1:00 pm å 1:05 pm

WELCOME Robert Kavlock, President, Teratology Society

1:05 pm å 1:10 pm

INTRODUCTION Kok-Wah Hew, Chairman, Education Committee

1:15 pm å 2:00 pm

A REVIEW OF THE PRINCIPLES OF TERATOLOGY: The Foundation to New Mechanistic Technologies
Speaker: James Schardein, Mansfield, Ohio

2:00 pm å 2:45 pm

TECHNOLOGIES TO ANALYZE TERATOGENIC MECHANISMS
Speaker: Thomas Knudsen, Department of Pathology, Anatomy & Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania

2:45 pm å 3:30 pm

GENE-TERATOGEN INTERACTION: GENOTYPE-RELATED SUSCEPTIBILITY DURING DEVELOPMENT
Speaker: Simon Ward, Division of Genomic Medicine, Royal Hallamshire Hospital, University of Sheffield Medical School, Sheffield, S. Yorks, United Kingdom

3:30 PM å 3:45 PM

BREAK

3:45 pm å 4:30 pm

APOPTOSIS: CELL-SPECIFIC SUSCEPTIBILITY DURING DEVELOPMENT
Speaker: Philip E. Mirkes, Department of Pediatrics, University of Washington, Seattle, Washington

4:30 pm å 5:15 pm

LIMB DEVELOPMENT: untying the gordian knot with new ideas and technologies
Speaker: Bruce Carlson, Institute of Gerontology, University of Michigan, Ann Arbor, Michigan

8:15 Am å 9:00 am

SPATIOTEMPORAL PATTERNS OF GENE EXPRESSION: DEVELOPMENTAL STAGE-RELATED SUSCEPTIBILITY
Speaker: John Rogers, Reproductive Teratology Division, USEPA, Research Triangle Park, North Carolina

9:00 am å 9:45 am

REACTIVE INTERMEDIATES AND ABNORMAL DEVELOPMENT: AGENT-SPECIFIC SUSCEPTIBILITY
Speaker: Peter Wells, University of Toronto, Toronto, Ontario

9:45 AM å 10:00 AM

BREAK

10:00 am å 10:45 am

REVISITING DOSE-DEPENDENT RELATIONSHIPS FOR TERATOGENS
Speaker: Elaine Faustman, Department of Environmental Health, University of Washington, Seattle, Washington

10:45 am å 11:30 am

CURRENT KNOWLEDGE OF ABNORMAL DEVELOPMENT: AN OVERVIEW
Speaker: William Scott, ChildrenÁs Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio

Organized by Barbara Hales, Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Andrew F. Olshan, Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina, and Donald Mattison, Medical Director, March of Dimes, White Plains, New York

2:00 pm å 2:10 pm

INTRODUCTION Barbara Hales

2:10 pm å 2:45 pm

THE HUMAN STORY WHERE ARE WE NOW?
Speaker: Andrew F. Olshan, Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina

2:45 pm å 3:20 pm

DETECTING ADVERSE EFFECTS ON THE PATERNAL GENOME
Speaker: Sally Perreault Darney, Reproductive Toxicology Division, USEPA, Research Triangle Park, North Carolina

3:20 PM å 3:40 PM

BREAK

3:40 pm å 4:15 pm

EFFECTS ON PROGENY OUTCOME HUMAN AND ANIMAL STUDIES TO ELUCIDATE MECHANISMS
Speaker: Andrew J. Wyrobek, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, California

4:15 pm å 4:50 pm

ARE THERE APPROPRIATE BIOMARKERS OF PATERNAL DRUG EXPOSURE THAT PREDICT ALTERED PROGENY OUTCOME?
Speaker: Bernard Robaire, Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec

4:50 pm å 5:00 pm

CLOSING REMARKS
Donald Mattison, Medical Director, March of Dimes, White Plains, New York

9:30 am å 10:30 am

OVERVIEW OF THE BIOLOGY OF PLURIPOTENT STEM CELLS OVERVIEW
Speaker: Peter Donovan, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania

10:30 am å 10:50 am

BREAK

10:50 am å 11:40 am

APPLICATION OF EMBRYONIC STEM CELLS AS RESEARCH TOOLS TO ADDRESS FUNDAMENTAL PROCESSES IN DEVELOPMENTAL TOXICITY
Speaker: Horscht Spielmann, ZEBET, Berlin, Germany

11:40 am å 12:30 pm

ISSUES IN THE BIOETHICS OF PLURIPOTENT STEM CELLS
Speaker: Laurie Zoloth, College of Humanities, San Francisco State University, San Francisco, California

2: 45 pm å 3:00 pm

NON-ACIDEMIC ISCHEMIA THE FETAL NEUROLOGICAL TERATOGEN
R. Quintero and B.S. Schifrin, Department of Obstetrics & Gynecology, Glendale Adventist Medical Center, Glendale, California

3:00 pm å 3:15 pm

REGULATION OF THE C-JUN MITOGEN-ACTIVATED PROTEIN KINASE PATHWAY IN HYPERTHERMIA-EXPOSED DAY 9 MOUSE EMBRYOS
F.M. Bautista, L.C. Cornel, S.A. Little, and P.E. Mirkes, University of Washington, Seattle, Washington

3:15 pm å 3:30 pm

Break

3:30 pm å 3:45 pm

PAX3: CONTROL OF DNA BINDING BY REDOX STATUS, METALS AND NITROGEN OXIDE SPECIES
A.F. Machado and M.D. Collins, UCLA, Los Angeles, California

3:45 pm å 4:00 pm

PREVENTION OF RETINOIC ACID-INDUCED CLEFT PALATE IN MICE BY SEPARATE OR CONCOMITANT ADMINISTRATION OF FOLATE AND METHIONINE
P.R. Reynolds, G.B. Schaalje and R.E. Seegmiller, BYU, Provo, Utah

4:00 pm å 4:15 pm

AN OXYGEN SENSING SWITCH FOR EMBRYONIC REGULATION OF MITOCHONDRIAL BIOGENESIS
M.F. OÁHara, J.H. Charlap, R.C. Craig and T.B. Knudsen, Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, Philadelphia, Pennsylvania

4:15 pm å 4:30 pm

EXPRESSION OF URACIL DNA GLYCOSYLASE, A DNA REPAIR ENZYME, IN THE ORGANOGENESIS-STAGE RAT CONCEPTUS.
R.K. Vinson and B.F. Hales, McGill University, Montréal, Canada

9:00 am å 9:10 AM

INTRODUCTION
Patty Rodier

9:10 am å 9:50 AM

NEUROBEHAVIOURAL CONSEQUENCES OF X-CHROMOSOME DELETIONS: IMPLICATIONS FOR AUTISM
Speaker: D.H. Skuse, S. Thomas, J. Kuntsi, K. Elgar, and P.A. Jacobs, Behavioural Sciences Unit, London, United Kingdom; and Wessex Regional Genetics Laboratory, Salisbury, United Kingdom

9:50 am å 10:30 AM

COGNITIVE PHENOTYPE IN CHILDREN WITH SPINA BIFIDA AND HYDROCEPHALUS
Speaker: M. Dennis, Department of Psychology, The Hospital for Sick Children Toronto, Ontario

10:30 AM å 10:50 AM

BREAK

10:50 am å 11:20 AM

ON THE RELATION BETWEEN HINDBRAIN MALDEVELOPMENT, CLINICAL FEATURES, AND NEUROBEHAVIOR IN JOUBERT SYNDROME AND DANDY-WALKER SYNDROME
Speaker: B.L. Maria, Department of Pediatrics, Neurology and Neuroscience, University of Florida College of Medicine, Gainesville, Florida

11:20 am å 12:00 PM

PSYCHIATRIC ILLNESSES IN ADULTS WITH 22Q DELETION SYNDROME
Speaker: A.S. Bassett, Dept. of Psychiatry, Centre for Addiction & Mental Health and University of Toronto, Toronto, Canada

9:00 am å 9:15 am

INTRODUCTION Karen Filkins

9:15 am å 10:00 am

CHORIONIC VILLUS SAMPLING
Speakers: Lew Holmes1, and Karen Filkins2. 1Genetics and Teratology Unit, Massachusetts General Hospital, Boston, Massachusetts; and 2Department of Obstetrics and Gynecology, UCLA School of Medicine, Los Angeles, California

10:00 am å 10:30 am

EARLY AMNIOCENTESIS
Speaker: Douglas Wilson, Department of Obstetrics and Gynecology, ChildrenÁs & WomenÁs Hospital, University of British Columbia, Vancouver, British Columbia

10:30 AM å 10:45 AM

BREAK

10:45 am å 11:15 am

PERCUTANEOUS UMBILICAL ARTERY SAMPLING (PUBS), REPRODUCTIVE TECHNOLOGIES, AND FETAL REDUCTION PROCEDURES
Speaker: Ron Wapner, MCP Hahnemann School of Medicine, MCP Hahnemann University, Philadelphia, Pennsylvania

11:15 am å 11:30 am

FETAL SURGERY
Speaker: Karen Filkins, Department of Obstetrics and Gynecology, UCLA School of Medicine, Los Angeles, California

11:30 am å 12:00 pm

BRACHIAL PLEXUS INJURY: AN IN UTERO PHENOMENON
Speaker: T.M. Goodwin, Maternal Fetal Medicine, University of Southern California, Los Angeles, California

12:00 Pm å 12:30 Pm

CONDUCT OF THE SECOND STAGE OF LABOR: OBSTETRICAL CHOICES AND THE RISK OF NEUROLOGIC INJURY
Speaker: Barry Schifrin, Tarzana, California

2:00 pm å 2:15 pm

RETINOIC ACID (RA) REGULATION OF GENES INVOLVED IN THE INDUCTION OF PROXIMODISTAL LIMB REDUCTION DEFECTS, AS ANALYZED BY MICROARRAY
R. Cimildoro1, P. Qin2, D.R. Soprano2 and D.M. Kochhar1. 1Thomas Jefferson University, Philadelphia, Pennsylvania; 2Temple University School of Medicine, Philadelphia, Pennsylvania

2:15 pm å 2:30 pm

LOCALIZATION OF RETINOIC ACID-INDUCED APOPTOSIS IN THE ORGANOGENESIS STAGE MOUSE LIMB BUD
S.E. Ali-Khan and B.F. Hales, McGill University, Montréal, Québec, Canada

2:30 pm å 2:45 pm

IN UTERO VALPROIC ACID EXPOSURE ALTERS HOXA1 EXPRESSION IN THE RAT EMBRYO: MECHANISM OF TERATOGENICITY AND RELATIONSHIP TO AUTISM
C. Stodgell, J. Ingram, S. Gnall, and P. Rodier, University of Rochester, Rochester, New York

2:45 pm å 3:00 pm

TOXICOGENOMIC ANALYSIS OF THE EMBRYONIC RESPONSE TO METHYLMERCURY
T.B. Knudsen, J.H. Charlap, R.C. Craig, J. Lee, E. Cho and M.F. OÁHara, Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, Philadelphia, Pennsylvania

3:00 pm å 3:15 pm

MOLECULAR FINGERPRINT OF ESTROGEN ACTION IN THE FETAL RAT UTERUS
J.M. Naciff, M.L. Jump, S.M. Torontali, J.P. Tiesman, and G. P. Daston, Miami Valley Laboratories, Procter & Gamble, Cincinnati, Ohio

3:15 pm å 3:30 pm

BREAK

3:30 pm å 3:45 pm

DEFECTIVE SIALYLATION IN SP2H MUTANT EMBRYOS
K. Glogarova and D. Buckiova, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic

3:45 pm å 4:00 pm

CU DEFICIENCY INDUCES OXIDATIVE DAMAGE IN MOUSE EMBRYOS
L. Lanoue, M.E. Beckers, C.L. Keen, R.B. Rucker and J.Y. Uriu-Adams, Nutrition Department, University of California at Davis, Davis, California

4:00 pm å 4:15 pm

CASPASE-3-INDUCED AUGMENTATION OF THE INTRINSIC, MITOCHONDRIAL APOPTOTIC PATHWAY
S.A. Little and P.E. Mirkes, University of Washington, Seattle, Washington

4:15 pm å 4:30 pm

TERATOGEN-INDUCED ACTIVATION OF CASPASE-6 AND CASPASE-7 IN DAY 9 MOUSE EMBRYOS
S.A. Little and P.E. Mirkes, University of Washington, Seattle, Washington

4:30 pm å 4:45 pm

ARSENIC-INDUCED NEURAL TUBE DEFECTS IN A C57BL/6J SPLOTCH HETEROZYGOTE CROSS
L.J. Martin, M.A. Loza, A.F. Machado, and M.D. Collins, UCLA, Los Angeles, California

2:00 pm å 2:15 pm

REPORT OF FIRST POSITIVE FINDINGS FROM HOSPITAL-BASED AED PREGNANCY REGISTRY
L.B. Holmes and E. Lieberman, For the Scientific Advisory Committee of the AED (antiepileptic drug) Pregnancy Registry, Genetics and Teratology Unit, Pediatric Service, Massachusetts General Hospital, Boston, Massachusetts

2:15 pm å 2:30 pm

GENOTYPE AND GENE TRANSMISSION IN FAMILIES WITH EITHER AUTISM SPECTRUM DISORDERS (ASDS) OR JUVENILE DIABETES (JD)
C. Stodgell, L .Weitkamp, S. Hyman, H. Fong, M. OÁBara, and P. Rodier, University of Rochester, Rochester, New York

2:30 pm å 2:45 pm

EXCESS VARIANCE OF SUBCORTICAL BRAIN SHAPE IN FETAL ALCOHOL SPECTRUM DISORDERS: AN ANALYSIS BY LANDMARK LOCATION DATA
F.L. Bookstein¹, P.D. Sampson², P.D. Connor², and A.P. Streissguth². ¹University of Michigan, Ann Arbor, Michigan; ²University of Washington, Seattle, Washington

2:45 pm å 3:00 pm

MORPHOMETRIC DIAGNOSIS OF FETAL ALCOHOL SPECTRUM DISORDERS BY CALLOSAL SHAPE
F.L. Bookstein¹, P.D. Sampson², P.D. Connor², and A.P. Streissguth². ¹University of Michigan, Ann Arbor, Michigan; ²University of Washington, Seattle, Washington

3:00 pm å 3:15 pm

IN UTERO HIV-1 INFECTION: ROLE OF PLACENTAL INFECTION
R.K. Miller¹, B.M. Polliotti¹, T.S. Laughlin¹, and M. Carneiro². ¹Obs/Gyn, University of Rochester, Rochester, New York; ²Maternidad Conception Palacios, Caracas, Venezuela

3:15 pm å 3:30 pm

BREAK

3:30 pm å 3:45 pm

EFFECT OF PERICONCEPTIONAL FOLIC ACID ON PHENOTYPES OF NEURAL TUBE DEFECTS SINO-U.S. NTD PREVENTION PROJECT
C.A. Moore¹, Z. Li², R.J. Berry¹, S. Li², J.D. Erickson¹, S.X. Hong², and A. Correa¹. ¹Birth Defects and Genetic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia; ²National Center for Maternal and Infant Health, Peking University, Beijing, China

3:45 pm å 4:00 pm

COLD SORES AND OROFACIAL CLEFTS
P.A. Romitti, J.C. Murray, S. Daack-Hirsch and T.L. Burns, University of Iowa, Iowa City, Iowa

4:00 pm å 4:15 pm

RISING TREND IN GASTROSCHISIS AMONG YOUNGER MOTHERS IN AUSTRALIA
P.A.L. Lancaster and T. Hurst, AIHW National Perinatal Statistics Unit, Sydney ChildrenÁs Hospital and The University of New South Wales, Sydney, Australia

4:15 pm å 4:30 pm

NON-SYNDROMIC OROFACIAL CLEFTS AMONG THE OFFSPRING OF WOMEN WHO CONSUMED FOLIC ACID DURING EARLY PREGNANCY SINO-U.S. NTD PREVENTION PROJECT
Z. Li¹, R.J. Berry², S. Li¹, C.A. Moore², S.X. Hong¹, L.Y. Wong², and J. Gindler². ¹National Center for Maternal and Infant Health, Peking University, Beijing, China; ²Birth Defects and Genetic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia

4:30 pm å 4:45 pm

PREVENTION OF BIRTH DEFECTS AMONG WOMEN WHO CONSUMED FOLIC ACID SUPPLEMENTS DURING EARLY PREGNANCY SINO-U.S. NTD PREVENTION PROJECT
M.F. Myers¹, Z. Li², A. Correa¹, S. Li², R.J. Berry¹, S.X. Hong², C.A. Moore¹, H. Wong², and D.J. Erickson¹. ¹Birth Defects and Genetic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia; ²National Center for Maternal and Infant Health, Peking University, Beijing, China

9:00 Am å 9:45 Am

DOSE-RESPONSE RELATIONSHIPS
Speaker: Tom Shepard, Central Lab for Human Embryology, Department of Pediatrics, University of Washington, Seattle, Washington

9:45 am å 10:30 am

MONITORING LEFLUNOMIDE (ARAVA®) AS A NEW POTENTIAL TERATOGEN
Speaker: Ken Jones, Department of Pediatrics, University of California at San Diego Medical Center, San Diego, California

11:00 AM å 11:45 AM

PROBLEMS WITH INFORMING WOMEN ADEQUATELY ABOUT TERATOGENIC RISKS OF ISOTRETINOIN (ACCUTANE®)
Speaker: Peggy Honein, Birth Defects & Pediatric Genetics Branch, Centers for Disease Control, Atlanta, Georgia

11:45 AM å 12:30 PM

NEW CANDIDATES FOR THE LIST OF HUMAN TERATOGENS
Speaker: Lew Holmes, Genetics & Teratology Unit, Massachusetts General Hospital, Boston, Massachusetts

9:00 AM å 9:10 AM

INTRODUCTION
Craig Harris

9:10 AM å 10:30 AM

CELLULAR THIOLS AND REDOX-REGULATED SIGNAL TRANSCRIPTION
Speaker: Chandan K. Sen, The Ohio State University Medical Center, Columbus, Ohio

11:00 AM å 11:45 AM

REDOX REGULATION OF LIMB OUTGROWTH IN THALIDOMIDE TERATOGENICITY
Speaker: Craig Harris, Toxicology Program, University of Michigan, Ann Arbor, Michigan

11:45 AM å 12:30 PM

REACTIVE OXYGEN SPECIES AND OXIDATIVE DAMAGE IN CHEMICAL TERATOGENESIS
Speaker: Peter Wells, University of Toronto, Toronto, Ontario

9:00 AM å 9:30 AM

IMMUNOLOGY AT THE MATERNAL-FETAL INTERFACE LESSONS FOR T-CELL TOLERANCE
Speaker: Andrew Mellor, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia

9:30 AM å 10:00 AM

ADVERSE PREGNANCY OUTCOME IN NON-HUMAN PRIMATES EXPOSED TO LISTERIA MONOCYTOGENES A MODEL FOR HUMANS
Speaker: Mary Alice Smith, University of Georgia, Athens, Georgia

10:00 AM å 10:30 AM

SALMONELLA SEPSIS AND SECOND-TRIMESTER PREGNANCY LOSS
Speaker: Tony Scialli, Department of Obstetrics & Gynecology, Georgetown University Medical Center, Washington, D.C.

11:00 AM å 11:30 AM

TOXOPLASMOSIS DURING PREGNANCY A SILENT KILLER
Speaker: Jose Montoya, Department of Medicine, Stanford University School of Medicine, Stanford, California

11:30 AM å 12:00 pM

EVOLVING WITH OUR FOOD AN EVOLUTIONARY PERSPECTIVE ON MORNING SICKNESS
Speaker: Samuel Flaxman, Department of Neurobiology and Behavior, Cornell University, Ithaca, New York

12:00 PM å 12:30 pM

FOOD SAFETY ISSUES DURING PREGNANCY
Speaker: Eileen Parish, Center for Food Safety and Applied Nutrition, USFDA, Washington, D.C.

2:00 PM å 2:15 PM

TERATOGENIC RESPONSES OF TGF KNOCKOUT FETUSES TO 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD)
B.D. Abbott¹, A.R. Buckalew¹, and P.L. Bryant². ¹Reproductive Toxicology Division, EPA, Research Triangle Park, North Carolina; ²Dept. Environ. Sciences & Engineering, UNC, Chapel Hill, North Carolina

2:15 PM å 2:30 PM

EXPRESSION OF TGF AND ECM PROTEINS IN EMBRYONIC MOUSE HEARTS EXPOSED TO HYPERGLYCEMIA IN VIVO AND IN VITRO
R.L. Leonard, D.J. Williams, and I.W. Smoak, Department of Anatomy, Physiological Sciences, & Radiology, College of Veterinary Medicine, NCSU, Raleigh, North Carolina

2:30 PM å 2:45 PM

EFFECTS OF LOW AND HIGH DOSE BISPHENOL A AND 17-ESTRADIOL PRENATAL EXPOSURE ON ESTROGEN RECEPTORS
G. Schoenfelder, B. Flick, L. Mayr, C. Talsness, M. Paul and I. Chahoud, Inst. of Clinical Pharmacology and Toxicology, Benjamin Franklin Medical Center, FU Berlin, Germany

2:45 PM å 3:00 PM

MANDIBULAR REPATTERNING RESULTS FROM IN UTERO ANTAGONISM OF ENDOTHELIN RECEPTORS IN MICE
K.C. Brannen^1,2, E.S. Hunter^1,2, M.B. Rosen², and J.M. Rogers^1,2. ¹Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; ²Reproductive Toxicology Division, NHEERL, USEPA, Research Triangle Park, North Carolina

3:00 PM å 3:15 PM

HALOACETIC ACIDS AND KINASE INHIBITORS PERTURB MOUSE NEURAL CREST CELLS IN VITRO
E.S. Hunter¹, J. Smith², J. Andrews¹. ¹Reproductive Toxicology Division, NHEERL, USEPA, Research Triangle Park, North Carolina; ²Department of Cell and Developmental Biology, UNC-CH, Chapel Hill, North Carolina

3:15 PM å 3:30 PM

BREAK

3:30 PM å 3:45 PM

ROLE OF TOTAL RADICAL ANTIOXIDANT POTENTIAL IN VALPROATE INDUCED CONGENITAL MALFORMATIONS
M. Tariq, Arshaduddin, M., K. Al Moutaery and S. Al Deeb, Armed Forces Hospital, Riyadh, Saudi Arabia

3:45 PM å 4:00 PM

ADHD ASSESSMENT OF NEONATAL THYROXINE AS A BIOMARKER
S.H. Lamm^1,5, A. Nandedkar², K. Japal², S. Mosee², M. Stein³, P. Magrab⁴, S. Lai^1,5, S. Chang^1,5, and O.P. Soldin¹. ¹Consultants in Epidemiology and Occupational Health, Inc., Washington, DC; ²Howard University, Washington, DC; ³ChildrenÁs National Medical Center, Washington, DC; ⁴Georgetown University; Washington, DC; and ⁵Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland

4:00 PM å 4:15 PM

ADVERSE PRE- AND POSTNATAL EVENTS REPORTED TO FDA IN ASSOCIATION WITH MATERNAL ATENOLOL TREATMENT IN PREGNANCY
S. Tabacova¹, C.A. McCloskey² and C.A. Kimmel³. ¹National Center for Toxicological Research, FDA Rockville, Maryland; ²Center for Drug Evaluation and Research, FDA, Rockville, Maryland; and ³National Center for Environmental Assessment, USEPA, Washington, D.C.

4:15 PM å 4:30 PM

EFFECT OF IN UTERO EXPOSURE OF DIOXIN ON DEVELOPMENT OF YOUNG IN RHESUS MONKEYS
M. Yasuda¹, K. Yamashita¹, K.A. Matsui¹, T. Ihara², A. Oneda², M. Inouye², R. Nagata², T. Takasuga³, and S. Kubota⁴. ¹Hiroshima University School of Medicine, Hiroshima; ²Shin Nippon Biomedical Laboratories, Ltd., Kagoshima; ³Shimadzu-Techno-Research Inc., Kyoto; and ⁴Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

4:30 PM å 4:45 PM

CRANIOFACIAL MALFORMATIONS OBSERVED IN F1 PUPS OF SPRAGUE-DAWLEY (SD) RATS ADMINISTERED PROPYLTHIOURACIL (PTU) IN DRINKING WATER
L. Nehrebeckyj¹, Y. Wang¹, J. Quance² , J. Kariya³, G.W. Wolfe¹, and J. Bishop⁴. ¹TherImmune Research Corporation, Gaithersburg, Maryland; ²PAI, Frederick, Maryland; ³USEPA, Washington, DC; ⁴NIEHS/NTP, Research Triangle Park, North Carolina

2:00 PM å 2:15 PM

RISK OF MALFORMATION AND DEVELOPMENTAL DELAY IN A COHORT OF CHILDREN AND ADULTS EXPOSED TO ANTIEPILEPTIC DRUGS IN UTERO
J.C.S. Dean¹, S.J. Moore², P.D. Turnpenny³, H. Hailey¹, and D.J. Lloyd¹. ¹Department of Medical Genetics, University of Aberdeen, Scotland; ²Newfoundland and Labrador Medical Genetics Program, Memorial University of Newfoundland, St Johns, Newfoundland; 3Clinical Genetics Service, Royal Devon and Exeter Hospital, Exeter, England

2:15 PM å 2:30 PM

STUDY OF PLACENTA OF CHILDREN BORN WITH CONGENITAL MALFORMATIONS
C. Stoll, Y. Alembik, B. Dott, and M.P. Roth, Génétique Médicale, Centre Hospitalo-Universitaire, Strasbourg, France

2:30 PM å 2:45 PM

A PROSPECTIVE STUDY OF ALCOHOL EXPOSURE DURING PREGNANCY: CORRELATION OF QUANTITY WITH FREQUENCY OF FEATURES CHARACTERISTIC OF FAS
C.D. Chambers, L. M. Dick, R.J. Felix, K.A. Johnson and K.L. Jones, UCSD, La Jolla, California

2:45 PM å 3:00 PM

ABSENCE OR REDUCTION OF SPECIFIC ARTERIES ASSOCIATED WITH CONGENITAL VERTICAL TALUS AND CLUBFOOT DEFORMITIES
D.R. Hootnick^1,2,3, D.S. Packard, Jr.¹, and E.M. Levinson⁴. ¹Department of Cell and Developmental Biology, ²Department of Pediatrics, ³Department of Orthopedic Surgery, Upstate Medical University, Syracuse, New York; ⁴Department of Medical Imaging, Crouse Hospital, Syracuse, New York

3:00 PM å 3:15 PM

THE LONGITUDINAL COHORT STUDY OF ENVIRONMENTAL EFFECTS ON CHILD HEALTH AND DEVELOPMENT
C.A. Kimmel for the Longitudinal Cohort Study (LCS) Interagency Coordinating Committee. National Center for Environmental Assessment, U.S. Environmental Protection Agency, Washington, DC.

3:15 PM å 3:30 PM

BREAK

3:30 PM å 3:45 PM

DOSE RESPONSE TO DICLECTIN® IN HUMAN PREGNANCIES
G. Atanackovic¹, Y. Navoiz², M. Moretti² and G. Koren². ¹Duchesnay Inc., Laval, Canada; ²The Motherisk Program, The Hospital for Sick Children, Toronto, Canada

3:45 PM å 4:00 PM

PREGNANCY OUTCOME FOLLOWING GESTATIONAL EXPOSURE TO LORATADINE AND OTHER ANTIHISTAMINES: A PROSPECTIVE CONTROLLED COHORT STUDY
O. Diav-Citrin¹, S. Shechtman⁰, L. Moerman¹, J. Arnon¹, R. Wajnberg¹ and A. Ornoy^1,2. ¹The Israeli Teratogen Information Service, Israel Ministry of Health; and the ²Hebrew University Hadassah Medical School, Jerusalem, Israel

4:00 PM å 4:15 PM

MÖBIUS SYNDROME/SEQUENCE: A SUMMARY OF A BRAZIL STUDY
M.T. Miller¹ and L. Ventura². ¹Department of Ophthalmology, University of Illinois at Chicago, Chicago, Illinois; and ²Hospital de Olhos de Pernambuco, Fundação Altino Ventura, Recife, Brazil

4:15 PM å 4:30 PM

SOCIOECONOMIC STATUS AS A RISK FACTOR FOR THE BIRTH OF AN INFANT WITH DOWN SYNDROME (DS), ACCORDING TO THE MEIOTIC STAGE OF MATERNAL ORIGIN
C.P. Torfs and R.E. Christianson, Public Health Institute, Berkeley, California

4:30 PM å 4:45 PM

MATERNAL SUBFERTILITY AND CONGENITAL RENAL ANOMALIES
M.A. Honein and C.A. Moore, Birth Defects and Pediatric Genetics Branch, Centers for Disease Control and Prevention, Atlanta, Georgia

2:00 PM å 2:15 PM

MICROTIA AND HEARING DEFICITS IN CD-1 MICE FOLLOWING GESTATIONAL EXPOSURE TO ETHANE DIMETHANESULFONATE (EDS)
D.K. Tarka^1,2, G.R. Klinefelter^1,2, D.W. Herr³, and J.M. Rogers^1,2. ¹University of North Carolina, School of Medicine, Curriculum in Toxicology, Chapel Hill, North Carolina; and USEPA, NHEERL, ²Reproductive Toxicology Division and ³Neurotoxicology Division, Research Triangle Park, North Carolina

2:15 PM å 2:30 PM

BIRTH WEIGHT IS NOT AFFECTED BY THE PRESENCE OF A SINGLE OR MULTIPLE NUCHAL CORD ENCIRCLEMENTS
J.C. Carey and W.F. Rayburn, Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

2:30 PM å 2:45 PM

EFFECT OF A COX-2 INHIBITOR, ROFECOXIB, ON CLOSURE OF THE FETAL RAT DUCTUS ARTERIOUS
L.D. Wise, M.A. Cukierski, L.A. Shelly and D.H. Patrick, Merck Research Laboratories, West Point, Pennsylvania

2:45 PM å 3:00 PM

DOSE-RATE IS A CRITICAL DETERMINANT OF ETHYLENE GLYCOL DEVELOPMENTAL TOXICITY IN RATS
E.W. Carney, A.B. Liberacki, B. Tornesi and D.A. Markham, The Dow Chemical Company, Midland, Michigan

3:00 PM å 3:15 PM

SKELETON CHANGES IN DIFFERENT CARTILAGE AND BONE STAINING IN FETUSES EXPOSED TO PROPYPHENAZONE
F. Burdan, Experimental Teratology Unit of Human Anatomy Department, Medical University School of Lublin, Poland

3:15 PM å 3:30 PM

BREAK

3:30 PM å 3:45 PM

IN-UTERO PROPYPHENAZONE EXPOSURE AFFECTS AN INCREASE OF THE ACTIVITY OF THE FETAL LIVER LYSOSOMAL CATHEPSIN B, D AND L
F. Burdan, T. Blicharski, R. Klepacz and A. Sek, Experimental Teratology Unit of Human Anatomy Department, Medical University School of Lublin, Poland

3:45 PM å 4:00 PM

A STUDY OF HYPERICIN-INDUCED TERATOGENICITY DURING ORGANOGENESIS USING A WHOLE RAT EMBRYO CULTURE MODEL
L.Y. Chan, P.Y. Chiu and T.K. Lau, Department of Obstetrics and Gynecology, The Chinese University of Hong Kong, Hong Kong

4:00 PM å 4:15 PM

MORPHINE- INDUCED CENTRAL NERVOUS SYSTEM DEFECTS IN MICE
A.R. Fazel and M. Jalali, Dept. of Anatomy, Mashhad University of Medical Sciences, Mashhad, Iran

4:15 PM å 4:30 PM

OCULOTERATOGENIC AND RELATED EFFECTS OF OPIOID DRUG DURING EMBRYONIC DEVELOPMENT IN MICE
A.R. Fazel and M. Jalali, Dept. of Anatomy, Mashhad University of Medical Sciences, Mashhad, Iran

4:30 PM å 4:45 PM

ORAL EXPOSURE IN DERMAL STUDIES: A CONFOUNDING FACTOR IN DRUG SAFETY EVALUATION
G. Millicovsky, S. Sista, and K. Albert. Biovail Technologies, Ltd., Chantilly, Virginia

9:00 AM å 9:10 AM

Introduction Richard Finnell

9:10 AM å 9:50 AM

MTHFR MUTATIONS AND BIRTH DEFECTS IN MICE
Speaker: Rima Rozen, McGill University, Montréal, Québec

9:50 AM å 10:30 AM

A GENOMIC RESOURCE OF MOUSE MUTATIONS IN CELL SURFACE PROTEINS
Speaker: Bill Skarnes, University of California at Berkeley, Berkeley, California

10:30 AM å 10:45 AM

BREAK

10:45 AM å 11:25 AM

ANALYSIS OF A GENETIC MODEL FOR DIABETIC EMBRYOPATHY IN THE MOUSE
Speaker: Claudia Kappen, University of Nebraska Medical Center, Omaha, Nebraska

11:25 AM å 12:00 PM

MOUSE MODELS OF FOLATE TRANSPORT DEFICIENCIES AND THEIR RELATIONSHIP TO COMPLEX CONGENITAL ANOMALIES
Speaker: Richard Finnell, University of Nebraska Medical Center, Omaha, Nebraska

9:00 AM å 9:45 AM

PRECLINICAL REPRODUCTIVE TOXICOLOGY "THE WEDGE"
Speaker: David Morse, Center for Drug Evaluation and Research, USFDA, Rockville, Maryland

9:45 AM å 10:30 AM

POST-MARKETING SURVEILLANCE: AN UPDATE ON PREGNANCY REGISTRIES
Speaker: Evelyn Rodriguez, Center for Drug Evaluation and Research, USFDA, Rockville, Maryland

10:30 AM å 10:45 AM

BREAK

10:45 AM å 11:20 AM

PROGRESS REPORT ON THE PREGNANCY LABELING REVISION
Speaker: Sandra Kweder, Center for Drug Evaluation and Research, USFDA, Rockville, Maryland

11:20 AM å 12:00 PM

MONITORING THE EFFECTIVENESS OF PREGNANCY PREVENTION PROGRAMS FOR KNOWN TERATOGENS
Speaker: Tony Scialli, Department of Obstetrics & Gynecology, Georgetown University Medical Center, Washington, D.C.