2004 Meeting Highlights

Vancouver, British Columbia, Canada
June 26 - July 1, 2004

Registration Information

DATES TO REMEMBER:

February 13, 2004 Abstract Submission Deadline
May 28, 2004 Advance Registration Deadline
May 25, 2004 Hotel Reservation Deadline
June 1, 2004 Pre-Registration Deadline

• Meeting registration form
• Hotel registration request

Saturday, June 26	Sunday, June 27	Monday, June 28	Tuesday, June 29	Wednesday, June 30	Thursday, July 1
Education Course	Education Course continued	WARKANY LECTURE Carl L. Keen	Mini course: Epidemiology: The Basics	SPER/TS JOINT SYMPOSIUM - Epidemiology of Miscarriage	WILEY-LISS SYMPOSIUM - The Role of Neural Crest Cells
	SYMPOSIUM - Assisted Reproductive Technology (ART) and Reproductive Problems	Wilson Publication Award Presentation and Address	PUBLIC AFFAIRS COMMITTEE SYMPOSIUM NBTS/OTIS/TS JOINT SYMPOSIUM Birth Defects and Other Adverse Pregnancy Outcomes Due to Maternal Obesity	PLATFORM SESSION I - Mechanisms of Abnormal Development
	MATERNAL-FETAL MEDICINE Teratogenic Implication of Maternal Disease and its Treatment	SPECIAL LECTURE Fetal Determinants of Long Term Health Speaker: Judith Hall	Concurrent Symposium I - NBTS/TS JOINT SYMPOSIUM Neurobehavioral Outcomes of Common Exposures	PLATFORM SESSION II - Clinical Teratology and Epidemiology
	National Children's Study Update	Student Plenary Session and Posters and Exhibits open	Concurrent Symposium II - Pharmacokinetics and Metabolism in Pregnancy and Lactation - Consideration for Maternal Therapy and Fetal and Neonatal Risk	PLATFORM SESSION III - Title to be Determined
		Public Affairs Committee Workshop (Joint session with NTBS/OTIS/ TS)	Joint Teratology/ NBTS Poster Session II	Business Meeting
		CONCURRENT SYMPOSIUM I TS/OTIS JOINT SESSION Teratogen Update		Banquet Reception
		CONCURRENT SYMPOSIUM II Computational Systems Biology and Implications for Developmental Toxicology: From Molecules to Systems		Wilson and Fraser Banquet
		Issues Forum / Editor Reports
		JOINT TS/NBTS/OTIS POSTER SESSION I
		MARTA/MTA STUDENT CAREER EVENT

Saturday, June 26	top
9:00 AM - 12:00 NOON	COUNCIL 1A MEETING
11:30 AM - 5:00 PM	REGISTRATION
1:00 PM - 5:00 PM	EDUCATION COURSE PART 1 (separate registration required)
Signaling and Tissue Interactions in Organ-System Development Organized by the Education Committee, Michael G. Narotsky, Chairperson Sponsored by DuPont Haskell Laboratory and Endo Pharmaceuticals, Inc. Coursebooks provided by CTBR 1:00 PM – 1:10 PM Welcome – Rochelle W. Tyl, President, Teratology Society 1:10 PM – 1:15 PM Introduction Speaker: Michael G. Narotsky, U.S. EPA 1:15 PM – 2:00 PM Overview of Signaling and Development Speaker: Henk Roelink, University of Washington 2:00 PM – 2:45 PM Patterning Speaker: Claudia Kappen, University of Nebraska Medical Center 2:45 PM – 3:00 PM Break 3:00 PM – 3:45 PM Cellular, Molecular and Genetic Approaches to Study Cell Migration In Vivo Speaker: Vanessa Auld, University of British Columbia 3:45 PM – 4:30 PM Signaling and Tissue Interactions in Morphogenesis Speaker: Barbara Abbott, U.S. EPA
5:00 PM - 9:00 PM	COUNCIL 1B MEETING (Committee Reports)
Sunday, June 27 top
7:30 AM - 8:15 PM	EDUCATION COURSE CONTINENTAL BREAKFAST
8:00 AM - 5:00 PM	REGISTRATION
8:15 AM - 11:30 AM	EDUCATION COURSE PART II: (CONTINUED FROM SATURDAY)
Signaling Pathways and Tissue Interactions in Organ-System Development 8:15 AM – 9:00 AM Development of Bone and Cartilage Speaker: Rocky Tuan, NIH/NIAMS 9:00 AM – 9:45 AM Heart Development Speaker: Ida Smoak, North Carolina State University 9:45 AM – 10:00 AM Break 10:00 AM – 10:45 AM Patterning of the Gastrointestinal Tract and Derivatives Speaker: Drucilla Jane Roberts, Harvard Medical School 10:45 AM – 11:30 AM Signaling in Genitourinary Development Speaker: H. Scott Stadler, Oregon Health Sciences University
1:00 PM - 4:00 PM	MARCH OF DIMES SYMPOSIUM
RNA Interference (RNAi) Approaches to the Study of Normal and Abnormal Development Organized by Philip E. Mirkes, University of Washington; Jan Friedman, University of British Columbia, Vancouver; and Richard Finnell, Texas A&M University System Health Science Center Sponsored by March of Dimes Birth Defects Foundation Grant No. 4-FY03-138 1:00 PM – 1:05 PM Introduction Speaker: Philip E. Mirkes, University of Washington 1:05 PM – 1:40 PM S1 Enabling Developments in siRNA-Mediated Gene Silencing Speaker: Steve Daniel, Dharmacon RNA Technologies, Inc. 1:40 PM – 2:20 PM S2 RNAi in C. Elegans Speaker: TBA 2:20 PM – 2:40 PM Break 2:40 PM – 3:20 PM S3 MicroRNA Regulators of Cell Death in Development Speaker: Bruce Hay, California Institute of Technology 3:20 PM – 4:00 PM S4 Mus Musculus, RNAi and Development Speaker: Janet Rossant, Samuel Lunenfeld Research Institute
4:15 PM - 6:00 PM	MATERNAL-FETAL MEDICINE
Teratogenic Implication of Maternal Disease and its Treatment This session will address from the perinatologist’s perspective, two common maternal conditions that may have significant impact on fetal development. The presentations will focus on the effect on fetal development of treatment of the maternal disease as well as the disease itself. Moderator: Andy Hull, University of California, San Diego 4:15 PM – 4:25 PM Introduction Speaker: Andy Hull, University of California, San Diego 4:25 PM – 5:05 PM S5 Maternal Diabetes Speaker: Tom Moore, University of California, San Diego 5:05 PM – 5:45 PM S6 Hypertensive Disorders and Pregnancy Speaker: John Kingdom, Mount Sinai Hospital 5:45 PM – 6:00 PM Discussion
6:00 PM - 6:15 PM	NATIONAL CHILDREN'S STUDY UPDATE Speaker: Donald Mattison, NICHD
6:15 PM - 7:45 PM	WELCOMING RECEPTION AND EXHIBITS OPEN Sponsored by Bristol-Myers Squibb, MPI Research and RTI International
Monday, June 28 top
7:00 AM - 8:15 AM	BDR-B EDITORIAL MEETING
8:00 AM - 5:00 PM	REGISTRATION
8:00 AM - 8:10 AM	PRESIDENT'S WELCOME Rochelle W. Tyl
8:10 AM - 9:00 AM	THE JOSEF WARKANY LECTURE: Speaker: Carl L. Keen, University of California, Davis
9:00 AM - 9:45 AM	The James G. Wilson Publication Award Presentation and Address Neural and Orofacial Defects in Folbp 1 Knockout Mice Speaker: Richard H. Finnell, Texas A&M University System Health Science Center
10:00 AM - 11:00 AM	SPECIAL LECTURE Fetal Determinants of Long Term Health Speaker: Judith Hall, University of British Columbia, Vancouver
11:00 AM - 12:30 PM	Student Plenary Session
11:00 AM – 11:15 AM	The Effect of 2-agonists and Inhaled Corticosteroids Used to Treat Asthma in Pregnancy on Fetal Growth. L.N. Bakhireva, K.L. Jones, D.L. Johnson, G.R. Macaraeg, C.D. Chambers. Department of Pediatrics, University of California, San Diego, La Jolla, CA, United States.
11:15 AM – 11:30 AM	Cellular Anomalies Underlying Retinoid-Induced Phocomelia. J. Zhou, D.M. Kochhar. Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, United States.
11:30 AM – 11:45 AM	Evidence of Increased Birth Defects in the Offspring of Women Exposed to Valproate during Pregnancy: Findings from the AED Pregnancy Registry. R.M. Alsdorf1, D.F. Wyszynski1, L.B. Holmes2, M. Nambisan3. 1Boston University School of Medicine, Department of Medicine, Boston, MA, United States, 2Massachusetts General Hospital, Pediatric Service, Boston, MA, United States, 3Harvard Medical School, Department of Pediatrics, Boston, MA, United States.
11:45 AM – 12:00 PM	Teratogen Update: Potential Risks of Angiotensin II Receptor Antagonists during Pregnancy. S. Alwan1, J.E. Polifka2, J.M. Friedman1. 1Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada, 2Department of Pediatrics, University of Washington, Seattle, Washington, United States.
12:00 PM – 12:15 PM	The Role of Retinoic Acid Receptors Alpha 1 and Gamma in Retinoid-Induced Limb Dysmorphogenesis. E. Galdones1, D. Lohnes2, B.F. Hales1. 1McGill University, Department of Pharmacology & Therapeutics, Montreal, QC, Canada, 2Institut de Recherches Cliniques de Montreal, Montreal, QC, Canada.
12:15 PM – 12:30 PM	Activator Protein 1 (AP-1) DNA Binding Activity Is Induced in the Mouse Embryo during Organogenesis by Hydroxyurea (HU). J. Yan, B.F. Hales. McGill University, Department of Pharmacology & Therapeutics, Montreal, QC, Canada.
12:30 PM - 7:30 PM	POSTERS AND EXHIBITS OPEN
1:00 PM - 4:00 PM	CONCURRENT SYMPOSIUM I TS/OTIS JOINT SESSION
Teratogen Update Organized by Robert Brent, Alfred I. duPont Hospital for Children
1:00 PM - 1:05 PM	Introduction Speaker: Robert Brent, Alfred I. duPont Hospital for Children
1:05 PM - 1:35 PM	Genetic Polymorphisms: Impact on the Risk of FAS Speaker: Ting-Kai Li, National Institute on Alcohol Abuse and Alcoholism
1:35 PM - 2:05 PM	Update on the Risk of New Anticonvulsants Speaker: Lewis B. Holmes, Massachusetts General Hospital for Children
2:05 PM - 2:35 PM	Pesticides: The Risk of Birth Defects and Cancer Speaker: Rochelle W. Tyl, RTI International
2:35 PM - 2:50 PM	Break
2:50 PM - 3:20 PM	Trimethoprim Teratogenicity Speaker: Sonia Hernandez-Diaz, Slone Epidemiology Center, Boston University
3:20 PM - 3:50 PM	Trichloroethyelene (TCE) and Cardiac Teratogenicity Speaker: Robert Brent, Alfred I. duPont Hospital for Children
3:50 PM - 4:00 PM	Discussion
1:00 PM - 4:00 PM	CONCURRENT SYMPOSIUM II
Computational Systems Biology and Implications for Developmental Toxicology: From Molecules to Systems Organized by Robert Kavlock and Elaine Francis, U.S. EPA Sponsored by U.S. EPA
1:00 PM – 1:10 PM	Introduction Speaker: Robert Kavlock, U.S. EPA
1:10 PM – 1:40 PM	Computational Approaches for Predicting the Toxicological Effects of Xenobiotic Chemicals Speaker: William J. Welsh, RW Johnson Medical School
1:40 PM – 2:10 PM	Towards Understanding Development: Building a Model of the Early Sea Urchin Embryo Speaker: C. Titus Brown, California Institute of Technology
2:10 PM – 2:40 PM	Understanding Pathways of Toxicity: Making Sense of Changing Signals Speaker: Sid Hunter, U.S. EPA
2:40 PM ­ 3:00 PM	Break
3:00 PM ­ 3:30 PM	Network Models of EGF Receptor Signaling during Cell Organization and Differentiation Speaker: H. Steven Wiley, Pacific Northwest National Laboratory
3:30 PM ­ 4:00 PM	Birth Defects Systems Manager and Teratology Analyzer: A Beginning Speaker: Thomas Knudsen, University of Louisville
4:00 PM - 5:00 PM	ISSUES FORUM/EDITOR REPORTS
5:00 PM - 7:30 PM	JOINT TS/NBTS/OTIS POSTER SESSION I
7:30 PM - 10:30 PM	MARTA/MTA STUDENT CAREER EVENT
Tuesday, June 29 top
7:00 AM - 8:15 AM	BDR-A EDITORIAL MEETING
7:30 AM - 8:00 AM	MINI COURSE ATTENDEE CONTINENTAL BREAKFAST
8:00 AM - 5:00 PM	REGISTRATION
8:00 AM - 9:30 AM	MINI COURSE (Separate Registration Required)
Epidemiology: the Basics Organized by the Education Committee, Michael G. Narotsky, Chairperson Coursebooks provided by CTBR
8:00 AM ­ 8:45 AM	Clinical Epidemiology Speaker: Christina Chambers, University of California, San Diego
8:45 AM ­ 9:30 AM	Current Issues in Molecular Epidemiology Speaker: Andrew Olshan, University of North Carolina
9:30 AM - 12:00 NOON	PUBLIC AFFAIRS COMMITTEE SYMPOSIUM (NBTS/OTIS/TS JOINT SYMPOSIUM)
Birth Defects and Other Adverse Pregnancy Outcomes Due to Maternal Obesity Organized by James Mills, NICHD; Thomas Flynn, U.S. FDA; and Christina Chambers, University of California, San Diego Sponsored by the Teratology Society and NBTS
9:30 AM ­ 9:40 AM	Introduction Speaker: Thomas Flynn, U.S. FDA
9:40 AM ­ 10:05 AM	Neural Tube Defects & Other Birth Defects Associated with Maternal Obesity—Risks, Ethnic Variability, and Folic Acid Prevention Speaker: Gary Shaw, California Birth Defects Monitoring Program
10:05 AM ­ 10:30 AM	Maternal Obesity and Adverse Obstetrical Outcome Speaker: Joel Ray, University of Toronto
10:30 AM ­ 10:55 AM	Break
10:55 AM ­ 11:20 AM	Causes and Prevention of Maternal Obesity—Genetics, Regulation of Appetite, Suppression of Appetite, Strategies for Weight Loss Speaker: David Cummings, University of Washington
11:20 AM ­ 11:45 AM	The Epidemic of Obesity—National and International Policy and Strategic Approaches to Prevention Speaker: William Dietz, Centers for Disease Control
11:45 AM ­ 12:00 PM	Closing Remarks Speaker: James Mills, NICHD
12:00 PM - 1:00 PM	2005 PROGRAM COMMITTEE MEETING
12:30 PM - 7:30 PM	POSTERS AND EXHIBITS OPEN
1:00 PM - 4:30 PM	Concurrent Symposium I (NBTS/TS JOINT SYMPOSIUM)
Neurobehavioral Outcomes of Common Exposures Organized by Sherry Ferguson, National Center for Toxicological Research, U.S. FDA; and Kenneth Lyons Jones, University of California, San Diego
1:00 PM ­ 1:10 PM	Introduction Speaker: Sherry Ferguson, National Center for Toxicological Research, U.S. FDA
1:10 PM ­ 1:40 PM	Accutane Speaker: Jane Adams, University of Massachusetts
1:40 PM ­ 2:10 PM	Cocaine Speaker: Gale Richardson, University of Pittsburgh
2:10 PM ­ 2:40 PM	PCB Speaker: Sandra Jacobson, Wayne State University
2:40 PM ­ 3:00 PM	Break
3:00 PM ­ 3:30 PM	Alcohol Speaker: Claire D. Coles, Emory University School of Medicine
3:30 PM ­ 4:00 PM	Prozac Speaker: Sarah Mattson, San Diego State University
4:00 PM ­ 4:30 PM	Phenobarbital Speaker: Jane Adams, University of Massachusetts
1:00 PM - 4:30 PM	Concurrent Symposium II
Pharmacokinetics and Metabolism in Pregnancy and Lactation—Consideration for Maternal Therapy and Fetal and Neonatal Risk Organized by Dana L. Shuey, Endo Pharmaceuticals, Inc. Sponsored by Middle Atlantic Reproduction and Teratology Association and Midwest Teratology Association
1:00 PM ­ 1:10 PM	Introduction Speaker: Dana L. Shuey, Endo Pharmaceuticals, Inc.
1:10 PM ­ 1:55 PM	Ontogeny of Human Drug-Metabolism Speaker: Ronald Hines, Medical College of Wisconsin
1:55 PM ­ 2:40 PM	Metabolism and Drug Transporters in the Placenta Speaker: William Slikker, Jr., National Center for Toxicology Research
2:40 PM ­ 3:00 PM	Break
3:00 PM ­ 3:45 PM	Treating the Mother—Protecting the Unborn: Toward Rational Drug Therapy in Pregnancy Speaker: Gideon Koren, Hospital for Sick Children
3:45 PM ­ 4:30 PM	Transfer of Drugs and Chemicals into Human Milk: Rational Risk Assessment Speaker: Shinya Ito, Hospital for Sick Children
5:00 PM - 7:30 PM	Joint Teratology/NBTS Poster Session II
Wednesday, June 30 top
7:00 AM ­ 8:00 AM	Public Affairs Committee Meeting
7:00 AM ­ 8:00 AM	Publications Committee Meeting
8:00 AM - 5:00 PM	REGISTRATION
8:30 AM - 11:30 AM	SPER/TS JOINT SYMPOSIUM
Epidemiology of Miscarriage Goal: Examine the methods and current knowledge regarding the causes of miscarriage derived from epidemiology, with consideration of corresponding toxicology, measurement challenges, and future prospects for improved study. Organized by Christina Chambers, University of California, San Diego; Martha M. Werler, Slone Epidemiology Center; and David A. Savitz, University of North Carolina
8:30 AM ­ 8:40 AM	Introduction Speaker: Martha M. Werler, Slone Epidemiology Center, Boston University
8:40 AM ­ 9:05 AM	Animal Models for Studying Miscarriage—Illustration with Study of Drinking Water Disinfection By-Products Speaker: Michael G. Narotsky, U.S. EPA
9:05 AM ­ 9:30 AM	Genetic Causes of Miscarriage Speaker: Wendy P. Robinson, University of British Columbia
9:30 AM ­ 10:00 AM	Warkany Tea
10:00 AM ­ 10:25 AM	Autoimmune Causes of Miscarriage Speaker: Mary Stephenson, University of Chicago
10:25 AM ­ 10:50 AM	Epidemiologic Approaches to the Study of Early Miscarriage Speaker: Germaine Buck, NICHD
10:50 AM ­ 11:15 AM	Epidemiologic Evidence on Causes of Miscarriages: Illustration with Ongoing Study of Drinking Water Disinfection By-Products Speaker: David A. Savitz, University of North Carolina
11:15 AM ­ 11:45 PM	Closing Comments and Discussion Speaker: Christina Chambers, University of California, San Diego
11:45 AM - 1:15 PM	PAST PRESIDENTS' LUNCHEON (by invitation only)
1:00 PM - 5:00 PM	PLATFORM SESSIONS
PLATFORM SESSION I Mechanisms of Abnormal Development
1:00 PM ­ 1:15 PM	Laser Capture Microdissection and Gene Array Analysis of Palatal Epithelial and Mesenchymal Cells Exposed to TCDD. B.D. Abbott, J.E. Schmid. Repro.Tox.Div., U.S. EPA, Research Triangle Park, NC, United States.
1:15 PM ­ 1:30 PM	Alterations in Biotin-Dependent Carboxylases in Fetal and Maternal Liver Induced by Biotin Deficiency. D.K. Hansen1, S.L. Stratton2, W.M. Sealey2, D.M. Mock2. 1National Center for Toxicological Research, Division of Genetic and Reproductive Toxicology, Jefferson, AR, United States, 2University of Arkansas for Medical Sciences, Department of Biochemistry and Molecular Biology, Little Rock, AR, United States.
1:30 PM ­ 1:45 PM	The Progressive Effects of Heat Stress on Somitogenesis and Other Developing Tissues in the Rat. K.E. Wheeler1, G.L. Kimmel2, T.W. Claggett3, C.A. Kimmel4. 1Orise Fellow U.S. FDA Center for Devices and Radiological Health, Rockville, MD, United States, 2Visiting Scientist, U.S. FDA, Rockville, MD, United States, 3Charles River Laboratories, Frederick, MD, United States, 4National Center for Environmental Assessment/ORD, U.S. EPA, Washington, DC, United States.
1:45 PM ­ 2:00 PM	Beneficial Effect of Folate in Two Genetic Models of Aberrant Skeletal Development. C. Kappen, C. Kruger, C. Talmadge, J.M. Salbaum. University of Nebraska Medical Center, Department of Genetics, Cell Biology and Anatomy, Omaha, NE, United States.
2:00 PM ­ 2:15 PM	Intra Uterine Growth Restriction: A Unique Experimental Rat Model Combining Genetic and Environmental Causative Factors. M. Avgil1, R.K. Miller2, A. Ornoy1. 1Hebrew University Hadassah Medical School, Jerusalem, Israel, 2School of Medicine and Dentistry, University of Rochester, Rochester, NY, United States.
2:15 PM ­ 2:30 PM	In Utero and Lactational Exposures to Low Dose PBDE 47 Cause Neurobehavior Disturbances in Rat Offspring. S.N. Kuriyama, C.E. Talsness, I. Chahoud. Institute of Clinical Pharmacology and Toxicology, Charoté University Medical School Berlin, Campus Benjamin Franklin, Berlin, Germany.
2:30 PM ­ 2:45 PM	Altered Gene Expression of Mouse Embryo Cultures Exposed to Bromochloroacetic Acid. E.D. Karoly1, J.E. Schmid2, M.R. Blanton2, E.S. Hunter III2. 1University of North Carolina at Chapel Hill, Curriculum in Toxicology, Chapel Hill, NC, United States, 2U.S. EPA, Reproductive Toxicology Division, Research Triagle Park, NC, United States.
2:45 PM ­ 3:00 PM	Phospholipase C Signaling in Ethanol-Induced Apoptosis during Early Embryo Development. A. Garic-Stankovic1, M. Hernandez1, K.A. Kragtorp-Debelak1, D.R. Armant2, S.M. Smith1. 1Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, United States, 2Department of Obstetrics & Gynecology; Wayne State University, Detroit, MI, United States.
3:00 PM ­ 3:15 PM	Break
3:15 PM ­ 3:30 PM	Cell Death and Developmental Timing Are Critical Determinants of Facial Dysmorphology in the Chick Model of Prenatal Alcohol Exposure. K.A. Kragtorp-Debelak, M. Moyers, A. Garic-Stankovic, S.M. Smith. Dept. Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, United States.
3:30 PM ­ 3:45 PM	Fumonisin, Folate, and Neural Tube Defects: Novel Mechanisms Involving TNF? Signaling and Redox Homeostasis. J. Gelineau-Van Waes, L. Starr, J. Wilberding, F. Aleman, J. Maddox. Dept. Genetics, Cell Biology & Anatomy, University of Nebraska Medical Center, Omaha, NE, United States.
3:45 PM ­ 4:00 PM	The Role of Hypoxia-Inducible Factor-1 (HIF-1 Alpha) in Mouse Limbs Exposed to 4-Hydroperoxycyclophosphamide In Vitro. C. Huang, B.F. Hales. McGill University, Department of Pharmacology & Therapeutics, Montreal, QC, Canada.
4:00 PM ­ 4:15 PM	Role of P53 in Regulation of Cell Death and Cell Survival in Teratogen Treated Day 9 Mouse Embryos. S.A. Little, P.E. Mirkes. University of Washington, Department of Pediatrics, Seattle, WA, United States.
4:15 PM ­ 4:30 PM	Disruption of Heart Development by Trichloroethylene, a Common Groundwater Contaminant. V.J. Drake1, S.L. Koprowski2, J.W. Lough2, S.M. Smith1. 1Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, United States, 2Department of Cell Biology, Anatomy and Neurobiology, Medical College of Wisconsin, Milwaukee, WI, United States.
4:30 PM ­ 4:45 PM	The Impact of Pax3 and Cystathionine Beta Synthase Mutations on Arsenic Induced Birth Defects. E.K. Marshall1, A.F. Machado2, A.F. Elsaid3, M.D. Collins1. 1Univerity of California Los Angeles, Department of Environmental Health Sciences, Los Angeles, CA, United States, 2California State University, Northridge, Department of Environmental and Occupational Health, Northridge, CA, United States, 3University of California Los Angeles, Interdepartmental Program in Molecular Toxicology, Los Angeles, CA, United States.
4:45 PM ­ 5:00 PM	Amelioration of Vitamin A-Induced Malformations in the Mid-Organogenesis-Stage Mouse Limb Bud by A Retinoic Acid Receptor Alpha and Gamma Selective Antagonist. S.E. Ali-Khan, B.F. Hales. McGill University, Department of Pharmacology and Therapeutics, Montreal, Quebec, Canada.
Platform Session II Clinical Teratology and Epidemiology
1:00 PM ­ 1:15 PM	Hypospadias and Maternal Intake of Progestins and Oral Contraceptives. S.L. Carmichael1, G.M. Shaw1, C. Laurent1, M. Croughan4, R.S. Olney2, E.J. Lammer3. 1MOD/CA Birth Defects Monitoring Program, Berkeley, CA, United States, 2CDC/NCBDDD, Atlanta, GA, United States, 3Children’s Hospital Research Institute, Oakland, CA, United States, 4UCSF, San Francisco, CA, United States.
1:15 PM ­ 1:30 PM	Ultrasound Imaging of the Neonatal Corpus Callosum Is Feasible and Useful. F.L. Bookstein, A.P. Streissguth, C. Gleason, T. Lalani, P.D. Connor, T. Keener, K. Baldwin, W.D.K. Green. University of Washington, Fetal Alcohol and Drug Unit, Seattle, WA, United States.
1:30 PM ­ 1:45 PM	Autism and Ocular Malformations in CHARGE Association and Goldenhar Syndrome. K. Strömland1, M. Miller2, M. Johansson3, S. Danielsson3, E. Billstedt3, C. Gillberg3, B.M. Ekman-Joelsson4. 1Pediatric Ophthalmology, Göteborg University, Göteborg, Sweden, 2Ophthalmology, University of Illinois, Chicago, United States, 3Child Neuropsychiatry, Göteborg University, Göteborg, Sweden, 4Pediatrics, Skövde, Sweden.
1:45 PM ­ 2:00 PM	Different Fetal Effects of Three Anticonvulsant Drugs on Skull and Face. D. Doan2, L.A. Will2, L.B. Holmes1. 1Genetics & Teratology Unit, Pediatric Service, Massachussets General Hospital, Boston, MA, United States, 2Department of Growth and Development, Harvard School of Dental Medicine, Boston, MA, United States.
2:00 PM ­ 2:15 PM	Change in Paternity As a Risk Factor for Gastroschisis. C.D. Chambers1, B.H. Chen1, K.A. Kalla2, K.L. Jones1. 1University of California, San Diego, La Jolla, CA, United States, 2Kaiser Permanente Medical Center, San Diego, CA, United States.
2:15 PM ­ 2:30 PM	Assisted Reproductive Techniques and the Risk of Oral Clefts: Data from the National Birth Defects Prevention Study, 1997­2000. J. Reefhuis1, M. Honein1, S. Rasmussen1, A. Correa1, C. Hobbs2, A. Scheuerle3, L. Schieve4. 1National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, GA, United States, 2University of Arkansas for Medical Sciences, Little Rock, AR, United States, 3Texas Department of Health, Austin, TX, United States, 4National Center for Chronic Disease Prevention and Health Promotion, CDC, Atlanta, GA, United States.
2:30 PM ­ 2:45 PM	Maternal Obesity and Cardiovascular Malformations. A. Correa-Villaseñor, C.J. Alverson. CDC, NCBDDD, Atlanta, GA, United States.
2:45 PM ­ 3:00 PM	Maternal Diabetes and Cardiovascular Malformations. M.K. Thong2, A. Correa-Villaseñor1, C.J. Alverson1. 1CDC, NCBDDD, Atlanta, GA, United States, 2University of Malay, Department of Pediatrics, Kuala Lumpur, Malaysia.
3:00 PM ­ 3:15 PM	Break
3:15 PM ­ 3:30 PM	Diabetes, Body Mass Index, Vitamin Supplementation, and Anotia/Microtia. M.M. Werler, J.E. Sheehan, A.A. Mitchell. Slone Epidemiology Center at Boston University, Boston, MA, United States.
3:30 PM ­ 3:45 PM	Impact of Maternal Alcohol Consumption on Sonographically­Visualized Fetal Brain Anatomy. N.S. Handmaker2, W.F. Rayburn1, C. Meng2, B.B. Rayburn1, A. Wodajo2, V. Rappaport1. 1University of New Mexico, Obstetrics & Gynecology, Albuquerque, NM, United States, 2University of New Mexico, Psychology, Albuquerque, NM, United States.
3:45 PM ­ 4:00 PM	Placental Abnormalities Associated with Misoprostol Administration. K.K. Vaux1, C.H. Chambers1, R. Chamit2, K. Benirschke3, E. Vanazzi4, K.L. Jones1. 1University of California, Department of Pediatrics, San Diego, CA, United States, 2University of California, San Diego, Department of Reproductive Medicine, San Diego, CA, United States, 3University of California, San Diego, Department of Pathology, San Diego, CA, United States, 4Universitat San Pablo, San Pablo, Brazil.
4:00 PM ­ 4:15 PM	Alcohol Dehydrogenase 3 Genotype and Risk for Oro-facial Clefts: Role of the Maternal and Fetal Genotypes. C. Chevrier1, C. Perret2, A. Nelva3, C. Herman4, E. Robert-Gnansia5, M. Bahuau6, C. Francannet6, S. Cordier6. 1INSERM U435, Rennes, France, 2INSERM U 525, Faculté de médecine Pitié-Salpétrière, Paris, France, 3IEG, Lyon, France, 4CEMC Auvergne, Clermont-Ferrand, France, 5Service de Chirurgie Maxillo-faciale, Hôpital Trousseau, Paris, France, 6Service de Pédiatrie B, Hôtel-Dieu, Clermont-Ferrand, France.
4:15 PM ­ 4:30 PM	Evaluation of the Teratogenicity of Homocysteine in Rat Embryos Cultured In Vitro. L.B. Fawcett, J.E. Pugarelli, R.L. Brent. Alfred I. duPont Hospital for Children, Department of Biomedical Science, Wilmington, DE, United States.
4:30 PM ­ 4:45 PM	Neurdevelopmental Outcome of Infants and Toddlers Exposed Prenatally to Selective Serotonin Reuptake Inhibitors. S.N. Mattson1, K.E. Calarco1, K.K. Kao2, K.L. Jones2, C.D. Chambers2. 1Center for Behavioral Teratology, Deparment of Psychology, San Diego State University, San Diego, CA, United States, 2California Teratogen Information Service and Clinical Research Program, Department of Pediatrics, University of California, San Diego, San Diego, CA, United States.