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(Updated 11-APR-2006)

Saturday, June 24	Sunday, June 25	Monday, June 26	Tuesday, June 27	Wednesday, June 28	Thursday, June 29
Education Course: Vertebrate Embryology	Education Course continued	WARKANY LECTURE George P. Daston	SUNRISE MINI-COURSE Developmental Pharmaco-kinetics	PLATFORM SESSION III Mechanisms II	PUBLIC AFFAIRS COMMITTEE PLATFORM SESSION Regulatory Science
	TS/NBTS JOINT SYMPOSIUM Early Exposures: Childhood Behavior Disorders	Wilson Publication Award Presentation and Address Diana M. Juriloff	MARCH OF DIMES SYMPOSIUM New Insights in Myogenesis: Implications for Muscle Development, Birth Defects, and Regeneration	TS/NBTS JOINT SYMPOSIUM Recent Advances in Research on the Safety of Thimerosal in Vaccines	PLATFORM SESSION IV Mechanisms III
	INTERNATIONALLY HARMONIZED UPDATES TO “TERMINOLOGY OF DEVELOPMENTAL ABNORMALITIES, VERSION 1”	Student Platform Session	TS/NBTS Poster Session II and Exhibits Open	WARKANY TEA	THYROID HORMONE AND BRAIN DEVELOPMENT: BASIC BIOLOGY, TOXICOLOGY, AND PUBLIC HEALTH SYMPOSIUM
	Welcoming Reception and Exhibits Open	F. Clarke Fraser Award Christina D. Chambers	TS/OTIS JOINT SYMPOSIUM Emerging Infections: Mechanisms of Inflammation During Pregnancy Diseases	RARE DISEASES SYMPOSIUM Chemically Induced Congenital Anomalies: Is Oxidative Stress a Common Pathway?	COUNCIL II MEETING
		POSTERS AND EXHIBITS OPEN	PLATFORM SESSION I Epidemiology - Clinical Teratology	MARTA/MTA PEDIATRIC SYMPOSIUM Pediatric Safety Evaluation: Regulatory, Nonclinical, and Clinical Experience
		ROBERT L. BRENT LECTURE John Rogers	TS/OTIS JOINT SYMPOSIUM Emerging Infections: Viruses Beyond Rubella	RARE DISEASES ROUNDTABLE
		TS/NBTS JOINT SYMPOSIUM Endocrine Disruption: From Animal to Human Studies	PLATFORM SESSION II Mechanisms I	WILEY LISS SYMPOSIUM MicroRNAs in Vertebrate Development
		TS/OTIS JOINT PLATFORM SESSION		BUSINESS MEETING AND REPORTS FROM BIRTH DEFECTS RESEARCH EDITORS
		TS/OTIS JOINT ROUNDTABLE Communicating Teratogenic Risk Information: Case Studies inand Perception		RECEPTION AND BANQUET
		NATIONAL CHILDREN’S STUDY: Planning and Implementation
		TS/NBTS/OTIS JOINT POSTER SESSION I
		MARTA/MTA STUDENT CAREER EVENT

Saturday, June 24	top
9:00 AM - 12:00 NOON	COUNCIL 1A MEETING-Executive Board Room
11:30 AM - 5:00 PM	REGISTRATION—Grand Ballroom Foyer
1:00 PM - 4:50 PM	EDUCATION COURSE PART I (separate registration required)—Salon B
Vertebrate Embryology Organized by the Education Committee, Gloria Jahnke, Chairperson Coursebooks provided by Charles River Laboratory Preclinical Services-CTBR Breaks co-supported in part by Covance, DuPont Haskell Laboratory for Health and Environmental Science, and Gene Logic Laboratories Welcome Melissa S. Tassinari, President, Teratology Society Introduction Speaker: Gloria Jahnke, Sciences International, Inc. Narsingh Agnish Fellowship Speaker: Narsingh Agnish Comparative Cleavage & Gastrulation Speaker: Gary C. Schoenwolf, University of Utah Brain-Neural Tube Development Speaker: Richard H. Finnell, Institute of Biosciences and Technology Craniofacial Development Speaker: Lori Kotch, John Hopkins University School of Medicine Skeletal Development (Including Limb) Speaker: Michael D. Collins, UCLA School of Public Health
6:30 PM - 9:00 PM	COUNCIL 1B MEETING (Committee Reports)—Executive Board Room
Sunday, June 25 top
7:30 AM - 8:00 AM	Education Course Coffee and Continental Breakfast—Grand Ballroom Foyer
8:00 AM - 7:00 PM	REGISTRATION—Grand Ballroom Foyer
8:00 AM - 11:25 AM	EDUCATION COURSE PART II: (CONTINUED FROM SATURDAY)—Salon B
Vertebrate Embryology Heart Development Speaker: John DeSesso, Mitretek Systems Urogenital Development Speaker: Kok-Wah Hew, Emisphere Technologies, Inc. Xenopus Model Speaker: Chris Wylie, Cincinnati Children’s Hospital Medical Center Zebra Fish Model Speaker: Kim Brannen, Bristol-Myers Squibb
2:00 PM - 5:00 PM	TS/NBTS JOINT SYMPOSIUM—Salon B
Early Exposures: Childhood Behavior Disorders Chairs: Cynthia F. Bearer, Case Western Reserve University and Jane Adams, University of Massachusetts Autism: Parsing Heterogeneity of Causes and Features Speaker: Martha Herbert, Massachusetts General Hospital Biomarkers of Prenatal Alcohol Exposure Correlate with Poor Developmental Outcomes Speaker: Cynthia F. Bearer, Case Western Reserve University Low Level Lead Exposure and the Risk of Delinquency: It’s Not Just Cognition that’s Affected Speaker: Herbert L. Needleman, University of Pittsburgh School of Medicine Neuropsychological Deficits in Neonatal Dietary Manganese Exposure Speaker: Francis M. Crinella, University of California, Irvine
2:00 PM - 5:00 PM	INTERNATIONALLY HARMONIZED UPDATES TO “TERMINOLOGY OF DEVELOPMENTAL ABNORMALITIES, VERSION 1” Symposium—Salon A
Chairs: Susan Makris U.S. Environmental Protection Agency and Howard Solomon, GlaxoSmithKline Introduction, Background, and Current Status of Terminology Update Project Speaker: Susan Makris, U.S. Environmental Protection Agency Terminology Revision—A European Perspective Speaker: Jochen Buschmann, Fraunhofer-Institute for Toxicology and Experimental Medicine A Japanese Perspective on Terminology Revision Speaker: Kohei Shiota, Kyoto University Graduate School of Medicine An Introduction to: “Terminology of Developmental Abnormalities, Version 2” Speaker: Howard Solomon, GlaxoSmithKline
5:00 PM - 6:15 PM	WELCOMING RECEPTION AND EXHIBITS OPEN Co-sponsored by Gene Logic Laboratories and MPI Research —Kiva Ballroom
Monday, June 26 top
7:00 AM - 8:00 AM	2007 Program Committee Meeting—Executive Boardroom
7:00 AM - 8:00 AM	Student Affairs Committee Meeting—Sabino
7:30 AM - 8:00 AM	Coffee and continental Breakfast—Kiva Ballroom
8:00 AM - 5:00 PM	REGISTRATION—Grand Ballroom Foyer
8:00 AM - 8:10 AM	PRESIDENT'S WELCOME—Salon B Melissa S. Tassinari
8:10 AM - 9:00 AM	THE JOSEF WARKANY LECTURE—Salon B Genomics and Assessment of Developmental Risks Speaker: George P. Daston, Procter & Gamble Company
9:00 AM - 9:30 AM	JAMES G. WILSON PUBLICATION AWARD PRESENTATION AND ADDRESS—Salon B Investigations of the Genomic Region that Contains the clf1 Mutation, a Causal Gene in Multifactorial Cleft Lip and Palate in Mice Diana M. Juriloff, University of British Columbia
9:30 AM - 9:45 AM	Coffee Break—Grand Ballroom Foyer
9:45 AM - 11:30 AM	STUDENT PLATFORM SESSION —Salon B
Chair: Wafa A. Harrouk, U.S. Food and Drug Administration Safety of Leukotriene Receptor Antagonists in Pregnancy Bakhireva LN, Jones KL, Chambers CD.OTIS Collaborative Research Group. University of California, San Diego, La Jolla, CA, United States. Vitamin K Homeostasis May be Required for Yolk Sac Angiogenesis Weston AD1, Navetta K2, Brown NA3, Ozolins TR1. 1Investigative and Developmental Toxicology, Pfizer Global Research and Development, Groton, CT, United States, 2Molecular Investigative Toxicology, Pfizer Global Research and Development, Groton, CT, United States, 3Division of Basic Medical Sciences, St. George’s University of London, London, United Kingdom. Molecular Characterization of Alcohol-Related Birth Defects in Two Closely Related Lineages of C57BL/6 Mice (B6N, B6J) Green ML, Singh AV, Zhang Y, Knudsen TB. University of Louisville, Louisville, KY, United States. Altered Gene Expression in Both Ectoderm and Mesoderm are Associated with a Murine Strain Difference in Retinoic Acid-Induced Forelimb Ectrodactyly in Retinoic Acid-Induced Forelimb Ectrodactyly Shimizu H1, Lee GS2, Collins MD1,2. 1UCLA School of Public Health, Los Angeles, CA, United States, 2UCLA Molecular Toxicology Interdepartmental Program, Los Angeles, CA, United States. Mechanism Underlying Arsenic-Induced Neural Tube Defects in a Mouse Model Hill DS, Wlodarczyk BJ, Finnell RH. CEGM, Institute of Biosciences and Technology, Texas A&M University SHSC, Houston, TX, United States. Combining Microarrays with Comparative Genomics to Elucidate Gene Regulatory Networks for Normal and Perturbed Forebrain Development Gohlke JM, Parham FM, Portier CJ. NIEHS, Chapel Hill, NC, United States. Immunological and Pathological Effects of Listeria monocytogenes Infection in Pregnant Guinea Pigs Irvin EA1, Williams D1, Voss KA2, Smith MA1. 1University of Georgia, Athens, GA, United States, 2U.S. Department of Agriculture–ARS, Athens, GA, United States
11:30 AM - 12:00 PM	F. CLARKE FRASER AWARD -- Salon B Christina D. Chambers, University of California—San Diego, San Diego, CA
12:00 PM - 1:00 PM	Past Presidents' Lunch (By invitation only) - Executive Boardroom
12:00 PM - 1:00 PM	Lunch on Own
12:30 PM - 7:30 PM	POSTERS AND EXHIBITS OPEN—Kiva Ballroom (Attended 6:00 PM-7:30 PM)
1:00 PM - 3:30 PM	TS/NBTS JOINT SYMPOSIUM—Salon A
Endocrine Disruption: From Animal to Human Studies Chairs: Elaine Z. Francis, U.S. Environmental Protection Agency and Mari Golub, University of California - Davis Introduction The “Phthalate Syndrome” In Rodents: Have We Identified the Human Analog? Speaker: Shanna H. Swan, University of Rochester PCBs and Auditory Function: From Animal Models to Human Infants Speaker: Susan Schantz, University of Illinois, Urbana Human and Animal Studies of Pubertal Development Following Perinatal Exposure to PBBs Speaker: Michele Marcus, Emory University Fetal Exposure to Dioxin Disrupts Progesterone Responsiveness in the Adult Murine Uterus: Implications for the Development of Endometriosis in Humans Speaker: Kevin G. Osteen, Vanderbilt University School of Medicine Genetic and Environmental Risk Factors for Hypospadias Speaker: Jeanne Manson, The Children’s Hospital of Philadelphia Panel Discussion: Problems and Solutions in Moving from Animal to Human Studies Discussion Leader: Jeanne Manson, The Children’s Hospital of Philadelphia
1:00 PM - 2:00 PM	ROBERT L. BRENT LECTURE - Teratogen Update—Salon B Chair and Commentator: Robert L. Brent, DuPont Hospital for Children Of Mice, Men, Monkeys, and Metabolism: An Update on the Developmental Toxicity of Methanol (Abstract S13A) Speaker: John Rogers, U.S. Environmental Protection Agency
2:00 PM - 3:30 PM	TS/OTIS JOINT PLATFORM SESSION—Salon B
Chairs: Lewis B. Holmes, Massachusetts General Hospital for Children and Kenneth Lyons Jones, University of California—San Diego Increased Risk for Non-Syndromic Cleft Palate Among Infants Exposed to Lamotrigine During Pregnancy Holmes LB, Wyszynski DF, Baldwin EJ, Habecker E, Glassman LH, Smith CR. North American AED Pregnancy Registry, MassGeneral Hospital for Children, Boston, MA, United States. Outcomes of Human Pregnancies with Levetiracetam Exposure ten Berg K1, Van Oppen ACC1, Van Donselaar CA1, Wentges-Van Holthe JM2, Koppe WM3, Tamminga P4, Lindhout D1. 1University Medical Center Utrecht, Utrecht, Utr, Netherlands, 2National Institute for Public Health and the Environment, Bilthoven, Utr, Netherlands, 3Bethesda Hospital, Hoogeveen, Dr, Netherlands, 4Academic Medical Center, Amsterdam, NH, Netherlands. Seasonal Conceptions in Neural Tube Defects, Schizophrenia and Hemispheric Laterality: Evidence Implicating Differential Embryonic Survival Marzullo G. Per Aspera Research Foundation, New York, NY, United States. Risk of Congenital Malformations in Pregnant Users of NSAIDs Ofori B1,2, Oraichi D2, Berard A1,2. 1Faculty of Pharmacy, University of Montreal, Montreal, QC, Canada, 2Sainte Justine Hospital, Montreal, QC, Canada. Failure of Pregnancy Prevention for Category X Medications: the Example of Leflunomide Tassinari E1, Johnson D2, Chambers CD2, Jones KL2, OTIS Collaborative Research Group2. 1George Washington University, Washington DC, United States, 2University of California San Diego, La Jolla, CA, United States. Neurodevelopmental Outcome in Children of Women Treated with Anticonvulsant Monotherapy Mattson SN1, Chambers CD2, Vander Velde JJ1, Kao KK2, Jones KL2. 1Center for Behavioral Teratology, San Diego State University, San Diego, CA, United States, 2Department of Pediatrics, Division of Dysmorphology and Teratology, University of California, San Diego, La Jolla, CA, United States.
3:30 PM - 3:45 PM	Break
3:45 PM - 5:45 PM	TS/OTIS JOINT ROUNDTABLE—Catalina Ballroom
Communicating Teratogenic Risk Information: Case Studies in Teratogenic Risk Communication and Perception Chairs: Janine E. Polifka, University of Washington and Christina D. Chambers, University of California, San Diego Risk Communication: Importance of Context and Effect for Medical Decisions Speaker: Paul Slovic, Decision Research Institute Risk Communication in the Face of Uncertainty and New Findings Speaker: Alice Hughes, Center for Drug Evaluation and Research, U.S. Food and Drug Administration Cultural Differences in Risk Perception and Assessment Speaker: Lee Ann Kaskutas, University of California, Berkeley Communication of Fluorochemical Research to Production Workers Speaker: Geary Olsen, 3M Corporate Occupational Medicine Panel Discussion: Risk Communication Challenges– Implications for Teratogen Information
3:45 PM - 5:45 PM	NATIONAL CHILDREN’S STUDY: PLANNING AND IMPLEMENTATION —Salon B
Chair: Carole A. Kimmel, Consultant, National Children’s Study, NICHD/NIH Introduction Speaker: Carole A. Kimmel, Consultant, National Children’s Study, NICHD/NIH Update on the Study Protocol Speaker: Ruth A. Brenner, National Children’s Study, NICHD/NIH Coordination of the National Children’s Study Speaker: Carla Maffeo, Westat Corporation Community Engagement and Recruitment in a Vanguard Center Speaker: Edward B. Clark, University of Utah Health Sciences Center The North Carolina Herald Pilot Study Speaker: Pauline Mendola, National Health and Environmental Effects Research Laboratory, ORD/U.S. EPA
5:30 PM - 7:30 PM	TS/NBTS/OTIS JOINT POSTER SESSION I and EXHIBITS OPEN—Kiva Ballroom Co-sponsored by Gene Logic Laboratories and GlaxoSmithKline (Posters attended from 6:00 PM - 7:30 PM) Teratology Society Posters P1–P27 P1–P17: Clinical Teratology and Epidemilogy P18–P21: Public Policy P22–P27: Mechanisms–Animal Model NBTS Posters NBTS24–NBTS33 OTIS Posters OTIS-P1–OTIS-P2
7:30 PM - 10:30 PM	MARTA/MTA STUDENT CAREER EVENT—Bill’s Grill
Tuesday, June 27 top
6:30 AM - 7:00 AM	MINI COURSE BREAKFAST-Salon B
7:00 AM - 8:30 AM	BDRA Editorial Board Meeting—Executive Boardroom
7:00 AM - 8:30 AM	BDRB Editorial Board Meeting—Sabino
7:00 AM - 5:00 PM	REGISTRATION—Grand Ballroom Foyer
7:00 AM - 8:30 AM	SUNRISE MINI COURSE (Separate registration Required) —Salon B
Developmental Pharmacokinetics Organized by the Education Committee: Gloria Jahnke, Chairperson Coursebooks provided by Charles River Laboratory Preclinical Services–CTBR Prenatal Pharmacokinetics (Maternal & Fetal) Speaker: Edward W. Carney, The Dow Chemical Company Postnatal Pharmacokinetics (Postnatal Through Juvenile) Speaker: Hugh Barton, U.S. Environmental Protection Agency
8:00 AM - 8:30 AM	COFFEE AND CONTINENTAL BREAKFAST-Kiva Ballroom
8:00 AM - 1:30 PM	POSTERS AND EXHIBITS OPEN-Kiva Ballroom (Attended 11:45 AM–1:30 PM)
8:30 AM - 11:30 AM	MARCH OF DIMES SYMPOSIUM-Salon B
New Insights in Myogenesis: Implications for Muscle Development, Birth Defects, and Regeneration Chair: Tyra M. Leazer, Procter & Gamble Company Sponsored by March of Dimes Introduction Introductions to Muscle Dystrophies: Insights from the Clinic Speaker: Jan K. Blancato, Georgetown University Medical Center Asymmetry in Myogenesis Speaker: Charles P. Ordahl, University of California—San Francisco BREAK Myogenesis Development and Molecular Control: Role of the Rho Family of Small GTPases Speaker: Mingyao Liu, Texas A&M University Genetics of Muscular Dystrophy and Disease: Impact and Implications of Polymorphisms in Animals and Humans Speaker: Eric Hoffman, Children’s Research Institute
11:30 AM - 1:30 PM	TS/NBTS POSTER JOINT SESSION II AND EXHIBITS OPEN-Kiva Ballroom Co-sponsored by Gene Logic Laboratories and GlaxoSmithKline (Posters attended 11:45 - 1:30 PM) Teratology Society Posters P28–P61: P28–P38: Hazard/Risk Evaluation P39–P53: Mechanisms P54–P61: Methods NBTS Posters NBTS34–NBTS38
1:30 PM - 3:15 PM	PLATFORM SESSION I-SALON B
Epidemiology—Clinical Teratology Chair: Suzan L. Carmichael, California Birth Defects Monitoring Program Childhood Cancer and Pesticides - A Case-Control Study of Possible Gene-Environment Interactions Soldin OP1,2, Loffredo CA1, Shields PG1, Barr D3, Luban N4, Shad A1, Nelson D5. 1Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, United States, 2Department of Medicine and Center for Sex Differences, Washington, DC, United States, 3Centers for Disease Control and Prevention, Atlanta, GA, United States, 4Children’s National Medical Center, (CNMC), George Washington University, Washington, DC, United States, 5Department of Pediatrics, Georgetown University Medical Center, Washington, DC, United States. Child Neurodevelopment Following Exposure to Venlafaxine In Utero, Unexposed Siblings as Comparison Groups: Preliminary Results Nulman I1,2, Knittel-Keren D1,2, Valo S1,2, Sussman R1,2, BarrerA M1,2, Koren G1,2. 1University of Toronto, Toronto, ON, Canada, 2Hospital for Sick Children, Toronto, ON, Canada. Evaluation of Clinical Presentation in Neonates Exposed to Antidepressants in Late Pregnancy Boucher N1,2, Bairam A1,3, Beaulac-Baillargeon L1,2. 1Perinatalogy Research Unit, Laval University affiliated Hospitals (CHUQ), Saint-Francois d’Assise Hospital, Quebec, QC, Canada, 2Faculty of Pharmacy, Laval University, Quebec, QC, Canada, 3Faculty of Medicine, Laval University, Quebec, QC, Canada. Pregnancy Outcome After In-Utero Exposure to Valproic Acid: A Prospective Controlled Cohort Study Diav-Citrin O1, Shechtman S1, Cantrell D2, Bar-Oz B3,2, Arnon J1, Ornoy A1,2. 1The Israeli Teratogen Information Service, Israel Ministry of Health, Jerusalem, Israel, 2The Hebrew University Hadassah Medical school, Jerusalem, Israel, 3The Department of Neonataology, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel. Long Delay Eyeblink Conditioning in Autism Arndt TL1, Chadman KK2, Watson DJ2, Tsang V1, Rodier PM1, Stanton ME2. 1University of Rochester School of Medicine and Dentistry, Rochester, NY, United States, 2University of Delaware, Newark, DE, United States. Maternal Thyroid Disease as a Possible Risk Factor for Craniosynostosis, National Birth Defects Prevention Study, 1997-2002 Rasmussen SA1, Yazdy M1, Honein M1, Carmichael SL2, Canfield M3. 1Centers for Disease Control and Prevention, Atlanta, GA, United States, 2California Birth Defects Monitoring Program, Berkeley, CA, United States, 3Texas Center for Birth Defects Research and Prevention, Austin, TX, United States. Maternal Stressors and Risks of Selected Birth Defects Carmichael SL1, Shaw GM1, Yang W1, Abrams B2. 1March of Dimes/California Birth Defects Monitoring Program, Berkeley, CA, United States, 2University of California, Berkeley, CA, United States. Birth Prevalence Rate of Major Malformations: Establishing Prevalence Rate of Major Malformations after In-Uterine Exposure: A Challenge for Pregnancy Registries Harel EH, Holmes LB. MassGeneral Hospital for Children, Boston, MA, United States.
1:45 PM - 3:15 PM	TS/OTIS JOINT SYMPOSIUM-Catalina Ballroom
Emerging Infections: Mechanisms of Inflammation During Pregnancy Chairs: Mary Alice Smith, University of Georgia and Dee Quinn, University of Arizona Molecular Mechanisms of Oral Infection Mediated Perinatal Complications Speaker: Steven Offenbacher, University of North Carolina Immunopathogenesis of Malaria during Pregnancy Speaker: Julie Moore, University of Georgia Listeria-Induced Stillbirths:  Impact of Mechanisms of Infection on Risk Assessment Speaker: Mary Alice Smith, University of Georgia
3:15 PM - 3:30 PM	BREAK
3:30 PM - 6:30 PM	TS/OTIS JOINT SYMPOSIUM
Emerging Infections: Viruses Beyond Rubella Chairs: Sonja Rasmussen, Centers for Disease Control and Prevention and Dee Quinn, University of Arizona Introduction Speaker: Sonja Ramassen, Centers for Disease Control & Prevention Is West Nile Virus a Teratogen? Speaker: Dawn M. Wesson, Tulane Health Sciences Center Lymphocytic Choriomeningitis Virus (LCMV): Emerging Fetal Teratogen Speaker: Marilyn Baird Mets, Northwestern University Risks and Benefits of Immunizing Pregnant Women: The Risk of Doing Nothing Speaker: Robert L. Brent, Alfred I. duPont Hospital for Children Challenges to the Study, Prophylaxis and Treatment of Pregnant Women for Emerging Infection Speaker: Denise Jamieson, Division of Reproductive Health, Center for Disease Control and Prevention Panel Discussion
3:30 PM - 6:15 PM	PLATFORM SESSION II-Salon B
Mechanisms I Chairs: Louise M. Winn, Queen’s University and E. Sidney Hunter, III, U.S. Environmental Protection Acency Overexpression of c-Ha-ras Protects Against All-trans Retinoic Acid Induced Malformations Marshall EK, Albert JR, Collins MD. University of California Los Angeles, Los Angeles, CA, United States. Comparative Pathogenesis of Cadmium- and/or All-trans Retinoic Acid- Induced Postaxial Forelimb Ectrodactyly in the C57BL/6 Mouse Liao X, Shimizu H, Lee G, Collins MD. University of California, Los Angeles, Los Angeles, CA, United States. Abnormal Yolk Sac Vasculature and Decreased Nitric Oxide in Copper Deficient Mouse Embryos Yang SJ, Lanoue L, Keen CL, Rucker RB, Uriu-Adams JY. University of California, Davis, Davis, CA, United States. Minimal Role for Reactive Oxygen Species in Dichloroacetic Acid-Induced Dysmorphology in Mouse Whole Embryo Culture Hunter, III ES, Rogers EH, Blanton MR. US EPA, RTD, NHEERL, ORD, Research Triangle Park, NC, United States. Benzene Alters Embryonic Pim-1 Signalling and Induces Oxidative Stress in CD-1 Mice Wan J, Winn LM. Queen’s University, Kingston, ON, Canada. The Ontogeny of Circulating Thyroid Hormone Levels in Sprague-Dawley Rats Beck MJ, Fillutzy H, Godsey J, Nemec MD, Stump DG, Holson JF. WIL Research Laboratories, LLC, Ashland, OH, United States. The Effects of Methimazole on Circulating Thyroid Hormone Levels in Sprague-Dawley Rats Beck MJ, Donahue DA, Varsho BJ, Nemec MD, Stump DG, Holson JF. WIL Research Laboratories, LLC, Ashland, OH, United States. Lack of Association Between Cardiovascular Malformations and Treatment with Selective Estrogen Receptor Modulators (SERMs) in Rats and Rabbits Henck JW, Reddy VR, Hilbish KG, Breslin WJ. Eli Lilly and Company, Greenfield, IN, United States. Artesunate: Developmental Toxicity in Monkeys Clark RL1, Kumemura M2, Makori N3, Nakata Y4, Bernard F5, Harrell A5, White TEK1, Arima A2. 1GlaxoSmithKline, King of Prussia, PA, United States, 2SNBL, Kagoshima, Japan, 3SNBL-USA, Everett, WA, United States, 4GlaxoSmithKline, Shibuya-ku, Tokyo, Japan, 5GlaxoSmithKline, Ware, Hertfordshire, United Kingdom. Mitochondrial Involvement of Artesunate Toxicity in Rat Embryonic Erythroblasts Laffan SB1, James AC1, Maleeff BE1, Pagana JM2, Bushdid PB1, Clark RL1, White TEK1. 1GlaxoSmithKline, Safety Assessment, King of Prussia, PA, United States, 2Drexel University, Philadelphia, PA, United States. Dinocap Induced Cleft Palate and Otoconia Agenesis Due to a Single Isomer Tornesi B1, Marshall V1, Carney EW, Billington R2. 1The Dow Chemical Company, Midland, MI, United States, 2Dow AgroSciences, Milton, United Kingdom.
Wednesday, June 28 top
7:00 AM - 8:30 AM	Public Affairs Committee Meeting—Sabino
7:00 AM - 8:30 AM	Publications Committee Meeting—Executive Boardroom
8:00 AM - 5:00 PM	Coffee and Continental Breakfast—Grand Ballroom Foyer
8:00 AM - 5:00 PM	REGISTRATION--Grand Ballroom Foyer
8:00 AM - 9:30 AM	PLATFORM SESSION III-Salon B
Mechanisims II Chairs: Claudia Kappen, University of Nebraska Medical Center and Richard H. Finnell, Institute of Biosciences and Technology Early Embryonic Development in Reduced Folate Carrier (RFC1) Knockout Mice is Characterized by Neural Tube Defects, Absence of Erythropoiesis, and Failure of Chorioallantoic Fusion Gelineau-Van Waes J1, Heller S1, Maddox J1, Eedy J1, Askew J1, Bauer L1, Aleman F1, Finnell RH1,2. 1University of Nebraska Medical Center, Omaha, NE, United States, 2Institute of Biosciences and Technology, Houston, TX, United States. Folic Acid Prevents Conotruncal Malformations in Folbp1 Knockout Mice: Role of Folate in Cardiac Neural Crest Cell Survival and Migration Gelineau-Van Waes J1, Aleman F1, Maddox J1, Bauer L1, Tang L2, Rosenquist T1, Finnell RH2,1. 1University of Nebraska Medical Center, Omaha, NE, United States, 2Institute of Biosciences and Technology, Houston, TX, United States. Maternal Diabetes and Cardiac Malformations: The Role of Pax3, p53-Dependent Apoptosis, and Cardiac Neural Crest Migration Morgan SC1, Relaix F2, Buckingham M2, Sandell L3, Tilghman S4, Loeken MR1. 1Joslin Diabetes Center, Boston, MA, United States, 2Pasteur Institute, Paris, France, 3Stowers-Institute, Kansas City, MO, United States, 4Princeton University, Princeton, NJ, United States. Altered Gene Expression Profiles in Embryos Exposed to Maternal Diabetes Pavlinkova G, Kruger C, Salbaum JM, Kappen C. University of Nebraska Medical Center, Omaha, NE, United States. Orofacial Clefts Induced by Diabetes Are Not Affected by Maternal Immune Stimulation Toops KA1, Hrubec TC1,2, Hollanay SD1. 1VA-MD Regional College of Veterinary Medicine, Blacksburg, VA, United States, 2E. Via Virginia College of Osteopathic Medicine, Blacksburg, VA, United States. Impact of Maternal Diets and Early Environmental Exposure on Weight Maintenance and Development of the Offspring Wolterbeek APM, Eussen SRBM, Jansink R, Van Der Horst JML, Otto M, Waalkens DH, Dijkkstra A, Salmon FGCH, Wortelboer HM, Pasman WJ, Hendriks HFJ, Bobeldijk I, Groten JP, De Groot DMG. TNO Quality of Life, Zeist, Netherlands.
8:00 AM - 12:00 AM	TS/NBTS JOINT SYMPOSIUM-Salon A
Recent Advances in Research on the Safety of Thimerosal in Vaccines Chair: Thomas Burbacher, University of Washington Introduction Speaker: Thomas M. Burbacher, University of Washington The Many Faces of Mercury Speaker: Thomas W. Clarkson, University of Rochester Thimerosal Kinetics in Infants Receiving Routine Vaccinations Speaker: Polly Sager, National Institute of Allergy and Infectious Diseases Animal Models of Thimerosal Absorption, Distribution, and Dealkylation Speaker: Thomas M. Burbacher, University of Washington Nanomolar Thimerosal Dysregulates Dendritic Cell Functions: Mechanisms and Ramifications Speaker: Issac N. Pessah, University of California, Davis Neurobehavioral Analysis of Early Postnatal Thimerosal Exposure in Mice Speaker: Robert F. Berman, University of California, Davis Neuroanatomical Correlates of Mercury Exposure Speaker: Jean Harry, National Institute of Environmental Health Sciences
9:30 AM - 10:00 AM	WARKANY TEA—Grand Ballroom Foyer Sponsored by Amgen, Inc.
10:00 AM - 12:00 PM	MARTA/MTA PEDIATRIC SYMPOSIUM—Catalina Ballroom
Pediatric Safety Evaluation: Regulatory, Nonclinical, and Clinical Experience Chair: Kok-Wah Hew, Emisphere Technologies, Inc. Pediatric Safety Evaluation Guidelines: What’s New Speaker: Shaun R. Maguire, GlaxoSmithKline Pediatric Safety Evaluation: Nonclinical Experience Speaker: Keith Robinson, Charles River Laboratories Preclinical Services–CTBR Translational Pediatric Research: Bridging the Gap From Preclinical to Clinical Setting Speaker: Daniel M. Jorgensen, Pfizer Global R&D Conducting Pediatric Clinical Trials: An Overview Speaker: Xilla Ussery, Pfizer Global R&D
10:00 AM - 12:00 PM	RARE DISEASES SYMPOSIUM—Salon B
Chemically Induced Congenital Anomalies: Is Oxidative Stress a Common Pathway? Chair: Peter G. Wells, University of Toronto Sponsored by the Office of Rare Diseases, National Institutes of Health, DHHS Introduction Speaker: Peter G. Wells, University of Toronto Oxidative DNA Damage and Repair in Teratogenesis Speaker: Peter G. Wells, University of Toronto Oxidative Stress and Signal Transduction in Chemical Teratogenesis Speaker: Jason Hansen, Emory School of Medicine Oxidative Stress in Diabetic Teratogenesis Speaker: Mary R. Loeken, Harvard University
12:00 PM - 1:00 PM	Education Committee Meeting—Executive Boardroom
12:00 PM - 1:00 PM	Lunch on Own
1:00 PM - 2:00 PM	RARE DISEASES ROUNDTABLE-Salon B
Chair: Melissa Tassinari, Pfizer, Inc. Speaker: Jean F. Campbell, National Organization for Rare Disorders, Inc.
2:00 PM - 5:00 PM	WILEY LISS SYMPOSIUM-Salon B
MicroRNAs in Vertebrate Development Chairs: Barbara F. Hales, McGill University and Philip Mirkes, Texas A&M University Introduction to MiRNA Speaker: Lance P. Ford, Ambion, Inc. Computational Identification of MiRNAs and Their Target Genes Speaker: Nikolaus Rajewsky, New York University MiRNAs as Regulators of C. elegans Development Speaker: Allison Abbott, Dartmouth Medical School Mammalian Small RNA Biology Speaker: Michael T. McManus, University of California - San Francisco
5:00 PM - 6:00 PM	BUSINESS MEETING AND REPORTS FROM BIRTH DEFECTS RESEARCH EDITORS-Salon B
6:30 PM - 11:00 PM	RECEPTION AND BANQUET-Kiva Ballroom
Thursday, June 29 top
7:00 AM - 7:30 AM	Coffee and Continental Breakfast-Grand Ballroom Foyer
7:00 AM - 10:00 AM	REGISTRATION-GrandBallroom Foyer
7:30 AM - 10:30 AM	PUBLIC AFFAIRS COMMITTEE PLATFORM SESSION-Salon B
Regulatory Science Chair: Anthony R. Scialli, Sciences International, Inc. Co-sponsored by the ILSI Health and Environmental Sciences Institute (HESI)–Developmental and Reproductive Toxicology Technical Committee The Effects of Serotonin Depletion on Locomotor Development in Zebrafish Airhart MJ1, Miller B1,2, Lee D1, Wilson T2, Miller M2, Skalko RG1. 1Dept. of Anatomy and Cell Biology, East Tennessee State University, Johnson City, TN, United States, 2Dept. of Psychiatry, East Tennessee State University, Johnson City, TN, United States.