: Increased Risk of Hearing Loss

P30
Sheng Y1, Tran T2. 1Louisiana Office of Public Health, New Orleans, LA, United States, 2Tulane University, New Orleans, LA, United States. Are Septal Defects Associated with Hearing Loss?

P31
Parikh YS, Rengasamy P, Clements J. Central Michigan University College of Medicine, Mt. Pleasant, MI, United States. Prevalence Rates of Birth Defects in the State of Michigan

P32
Ren A1,2, Wang B1,2, Jin L1,2, Zhang Y1,2, Liu J1,2, Zhang L1,2, Li Z1,2, Wang L1,2, Ye R1,2. 1Institute of Reproductive and Child Health, Peking University, Beijing, China, 2Key Laboratory of Reproductive Health, Ministry of Health, Beijing, China. Concentrations of Polycyclic Aromatic Hydrocarbons, Levels of Macromolecular Oxidative Damage Markers in Maternal Serum, and Risk of Fetal Neural Tube Defects

P33
Dawson AL, Riehle-Colarusso T, Reefhuis J, Arena JF. Centers for Disease Control and Prevention, Atlanta, GA, United States. Maternal Exposure to Methotrexate and Birth Defects: A Population-Based Study

P34
Blais L1,2, Beauchesne M-F1,3, Kettani F1,2, Lemière C1,2, Forget A1,2. 1Université de Montréal, Montréal, QC, Canada, 2Hôpital du Sacré-Coeur de Montréal, Montréal, QC, Canada, 3CHUS, Sherbrooke, QC, Canada. Maternal Asthma and the Prevalence of Major Congenital Malformations: Is Drug Insurance Status an Effect Modifier?

P35
Parker RM, Baxter GE. Huntingdon Life Sciences, East Millstone, NJ, United States. Control Data from Sprague-Dawley Rat Juvenile Toxicity Studies: Part 1

P36
Baxter GE, Parker RM. Huntingdon Life Sciences, East Millstone, NJ, United States. Control Data from Sprague-Dawley Rat Juvenile Toxicity Studies: Part 2

P37
Boghossian N1, Sicko R2, Kay D2, Rigler S3, Yeung E1, Druschel C5, Romitti P4, Browne M5, Fan R1, Liu A1, Brody L6, Mills J1. 1Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, United States, 2Wadsworth Center, New York State Department of Health, Albany, NY, United States, 3Naval Medical Center Portsmouth, Portsmouth, VA, United States, 4University of Iowa, Iowa City, IA, United States, 5Congenital Malformations Registry, New York State Department of Health, Albany, NY, United States, 6National Human Genome Research Institute, Bethesda, MD, United States. Novel Copy Number Variants in a Population-Based Investigation of Prune Belly Syndrome

P38
Halladay A1, Escher J3,4, Dion K2. 1Autism Speaks, New York, NY, United States, 2College of the Holy Cross, Worcester, MA, United States, 3Escher Fund for Autism, San Jose, CA, United States, 4Autism Society of San Francisco, San Francisco, CA, United States. Exploring Multigenerational and Transgenerational Epigenetic Inheritance Due to Environmental Exposures: A Literature Review

P39
Ibarra-Ramírez M, Campos-Acevedo D, Gómez-Puente V, Hernández-Almaguer D, Martínez Garza LE. Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico. A Novel Association between Mosaic Variegated Aneuploidy Syndrome (MVAS) and Holoprosencephaly

P40
Sipes NS1, Knudsen TB1, Firestone MP2, Cohen-Hubal E3. 1National Center for Computational Toxicology, US EPA, Research Triangle Park, NC, United States, 2Office of Children’s Health Protection, US EPA, Washington, DC, United States, 3Chemical Safety for Sustainability Research Program, US EPA, Research Triangle Park, NC, United States. EPA’s Children’s Environmental Health Roadmap: Applying the 21st Century Vision to Prenatal Development

P41
Philbrook NA, Winn LM. Queen’s University, Kingston, ON, Canada. In Utero Benzene Exposure Does Not Affect Levels of Methylated DNA or Histone Modifications in CD-1 Mouse Fetal Livers

P42
Fadel RA1,2, Hussen HH2, El-Badawi MGY2,3, Salem AA1,2. 1Arabian Gulf University, Manama, Bahrain, 2Suez Canal University, Ismailia, Egypt, 3Moi University, Moi, Kenya. Paradoxical Effects of Melatonin on the Teratogenicity of Alcohol in 12-Day Rat Embryos

P43
Lefebvre M, Cox S, Davis L, Bao Y, Ramonell KM. University of Alabama, Tuscaloosa, AL, United States. Reproductive Effects of Iron Oxide Nanoparticles in the Model Plant Arabidopsis

P44
Kappeler CJ1, Stump DG1, Kopp CA1, Sloter ED1, Coder PS2. 1WIL Research, Ashland, OH, United States, 2Batelle, Columbus, OH, United States. A Model to Induce Superovulation in Immature Mice

P45
Olavarria J1, Machin A1, Possessky S1, Wilson D1, Fernandez-Metzler C2, King R2, Hillegass J1. 1Lampire Biological Laboratories, Inc., Pipersville, PA, United States, 2PharmaCadence Analytical Services, LLC, Hatfield, PA, United States. Targeted Proteomic Analysis Associated with an In Vitro Zebrafish Developmental Toxicology Assay Using LC-MS/MS

P46
Hansen DK1, Nakamura N1, Juliar B1, McIntyre B2, Foster PMD2, Inselman AL1. 1US Food and Drug Administration, NCTR, Jefferson, AR, United States, 2National Toxicology Program, NIEHS, Research Triangle Park, NC, United States. Preliminary Results from Segment I Fertility Study of Oxybenzone in Rats

P47
Inselman AL1, Nakamura N1, Juliar B1, McIntyre B2, Foster P2, Hansen DK1. 1US Food and Drug Administration, NCTR, Jefferson, AR, United States, 2National Toxicology Program, NIEHS, Research Triangle Park, NC, United States. Preliminary Results: Effects of Oxybenzone Exposure on Pre- and Postnatal Development in Rats

P48
Papineni S2, Hannas BR1, Zablotny CL1, Bell MP1, Marshall VA1, McCoy AT1, Billington R2, Rasoulpour RJ2. 1The Dow Chemical Company, Midland, MI, United States, 2Dow AgroSciences, LLC, Indianapolis, United States. Applying the 3R’s in Regulatory Testing: Use of the Developmental Toxicity Limit Test to Reduce Animal Use in Development of a Novel Agrochemical

P49
Solomon HM, Ziejewski MK, Rendemonti J. GlaxoSmithKline Pharmaceuticals, King of Prussia, PA, United States. Comparison between a Modified Mid-Coronal Sectioning Technique and Wilson’s Technique When Conducting Head Examinations in Fetal Rabbits

P50
Berry M, Sarangarm D, Schmitt C, Gutierrez H, Shrestha S, Savage DD, Bakhireva LN. University of New Mexico, Albuquerque, NM, United States. Feasibility of Confirming Alcohol Consumption from Banked Dry Blood Spot Cards

P51
Euling SY1, Hogan K1, Cooper G1, Cai C1, Blessinger T1, Christensen KY1, Lorber M1, Arzuaga X1, Sheth C2, Sasso A1, Pratt M1, Hotchkiss A3, Lambert JC4. 1NCEA, US Environmental Protection Agency, Washington, DC, United States, 2CDER, US Food and Drug Administration, Silver Spring, MD, United States, 3NCEA, Environmental Protection Agency, Research Triangle Park, NC, United States, 4NCEA, Environmental Protection Agency, Cincinnati, OH, United States. Di-isobutyl Phthalate (DIBP) Hazard Identification

P52
Xu Y1, Liang Y1, Ma L1, Ascher J3, Despres D2, Ovanesov M1, Struble EB1. 1US Food and Drug Administration, CBER, Division of Hematology, Bethesda, MD, United States, 2Nations Institutes of Health Mouse Imaging Facility, Bethesda, MD, United States, 3US Food and Drug Administration, CBER, Division of Veterinary Services, Bethesda, MD, United States. In Vivo and In Vitro Methods for Investigating Thrombosis during Pregnancy

P53
López-Uriarte GA1, Medina Aguado MM1, Torres de la Cruz VM1, Sepúlveda González G2, Villagomez Martínez G2, Martínez Garza LE1. 1Departamento de Genética, Facultad de Medicina, Hospital Universitario, UANL, Monterrey, Nuevo León, Mexico, 2Servicio de Perinatología, Hospital Universitario, UANL, Monterrey, Nuevo León, Mexico. Determination of Potential Biomarkers for Prenatal Diagnosis of Chromosomopathies

P54
ALJOBAIR AM1, ALSALEEM A2. 1King Saud University, College of Dentistry, Riyadh, Saudi Arabia, 2Dental Department, Prince Sultan Medical Military City, Riyadh, Saudi Arabia. Possible Association between Maternal Acetazolamide and Congenital Oligodontia, Ectrodactyly, Syndactyly: A Case Report

P55
Miller BM1, Wells KK1, Lam XT1, Wells CB1, Carney ME1, Herguth CM1, Hood RD2, Bailey MM1. 1Emporia State University, Emporia, KS, United States, 2Ronald D. Hood & Associates, Tuscaloosa, AL, United States. Evaluation of Effects of Exposure to N-Acetyl-L-cysteine on Cyclophosphamide Teratogenesis in CD-1 Mice

P56
Hrubec TC1,2, Melin VE2, Potineni H2. 1E. Via College of Osteopathic Medicine, Virginia Campus, Blacksburg, VA, United States, 2VA-MD Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, United States. Developmental and Reproductive Toxicities of QAC Disinfectants Are Multigenerational

P57
Posobiec LM1, Vanneman M2, Brannen K2, Ziejewski MK1, Dehaas C1, Lewis E2, Solomon H1, Hoberman A2. 1GlaxoSmithKline, King of Prussia, PA, United States, 2Charles River Preclinical Services, Horsham, PA, United States. Building a Successful Shared Science Partnership between Pharmaceutical Companies and Contract Research Organizations (CRO)

P58
Dodd-Butera T1,2, Pritty-Broderick M3, Beaman M1, Clark R3. 1CSU San Bernardino, San Bernardino, CA, United States, 2SDSU Graduate School of Public Health, San Diego, CA, United States, 3California Poison Control System, San Diego Division, San Diego, CA, United States. Carbon Monoxide Exposures and Pregnancy: An Investigation from the California Poison Control System

P59
LaRocca J1,3, Binder A1,2, Michels K1,2. 1Harvard University School of Public Health, Boston, MA, United States, 2Brigham and Women’s Hospital, Boston, MA, United States, 3Harvard University Center for the Environment, Cambridge, MA, United States. First Trimester Phthalate and Phenol Exposure is Associated with miRNA Alterations in the Placenta

P60
Olitan TA1, Wang J1, Wang L1, Arnold M2, Weinbauer G2, Sivaraman L1, McNerney M1. 1Bristol-Myers Squibb, New Brunswick, NJ, United States, 2Covance Laboratories, Inc, Madison, WI, United States. Comparative Analysis of Placental Transfer of a Monoclonal Antibody at the End of Organogenesis in Guinea Pig and Cynomolgus Monkey

P61
Willis ED1, Marko A1, Marin M2, Rasmussen SA2, Bialek SR2, Redfield A1, Dana A1. 1Merck & Co., Inc., North Wales, Pennsylvania, United States, 2Centers for Disease Control and Prevention, Atlanta, GA, United States. Pregnancy Registry for Varicella-Zoster Virus-Containing Vaccines: 17-Year Summary of Pregnancy Outcomes

 

   
7:30 PM–8:30 PM COMMUNICATIONS WORKING GROUP MEETING – Evergreen Ballroom G
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   

 

 

 




Rev. Wednesday, June 4, 2014; at 4:24:17 PM EDT
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