| Saturday, June 22 |
| |
|
| 1:15
PM - 4:30 PM |
EDUCATION
COURSE |
Mechanisms,
Biomarkers, Data Interpretation: An Integrative Risk Assessment
Using Developmental Neurotoxicity as a Model
|
- Use
of mechanistic data in risk assessment
|
Carole
Kimmel,
USEPA |
- General
overview of pre & postnatal nervous system development
|
John
DeSesso,
Mitretek Systems |
- Molecular
markers of nervous system development and toxicity
|
James
P. O,Callaghan,
CDC/NIOSH |
- Functional
markers of nervous system development and manifestations
of toxicity
|
Patricia
Rodier,
University of Rochester |
|
|
| 8:15
AM - 11:30 AM |
EDUCATION
COURSE (CONTINUED FROM SATURDAY) |
- Developmental
neurotoxicity: Testing and data interpretation (focus
on practical and logistical considerations, data interpretation
and challenges)
|
Abby
A. Li, Monsanto
Company |
- Examination
of the effects of chlorpyrifos on developmental processes:
evaluation of biochemical, morphological and behavioral
indices of developmental neurotoxicity
|
Stan
Barone,
USEPA |
- Integrative
risk assessment: BBDR modeling
|
Elaine
Faustman,
University of Washington |
- Panel
discussion. Beginning with set of predetermined questions
related to applications of mechanistic information in
applied research, testing and risk assessment
|
Facilitator:
Joseph Holson, WIL Research Laboratories, Inc. |
| 1:00
PM - 4:30 PM |
MARCH
OF DIMES SYMPOSIUM |
The
Application of Proteomics to Developmental Toxicology
|
| |
Patrick
Wier,
GlaxoSmithKline |
- Mining
proteomic diversity with LC-MS and the SALSA algorithm
|
Daniel
C. Liebler,
University of Arizona |
- Direct
profiling of proteins in biological tissue sections
by MALDI mass spectrometry
|
David
L. Hachey,
Vanderbilt University |
- Qualitative
and quantitative proteomics without polyacrylamide
|
David
Goodlett,
The Institute for Systems Biology, University of
Washington |
- Spot
the difference: The effects of hypoxia on the cytotrophoblast
protein repertoire
|
Van
Hoang,
National Cancer Institute |
- Student
Discussions with MOD Symposium Speakers
|
|
| 5:00
PM - 6:00 PM |
ISSUES
FORUM |
| 5:00
PM - 7:30 PM |
EXHIBITS
OPEN |
| 6:00
PM - 7:30 PM |
WELCOMING
RECEPTION |
|
|
| 8:00
AM 9:00 AM |
WARKANY LECTURE
From recognition to responsibility: David Smith, Josef Warkany
and the fetal alcohol syndrome in the 21 st century.
Speaker:
Kenneth Lyons
Jones |
| 9:00
AM - 10:00 AM |
Wilson
Publication Award Presentation and Address |
| 10:00
AM - 12:00 PM |
Student
Plenary Session and Platform Award Competition
Chairpersons:
Janet Urui-Adams, University of California, Davis,
and Jack Bishop, NIEHS |
| 12:15
PM - 1:00 PM |
The
Great Debate: Is there an all or none phenomenon in Teratology?
Moderator:
Mason Barr, University of Michigan
Presenters:
Robert Brent, DuPont Hospital for Children and Joe
Rutledge, University of Washington |
| 1:30
PM 4:45 PM |
PUBLIC
AFFAIRS SYMPOSIUM |
Methylmercury:
From Minamata Bay to Current Policy Implementation
|
- Historical
Methylmercury Exposure and Developmental Toxicity
|
Kenneth
Reuhl, Rutgers
University |
- Recent
Studies on the Health Effects of Methylmercury
|
David
Bellinger, Harvard
University |
- EPA
Hazard Assessment for Methylmercury Relies on Recent
Epidemiological Studies
|
Deborah
Rice, USEPA |
- Management
and Communication of Risk: The Maine Experience
|
Andrew
E. Smith, Maine |
| 5:00
PM - 7:30 PM |
Joint
TS/NBTS/OTIS Poster Session I |
| 7:30
PM - 10:30 PM |
Student
Career Event |
|
|
| 7:00
AM - 8:15 AM |
Mini
course: Experimental design and biostatistics |
- Basic
Statistical Analysis of Developmental Toxicity Studies
|
Instructor:
Woody Setzer, USEPA |
- Evaluation
of Post-natal Developmental Outcomes: Study Design Considerations
for Endocrine Active Chemicals.
|
Instructor:
Paul Foster, CIIT Centers for Health Research |
| 8:30
AM -11:45 AM |
NBTS/OTIS/Teratology
Society/European Teratology Society Joint Symposium |
Children's Health and Environmental Chemical Exposures:
Prediction of Risk from Animal Models and Clinical Studies
|
- The
role of the environment in the neurodevelopmental modulation
in children exposed in utero to illicit drugs or maternal
diseases
|
Asher
Ornoy, Hebrew
University |
- Developmental
outcome of children exposed in utero to antiepileptic
drugs
|
Lew
Holmes, Massachusetts
General Hospital and Jane Adams, University of Massachusetts |
- Use
of identical behavioral tasks in children and nonhuman
primates for studying chemical effects on a variety
of complex brain functions
|
Merle
Paule, NCTR |
- Use
of imaging techniques to explore neural substrates associated
with prenatal alcohol syndrome
|
Elizabeth
R. Sowell, UCLA |
| 12:00
- 12:45 PM |
"TERATOLOGY:
BIG PICTURE PERSPECTIVE"
Bernard
Schwetz, Acting
Principal Deputy Commissioner FDA |
| 1:00
PM - 4:00 PM |
TERATOGEN
UPDATE, (TS/OTIS Joint Session) |
- Caffeine
- a human teratogen?
|
Mildred
Christian,
Argus Research, a division of Charles River Laboratories |
- Cholesterol
lowering drugs (the statins)
|
Robert
Brent,
DuPont Hospital for Children |
| |
Andrew
Hendrickx,
California Regional Primate Research Center |
| |
Janine
Polifka,
University of Washington |
| 5:00
PM - 7:30 PM |
Joint
Teratology/NBTS Poster Session II |
|
Concurrent
Sessions |
| 8:30
AM - 11:30 AM |
THE
USE OF NONHUMAN PRIMATE MODELS IN DEVELOPMENTAL TOXICOLOGY
STUDIES |
- The
Non-Human Primate Model in Reproductive Toxicology with
Special Emphasis on Male Fertility Testing
|
Walter
H. Bee, Charles
River Laboratories |
- Chronic
Uterine and Vascular Female Catheterization Techniques
and Opportunities for Investigative Studies
|
George
J. Haluska,
Oregon Regional Primate Research Center |
- Female
Reproduction and Prenatal Development of the Immune
System in Macaques
|
Andrew
G. Hendrickx,
California Regional Primate Research Center |
- Preclinical
Development Strategy for Testing Effects of Immune Modulating
HuMAb in Reproduction in Non-human Primates
|
Corine
K. Klingbeil, Protein
Design Labs, Inc. |
- Neurobehavioral
Testing in the Rhesus Monkey
|
Nellie
K. Laughlin, University
of Wisconsin |
| 8:30
AM - 11:30 AM |
THE
DIRECT DOSING OF PRE-WEANING MAMMALS IN TOXICITY TESTING |
- General
experimental design issues in direct dosing of pre-weaning
mammals
|
Sue
Makris,
USEPA |
- Direct
dosing of pre-weaning rodents
|
Susan
Barron,
University of Kentucky |
- Direct
dosing of pre-weaning pigs, dogs and primates
|
Larry
Garthoff, CFSAN/FDA |
- Direct
dosing of Pre-Weaning Mammals. Panel Discussion
|
Chaired
by Isabel Walls, ILSI
Panelists: Sue Makris, Susan Barron, Larry Garthoff,
David Beckman, Tom Sobotka, CFSAN/FDA |
| 8:30
AM - 11:30 AM |
MICROARRAY
DATA ANALYSIS AND BIOINFORMATICS WORKSHOP (Sponsored by Perkin-Elmer
Life Sciences) |
- Standards
and practices of microarray analysis in developmental
biology and developmental toxicity
|
Tom
Knudsen, Jefferson
Medical College and George P. Daston, Procter &
Gamble Company, Miami Valley Laboratories |
- Toxicogenomics:
use of a data set of toxicant-induced transcriptional
profiles to derive signature patterns associated with
mode of action
|
Mark
Johnson, Robert
Wood Johnson Pharmaceutical Research Institute |
- Bioinformatics
pipeline and its information resources
|
Sylvia
J. Spengler,
Lawrence Berkeley National Laboratory |
- Morphant-based
gene knockdown
|
Stephen
C. Ekker,
University of Minnesota |
| 12:00
- 12:45 PM |
"PREVENTING
BIRTH DEFECTS THROUGH PUBLIC POLICY"
Jose
Cordero, Director
National Center on Birth Defects and Developmental Disabilities,
CDC |
| 1:00
PM - 5:00 PM |
PLATFORM
SESSIONS
(3 Concurrent Sessions) Selected from submitted abstracts
Clinical
Teratology and Epidemiology
Abnormal
Development
Hazard
and Risk Evaluation |
| 5:00
PM - 6:00 PM |
BUSINESS
MEETING |
| 7:00
PM - 8:00 PM |
BANQUET
RECEPTION |
| 8:00
PM |
BANQUET |
|
|
| 8:30
AM - 11:30 AM |
The
Wiley-Liss Symposium |
Immunotoxicology: Principles and Applications to Developmental
Toxicity Studies
|
- The
Postnatal Immune System as a Target for Teratogens/
Developmental Toxicants from Perinatal Exposures
|
Michael
Luster, CDC,
NIOSH |
- In
Utero and Postnatal Development of the Immune System
|
Ralph
J. Smialowicz, USEPA,
NHEERL |
- Windows
of Differential Immunotoxic Sensitivities during Development:
Phylogenetic and Sub-population Considerations
|
Rodney
R. Dietert, Cornell
Univ. |
- The
Effect of the Maternal Immune System on Teratogenicity
|
Steven
D. Holladay,
VA-MD Regional College of Veterinary Medicine, Virginia
Polytechnic Institute and State University |