The 2013 Program Committee of the Teratology Society, partnering with the Organization of Teratology Information Specialists (OTIS) and the Neurobehavioral Teratology Society (NBTS), has arranged for an outstanding and expansive scientific program. The program for the Teratology Society Annual Meeting includes three education courses, eight cutting-edge scientific symposia, one workshop, eight lectures, and one roundtable. There are also opportunities for open research communications such as platform talks (five sessions) and poster presentations (two sessions). The session topics address newer concepts in the field and are likely to generate lively interaction.
Separate registration is required for the Education Course Sessions and the Sunrise Mini Course, so please register early!
- Education Course
- Session 1: Principles of Teratology
The morning session of the 2013 Continuous Education Course will focus on basic concepts and research applications. Topics include timeline of important events for embryo-fetal development, direct and indirect developmental toxicity including maternal, placental, and fetal considerations, common pathways and mechanism of action of teratogens, regulatory study designs for detecting developmental toxicants, and detecting signals of concern in the human population.
- Session 2: Advanced Technologies in Prenatal & Postnatal Screening & Diagnosis: From Basic Science to Clinical Applications
The second session for the 2013 Continuous Education Course will discuss the advanced technologies and screening tools for use in the pre-and postnatal diagnosis. The topics include imaging, genetic screening in IVF babies, screening of maternal thyroid function during pregnancy and potential biomarkers for preeclampsia.
- Sunrise Mini Course
Advanced Technologies in Genetics and Genomics: Applications to the Prevention of Birth Defects and the Communication of Risk
Our Tuesday Sunrise Mini Course will address current technologies in genetic testing and applications of technologies and communication of risk.
- Josef Warkany Lecture
Recognizes a scientist who has significantly contributed to the field of teratology. The 2013 Josef Warkany Lecturer is Robert J. Kavlock.
- F. Clarke Fraser New Investigator Award
This award honors F. Clarke Fraser, one of the founding members of the Teratology Society, for his many contributions to the field of developmental toxicology. It is intended that the presentation will serve as a demonstration to pre- and postdoctoral students of the development of an independent career in birth defects research. The 2013 recipient of the F. Clarke Fraser New Investigator Award is Peixin Yan.
- James G. Wilson Publication Award
This annual award is presented in recognition of the best paper accepted or published in the journal Birth Defects Research.
- European Teratology Society and TS Exchange Lecture
The Use of a Second Species in Developmental Toxicity Testing
The European Teratology Society (ETS) and Teratology Society have set up an Exchange Lecture again this year. This lecture will provide an opportunity for interactions and to share perspectives. The ETS perspective will be presented by Georg Schmitt and Susan Makris will represent TS. Come and express your opinions.
- TS/NBTS Joint Lecture
Role of the Placenta in Fetal Brain Development and Functional Outcomes: Developmental Programming & Prenatal Environments
Pat Levitt, University of Southern California
- Special Lecture
- Robert L. Brent Lecture
This lecture is presented to facilitate the discussion of new and old teratogens during the annual meeting. The 2013 Robert L. Brent Lecturer is Joe Leigh Simpson.
- Special Lecture
- Adverse Outcome Pathways (AOPs) in Predictive Toxicology Symposium
High-throughput screening is providing vast data that can be used to inform regulatory toxicity testing and risk assessment. Translating these mechanistic data into a plausible toxicity prediction requires a scientifically-based framework to conceptualize the relevant linkages between molecular initiating events (MIE) and adverse outcome(s), such as adverse outcome pathways (AOPs). AOPs ideally describe the sequential flow of information across different scales of biological organization and complexity leading to an in vivo outcome of regulatory value. This symposium will highlight the many purposes of AOP methodology for ‘predictive toxicology’ and integrating HTS data and other in vitro data for developmental processes and toxicities. Individual topics will address a range of current issues including: the main information blocks needed to build AOPs; compilation of MIEs and effects into AOP libraries for developing chemical categories that can inform QSAR profilers; the use of AOPs to integrate data from in vitro profiling studies into systems models for dose predictivity; and the identification of research needs to fill data gaps in the cascade of events from MIE to adverse outcome.
- TS/OTIS Joint ILSI-HESI Symposium
Communication of Risk for Medication Use in Pregnancy and Lactation
The anticipated Pregnancy Labeling and Lactation Labeling Rule will change the structure of the current Pregnancy and Nursing Mothers sections of the US label. The proposed labeling changes will reformat and present the clinically relevant available human and animal data. This symposium will examine the sources and types of data needed to write informed labeling to convey potential risks for pregnant, breastfeeding, and reproductively active women and more broadly, how to best communicate risk when the data indicate effects of the drugs (or the underlying disease) on fertility, fetal development and lactation.
- TS/NBTS Joint Symposium
Prenatal Origins of Neuropsychiatric Disorders Symposium
Learn the latest theories and evidence on the prenatal origins of neuropsychiatric disorders. Speakers will summarize the growing body of experimental and human epidemiological evidence that prenatal infection or maternal immune activation in the absence of viral or bacterial agents cause fetal brain inflammatory reactions leading to neurotransmitter changes.
- Wiley-Blackwell Symposium
Application of Imaging Technologies in Birth Defects Research and Clinical Practice
Imaging technologies have become of paramount importance in all facets of developmental biology research as well as in clinical medicine. Significant advances have been made in all areas of imaging technologies. This symposium includes presentations on a variety of cutting edge imaging modalities used in research from the cellular to the whole animal level. In addition, the application and use of imaging in clinical research and medical practice for the assessment of pre- and postnatal dysmorphologies will be addressed.
- TS/NBTS Joint Symposium
Honoring the Legacy of Dr. Patricia M. Rodier
Patricia Martin Rodier, PhD passed away in May, 2012. Dr. Rodier was a scientist with an international reputation, who trained and collaborated with scientists from around the world. Her doctoral degree was in experimental psychology and her postdoctoral fellowship in embryology with Jan Langman. Her interest in how altering brain development affected behavior lead her to become an embryologist, teratologist, and neuroanatomist. She was one of the founding members, and second president, of the Neurobehavioral Teratology Society. Dr. Rodier's research was some of the seminal work detailing how timing of exposures to a variety of different agents, such as heavy metals, anesthetics, alcohol, and hormones altered brain development and resulting in altered behavior in the offspring. Using what she knew as an neuroembryologist and behavioral teratologist, she developed the hypothesis and demonstrated that autism's origins can be caused by insults during early embryonic development. This symposium brings together former students and other scientists who have been profoundly affected by Dr. Rodier's teachings and research to discuss their research and her legacy.
- TS/OTIS Joint Symposium
Cancer and Pregnancy: Considerations regarding the Use of Chemotherapy
Cancer during pregnancy affects approximately 17 to 100 in 100,000 pregnant women. Some cancers may require immediate treatment with systemic therapies, which are known developmental toxicants. Most literature on pregnancy outcomes in women treated with chemotherapy for cancer report only a small number of cases, i.e., case reports or case series. However, pregnancy registries and clinical trials may provide a more consistent evaluation of these pregnancy outcomes, as well as long term follow up of the offspring gestationally-exposed to chemotherapy for cancer. Recent advances in fertility preservation may also ensure that reproductive age patients diagnosed with cancer have optimal chances of reproductive success post-treatment for cancer. The goal of this symposium is to explore the current diagnostic and systemic treatment regimens used to treat breast cancer in pregnant patients, discuss a current registry effort to assess the pregnancy outcomes in pregnant women with cancer, and briefly review the National Toxicology Program’s recent evaluation of developmental effects and pregnancy outcomes associated with treatment with cancer chemotherapy during pregnancy. Finally, the symposium will conclude with a presentation on the latest methods of fertility preservation in patients with cancer.
- March of Dimes Symposium
Advances in the Genomic Sciences towards Public Understanding and Predicting Developmental Defects
Scientific tools are being developed at an incredibly rapid rate, including ones that we had not envisioned possible just a short time ago. Each of the individual disciplines that form the foundation of the Society has access today to their own sets of cutting-edge approaches. The challenge for Society members is to collaborate in a transdisciplinary manner and apply these approaches systematically to address the common goal of understanding the causes and mechanisms of birth defects, and, thereby, find solutions to prevent them. This symposium will highlight how new and exciting technologies of genomics, epigenomics, proteomics, transcriptomics, and metabolomics can be applied to predict, identify, and further our understanding of the underlying mechanisms of developmentally-mediated disorders from the bench to the clinical setting.
- Public Affairs Committee Symposium
Diabetes and Pregnancy
The rate of diabetes is increasing by approximately 10% per year, and in parallel there is an increase in the number of women with diabetes type 1 or type 2 that become pregnant. About 1.85 million women of reproductive age (18-44 yrs) have diabetes, mainly insulin resistant type 2 diabetes, which accounts for most cases identified during this life stage. Pregestational diabetes (PGD) occurs in about 0.4-0.5% of pregnant women who have either insulin deficient type 1 or type 2 diabetes. In addition, approximately 2.5-4% of women in the US develop gestational diabetes during pregnancy, due to an increased resistance to insulin. Women with gestational diabetes (GD) have an increased risk of recurrence with subsequent pregnancies and an increased risk of developing type 2 diabetes with age. All forms of diabetes might have a significant effect on the course of pregnancy, including specific effects on fetal growth, rate of congenital anomalies and, in addition, on the well being, growth and development later in life. It is the purpose of this symposium to address these issues and describe treatments or interventions to prevent these complications.
- TS/OTIS Joint Pregnancy Registry Workshop
Speakers and abstract presenters will review the designs and lessons from ongoing multi-drug pregnancy registries for antiepileptic, atypical antipsychotic, antiretroviral, transplant, and fibromyalgia medications. Issues of models, challenges, collaborative efforts, prioritizing classes, and postmarketing trends will be explored to provide helpful lessons for considering future multi-drug and multi-site studies.
The Teratology Society is pleased to offer a venue for companies who are active in the field of teratology to meet with the Annual Meeting attendees. Exhibitors will be on hand to discuss their products and how they can help you achieve your research and professional goals. Plan to visit the exhibitors and learn more about their products and services during the Welcome Reception and both poster sessions.
- Welcome Reception
Don’t miss the first social event of the meeting. This is an excellent opportunity to catch up with old friends and make new ones.
- TS/NBTS/OTIS Joint Poster Session 1 and Poster Session 2
Attendees of all three Societies present abstracts during the first poster session of the meeting and the attendees of Teratology Society present abstracts during the second poster session. The poster sessions provide a relaxed atmosphere to interact with both trainees and established scientist while viewing the latest research in the field of teratology.
- Teratology Society 32nd Annual Volleyball Game
Whether you want to join the game or cheer on your colleagues, don’t miss this landmark event. For the past 31 years the attendees of the Teratology Society meeting have gathered on a local volleyball court and enjoyed a friendly, albeit competitive, game of volleyball.
- Annual Banquet
The scientific sessions have ended, friendships and professional contacts have been made, and now it is time to relax. Plan to attend the last event of the meeting and join your colleagues in honoring those selected to receive awards. Watch the Society’s President pass on the gavel, enjoy great food, and dance the night away.
Each Teratology Society attendee receives a ticket to the banquet with their meeting registration. The tickets are non-transferable. Additional tickets can be purchased at the registration desk. Badges and banquet tickets are required to attend the banquet.
As you can see, the 2013 program represents the great strengths of our multidisciplinary society and presents something for everyone. We invite you to experience the excitement in Tucson!