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2001 ANNUAL MEETING
Tentative Schedule

MONTREAL, QUEBEC

February 2001


Revised 2/9/01

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SATURDAY, 23 JUNE, 13:30-17:30 and
SUNDAY, 24 JUNE,
08:30-12:30

EDUCATION COURSE: Principles of Teratology: Application of New Technologies Towards Understanding Abnormal Development
[Organized by Kok-Wah Hew and the Education Committee]

James Schardein: Review of the principles of teratology
Tom Knudsen: Technologies to analyze teratogenic mechanisms
Simon Ward: Gene-teratogen interaction ú genotype-related susceptibility during development
Phil Mirkes: Apoptosis ú cell-specific susceptibility during development
Bruce Carlson: Limb development ú tissue-specific susceptibility during development
John Rogers: Spatiotemporal patterns of gene expression ú developmental stage-related susceptibility
Peter Wells: Reactive intermediates and abnormal development ú agent-specific susceptibility
Elaine Faustman: Dose-dependent susceptibility
Bill Scott: Current knowledge of abnormal development ú an overview


SUNDAY, 24 JUNE
14:00-17:00

MARCH OF DIMES SYMPOSIUM: Male-Mediated Developmental Toxicity
[Organized by Barbara Hales, Andy Olshan, and Donald Mattison]

Barbara Hales: Introduction
Andy Olshan: The human story ú where are we now?
Sally Perreault Darney: Detecting adverse effects on the paternal genome
Andy Wyrobek: Effects on progeny outcome ú human and animal studies to elucidate mechanisms
Bernard Robaire: Are there appropriate biomarkers of paternal drug exposure that predict altered progeny outcome?
Donald Mattison: Closing remarks

17:00-19:30 EXHIBITS OPEN
17:00-18:00 ISSUES FORUM: Redesign and relaunch of the Societyçs journal
18:00-19:30 PRESIDENTçS RECEPTION

MONDAY, 25 JUNE
08:30-09:30 THE JOSEF WARKANY LECTURE
Philip E. Mirkes: To die, or not to die: that is the question
09:30-12:30

WILEY-LISS SYMPOSIUM: Pluripotent Stem Cells In and Out Of The Embryo
[Organized by Tom Knudsen]

Peter Donovan:Overview of the biology of pluripotent stem cells
John Gearhart: Derivation and therapeutic potential of embryonic stem cells in human diseases
Horscht Spielmann: Application of embryonic stem cells as research tools to address fundamental processes in developmental toxicity
Laurie Zoloth: Issues in the bioethics of pluripotent stem cells

12:30-19:30 POSTERS AND EXHIBITS OPEN
14:00-14:45 THE JAMES G. WILSON PUBLICATION AWARD
14:45-17:00 STUDENT PLENARY SESSION
17:00-19:30 POSTER SESSION I
19:30-22:30 MARTA/MTA Student Reception


TUESDAY, 26 JUNE

09:00-12:30

NBTS/TERATOLOGY SOCIETY JOINT SYMPOSIUM: Genetic Pathways of Neurodevelopment
[Organized by Patty Rodier and Merle Paule]

ä David Skuse: Turner syndrome
ä
Maureen Dennis: Neural tube defects
ä
Bernard Maria: Joubert syndrome
ä
Anne S. Bassett: Velo-cardio-facial syndrome

09:30-12:30

OTIS/TERATOLOGY SOCIETY JOINT SYMPOSIUM: Teratology of Obstetrical Procedures
[Organized by Karen Filkins]

Ron Wapner, Lew Holmes, Karen Filkins: Chorionic villus sampling
Doug Wilson: Early amniocentesis
R.L. Berkowitz: Percutaneous umbilical artery sampling (PUBS)
R.L. Berkowitz, Ron Wapner: Reproductive technologies and fetal reduction procedures
Karin Blakemore: Fetal stem cell therapy and other medical therapies
Karin Blakemore, T.M. Goodwin: Delivery complications

12:30-19:30 POSTERS AND EXHIBITS OPEN
14:00-17:00 PLATFORM SESSION 1
14:00-17:00 PLATFORM SESSION 2
17:00-19:30 POSTER SESSION II

WEDNESDAY, 27 JUNE
09:00-12:30

WORKSHOP: Teratogen Update
[Organized by Lew Holmes]

Tom Shepard: Dose-response relationships
Ken Jones: Monitoring leflunomide (Arava ® ) as a new potential teratogen
Peggy Honein: Problems with informing women adequately about teratogenic risks of isotretinoin (Accutane ® )
Lew Holmes: New candidates for the list of human teratogens

09:00-12:30

WORKSHOP: Redox Regulation in Mechanisms of Teratogenesis
[Organized by Craig Harris]

Chandan K. Sen: Cellular thiols and redox-regulated signal transcription
Craig Harris: Redox regulation of limb outgrowth in thalidomide teratogenicity
Peter Wells: Reactive oxygen species and oxidative damage in chemical teratogenesis

09:00-12:30

WORKSHOP: Foodborne Infections During Pregnancy
[Organized by Tom Flynn]

Andrew Mellor: Immunology at the maternal-fetal interface ú lessons for T-cell tolerance
Mary Alice Smith: Adverse pregnancy outcome in non-human primates exposed to Listeria monocytogenes ú a model for humans
Tony Scialli: Salmonella sepsis and second-trimester pregnancy loss
Jose Montoya: Toxoplasmosis during pregnancy ú a silent killer
Samuel Flaxman: Evolving with our food - an evolutionary perspective on morning sickness
Eileen Parish: Food safety issues during pregnancy

14:00-17:00 PLATFORM SESSION 3
14:00-17:00 PLATFORM SESSION 4
14:00-17:00 PLATFORM SESSION 5 - (Joint with OTIS)
17:00-18:00 BUSINESS MEETING
19:00-20:00 RECEPTION
20:00- BANQUET

THURSDAY, 28 JUNE
09:00-12:00

GENOME SYMPOSIUM: Using Genomics to Study Birth Defects
[Organized by Richard Finnell]

Rima Rozen: MTHFR mutations and birth defects in mice
Bill Skarnes: A genomic resource of mouse mutations in cell surface proteins
Claudia Kappen: Analysis of a genetic model for diabetic embryopathy in the mouse
Richard Finnell: Mouse models of folate transport deficiencies and their relationship to complex congenital anomalies

09:00-12:00

PUBLIC AFFAIRS SYMPOSIUM: A Report Card on FDAçs Efforts to Prevent Teratogenic Birth Defects
[Organized by Tina Chambers and Tom Collins]

Joseph DiGeorge: Preclinical reproductive toxicology --"the Wedge"
Evelyn Rodriguez: Update on post-marketing surveillance
Sandra Kweder: Progress report on the pregnancy labeling revision
Tony Scialli: Monitoring the effectiveness of pregnancy prevention programs for known teratogens

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rev. 10-Jun-2003

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