Saturday, June 24
11:00 am – 5:00 pm	Registration
12:00 pm – 6:00 pm	Council IA Meeting
1:00 pm – 5:15 pm	Education Course: Signal Transduction: Pathways to Growth, Differentiation, and Morphogenesis
Sunday, June 25 top
7:30 am – 5:00 pm	Registration
7:00 am – 2:00 pm	Council IB Meeting
8:15 am – 12:00 noon	Education Course (Continued from Saturday)
1:30 pm – 5:00 pm	March of Dimes Symposium: Genetic Susceptibility to Teratogenesis Chairpersons: Mike Collins and Michael Katz Supported in part by March of Dimes Birth Defects Foundation Grant No.4-FY96-8960
1:30 – 1:40 pm	INTRODUCTION M.D. Collins, UCLA, Los Angeles, California and M. Katz, March of Dimes, White Plains, New York
1:40 – 2:20 pm	GENE-ENVIRONMENT INTERACTIONS IN BIRTH DEFECTS J.C. Murray, The University of Iowa, Department of Pediatrics, Iowa City, Iowa
2:20 – 2:50 pm	WHOLE GENOME SCAN TO IDENTIFY CHROMOSOMAL LOCI ASSOCIATED WITH A STRAIN DIFFERENCE IN SUSCEPTIBILITY TO CADMIUM-INDUCED FORELIMB DEFECTS M.D. Collins, UCLA, Los Angeles, California
2:50 – 3:05 pm	BREAK
3:05 – 3:35 pm	INSIGHTS FROM GENOME SCANS VERSUS CANDIDATE GENE POLYMORPHISMS FOR UNDERSTANDING THE ETIOLOGY OF TERATOGEN-INDUCED ORAL CLEFTS IN MOUSE AND MAN S.R. Diehl, Craniofacial Epidemiology and Genetics Branch, NIDCR, NIH, Bethesda, Maryland
3:35 – 4:05 pm	INTERPRETATION OF TERATOGENETICS D.M. Juriloff, Department of Medical Genetics, University of British Columbia, Vancouver, B.C., Canada
4:05 – 5:00 pm	HOLOPROSENCEPHALY AS A MODEL TO UNDERSTAND BRAIN DEVELOPMENT M. Muenke, Medical Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, and The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
6:00 pm – 7:30 pm	President's Reception (Sponsored by Elsevier)
6:00 pm – 7:30 pm	Exhibits Open
Monday, June 26 top
7:00 am – 7:45 am	Continental Breakfast
7:30 am – 5:00 pm	Registration
7:45 am – 8:00 am	President's Welcome and Introduction George P. Daston
8:00 am – 8:45 am	Warkany Lecture Alteration of Pattern Formation as a Mechanism of Teratogenesis William J. Scott, Jr., University of Cincinnati
Monday 9:00 am – 12:10 pm	Wiley-Liss Symposium Angiogenesis Chairpersons: William Slikker, Jr. and Karen Augustine Sponsored by John Wiley & Sons, Inc.
9:00 – 9:10 am	OVERVIEW K.A. Augustine and W. Slikker
9:10 – 9:50 am	ENDOTHELIAL CELL ORIGINS AND BLOOD VESSEL MORPHOGENESIS T.J. Poole, Department of Cell and Developmental Biology, Upstate Medical University, Syracuse, New York
9:50 – 10:30 am	REGULATION OF VASCULOGENESIS AND ANGIOGENESIS B.D. Abbott, Reproductive Toxicology Division, USEPA, Research Triangle Park, North Carolina
10:30 – 10:45 am	BREAK
10:45 – 11:25 am	MOLECULAR DETERMINANTS OF VASCULOGENIC MIMICRY BY AGGRESSIVE TUMOR CELLS: NEW THERAPEUTIC TARGETS FOR CLINICAL INTERVENTION M.J.C. Hendrix, The University of Iowa Cancer Center, Iowa City, Iowa
11:25 am–12:10 pm	ANTI-ANGIOGENIC THERAPIES INCLUDING THALIDOMIDE D.I. Stirling, Celgene Corporation, Warren, New Jersey
Monday 12:00 – 1:00 pm	Past Presidents' Luncheon Sponsored by Proctor & Gamble Company (By Invitation Only)
1:00 pm – 1:45 pm	James G. Wilson Publication Award
Monday 1:45 pm – 3:15 pm	Platform Ia: Student Plenary Session 1 Chairpersons: Kit Keller and Craig Harris
1:45 – 2:00 pm	EFFECTS OF SERA FROM WOMEN WITH SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) AND RECURRENT ABORTIONS ON HUMAN PLACENTAL EXPLANTS IN CULTURE S. Yacobi, A. Ornoy, and R.K. Miller, Hebrew University Hadassah Medical School, Jerusalem, Israel; University of Rochester, Rochester, New York
2:00 – 2:15 pm	HIV-1 INFECTION IN EARLY HUMAN PLACENTAE IN VITRO: EFFECTS OF TUMOR NECROSIS FACTOR (TNFa) AND INTERLEUKINS (IL-1 & IL-6) Y. Ding, T. Laughlin, B.M. Polliotti, and R.K. Miller, University of Rochester, Rochester, New York
2:15 – 2:30 pm	CASPASE-3 ENZYME ACTIVITY AS A MARKER FOR TERATOGEN-INDUCED APOPTOSIS IN DAY 9 MOUSE EMBRYOS AND ASSOCIATED YOLK SACS: EVIDENCE FOR YOLK SAC RESISTANCE TO TERATOGEN-INDUCED APOPTOSIS D. Soleman and P.E. Mirkes, Department of Pediatrics, University of Washington, Seattle, Washington
2:30 – 2:45 pm	LASER CAPTURE MICRODISSECTION TO EXPLORE A POTENTIAL RELATIONSHIP BETWEEN DIFFERENTIAL GENE EXPRESSION AND ETHANOL-INDUCED APOPTOSIS W.C. Dunty, Jr., P.S. Stockton, R.C. Barber, R.H. Finnell, M. Miles, S.-Y. Chen, D.B. Dehart, and K.K. Sulik, Dept. of Cell Biology and Anatomy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Laboratory of Experimental Pathology, NIEHS, Research Triangle Park, North Carolina; Center for Human Molecular Genetics, University of Nebraska Medical Center, Omaha, Nebraska; and Dept. of Neurology, Ernest Gallo Clinic and Research Center, University of California, San Francisco, California
2:45 – 3:00 pm	EFFECT OF DEVELOPMENTAL EXPOSURE TO ETHANEDIMETHANE SULPHONATE (EDS), BROMOCHLOROACETIC ACID (BCA) AND MOLINATE ON WHOLE BODY TESTOSTERONE LEVELS IN CD-1 MICE D.K. Tarka, G.R. Klinefelter, J. Suarez, and J.M. Rogers, University of North Carolina, School of Medicine, Curriculum in Toxicology, Chapel Hill, North Carolina; USEPA, NHEERL, Reproductive Toxicology Division, Research Triangle Park, North Carolina
3:00 – 3:15 pm	DIABETIC EMBRYOPATHY: IMPACT OF THE SPLOTCH ALLELE A.F. Machado, E.F. Zimmerman, D.H. Hovland Jr., R. Weiss, and M.D. Collins, UCLA, Los Angeles, California; Children's Hospital Research Found., Cincinnati, Ohio
Monday 3:15 pm–4:30 pm	Platform Ib: Student Plenary Session 2 Chairpersons: Janet Uriu-Adams and Jack Bishop
3:15 – 3:30 pm	ENDOTHELIN-A RECEPTOR ANTAGONISM IN EMBRYO CULTURE: WINDOW OF SENSITIVITY AND TIMING OF DEFECT K.C. Brannen, J.M. Rogers, and E.S. Hunter, Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina, and Reproductive Toxicology Division, NHEERL, USEPA, Research Triangle Park, North Carolina
3:30 – 3:45 pm	DIFFERENTIAL EXPRESSION OF CELL CHECKPOINT REGULATOR/DNA DAMAGE SENSOR GENES DURING RAT EMBRYO ORGANOGENESIS IN VIVO AND IN VITRO R.K. Vinson and B. F. Hales, McGill University, MontrÃal, QC, Canada
3:45 – 4:00 pm	PK11195 INFLUENCES BIOGENESIS OF THE MOUSE mTDNA GENOME DURING NEURULATION R.J. Donahue, R.C. Craig, K.B. Knudsen, and T.B. Knudsen, Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, Philadelphia, Pennsylvania
4:00 – 4:15 pm	METHYLMERCURY TRANSIENTLY ALTERS MITOCHONDRIAL GENE EXPRESSION IN THE EMBRYO: EVIDENCE FOR DISRUPTION OF THE CELLULAR HEME PATHWAY M.F. O'Hara and T.B. Knudsen, Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, Philadelphia, Pennsylvania
4:15 – 4:30 pm	ANALYSIS OF MITOCHONDRIAL GENE EXPRESSION IN AN INTERVENTION MODEL FOR TERATOGENESIS J.H. Charlap, R.C. Craig, and T.B. Knudsen, Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, Philadelphia, Pennsylvania
4:00 pm – 10:00 pm	Exhibits Open
4:30 pm – 6:00 pm	Issues Forum
Monday 6:00 pm – 7:30 pm	Student Career Event Jointly sponsored by Aventis, MARTA, MTA, and Pfizer, Inc.
7:30 pm – 10:00 pm	Poster Session Sponsored by Covance Laboratories, Quintiles, SNBL, Springborn Laboratories, Inc., and TherImmune Research Corporation
Tuesday, June 27 top
7:30 am – 8:15 am	Continental Breakfast
7:00 am – 8:00 am	Exhibitor's Breakfast (By Invitation Only)
7:30 am – 5:00 pm	Registration
8:30 am – 11:45 am	NBTS/OTIS/Teratology Society Symposium Folate Supplementation and Birth Defects Chairpersons: Deborah Hansen and Elizabeth Yetley
8:30 – 8:35 am	INTRODUCTION D.K Hansen, National Center for Toxicological Research, Jefferson, Arkansas
8:35 – 9:10 am	POTENTIAL MECHANISM(S) FOR FOLATE PREVENTION OF NEURAL TUBE DEFECTS D.K Hansen, National Center for Toxicological Research, Jefferson, Arkansas
9:10 – 9:45 am	SUPPLEMENTATION WITH METHYL GROUP DONORS, FOLATE OR CHOLINE, DURING LATE PREGNANCY IN RATS IMPROVES VISUOSPATIAL MEMORY PERFORMANCE OF THE OFFSPRING C.L. Williams, Department of Psychology: Experimental, Duke University, Durham, North Carolina
9:45 – 10:00 am	BREAK
10:00 – 10:35 am	NATIONAL FOLIC ACID FORTIFICATION: HOW WE GOT THERE AND NEXT STEPS E.A. Yetley, Center for Food Safety and Applied Nutrition, FDA, Washington, District of Columbia
10:35 – 11:10 am	PRE- AND POST-FORTIFICATION MONITORING OF FOLATE AND VITAMIN B12 STATUS P.F. Jacques, Jean Mayer-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts
11:10 – 11:45 am	MONITORING CHANGES IN NEURAL TUBE DEFECT RATES — PRE- AND POST-FORTIFICATION J.D. Erickson, Centers for Disease Control and Prevention, Atlanta, Georgia
Tuesday 8:30 am – 12:00 noon	Symposium Developmental Risks of Disinfectant By-Products Symposium Chairperson: E. Sidney Hunter
8:30 – 8:45 am	SYMPOSIUM OVERVIEW E.S. Hunter, Reproductive Toxicology Division, NHEERL, USEPA, Research Triangle Park, North Carolina
8:45 – 9:25 am	OCCURRENCE OF DISINFECTION BY-PRODUCTS IN DRINKING WATER: IMPLICATIONS FOR EPIDEMIOLOGY AND TOXICOLOGY STUDIES S.W. Krasner, Metropolitan Water District of Southern California, La Verne, California
9:25 – 10:00 am	REPRODUCTIVE AND DEVELOPMENTAL EFFECTS OF DISINFECTION BY-PRODUCTS IN DRINKING WATER J.S. Reif, Department of Environmental Health, Colorado State University, Ft. Collins, Colorado
10:00 – 10:15 am	BREAK
10:15 – 10:45 am	TRIHALOMETHANE-INDUCED PREGNANCY LOSS IN RATS M. Narotsky, Reproductive Toxicology Division, NHEERL, USEPA, Research Triangle Park, North Carolina
10:45 – 11:25 am	BIOMARKERS OF TRICHLOROETHYLENE EXPOSURE O. Selmin, Pediatric Cardiology, College of Medicine, University of Arizona Health Sciences Center, Tucson, Arizona
11:25 – 12:00 pm	IN VITRO AND IN VIVO REPRODUCTIVE AND DEVELOPMENTAL TOXICITY OF DRINKING WATER DISINFECTION BY-PRODUCTS R. Tyl, Center for Life Sciences and Toxicology, Research Triangle Institute, Research Triangle Park, North Carolina
Tuesday 1:00 pm – 2:30 pm	Platform IIa: Teratology Society/OTIS Joint Session 1 Chairpersons: Karen Filkins and Ashner Ornoy
1:00 – 1:15 pm	DO ANTIEPILEPTIC DRUGS COMBINED WITH CAFFEINE INCREASE THE RISK OF BIRTH DEFECTS? E.B. SamrÃn, C.M. van Duijn, G.C.M.L. Christiaens, A. Hofman, and D. Lindhout, Department of Clinical Genetics, University Hospital Rotterdam, Rotterdam, The Netherlands; Department of Epidemiology & Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands; MGC-Department of Clinical Genetics, Erasmus University Rotterdam, Rotterdam, The Netherlands; Department of Gynaecology and Obstetrics, University Medical Centre Utrecht, Utrecht, The Netherlands
1:15 – 1:30 pm	IS CARBAMAZEPINE ADMINISTRATION DURING PREGNANCY TERATOGENIC? A PROSPECTIVE CONTROLLED STUDY ON PREGNANCY OUTCOMES IN 229 EXPOSED WOMEN A. Ornoy, S. Shechtman, J. Arnon and O. Diav-Citrin, The Israeli Teratogen Information Service; the Hebrew University Hadassah Medical School; Israel Ministry of Health, Jerusalem, Israel.
1:30 – 1:45 pm	PREGNANCY OUTCOME FOLLOWING GESTATIONAL EXPOSURE TO METRONIDAZOLE: A PROSPECTIVE CONTROLLED COHORT STUDY O. Diav-Citrin, T. Gotteiner, S. Shechtman, J. Arnon, and A. Ornoy, The Israeli Teratogen Information Service, the Hebrew University Hadassah Medical School and Israel Ministry of Health, Jerusalem, Israel
1:45 – 2:00 pm	FETAL ABNORMALITIES ASSOCIATED WITH HIGH-DOSE TRANYLCYPROMINE IN TWO CONSECUTIVE PREGNANCIES D.S. Kennedy, N. Evans, I. Wang, and W.S. Webster, Royal Prince Alfred Hospital and The University of Sydney, Sydney, Australia
2:00 – 2:15 pm	MATERNAL ALCOHOL CONSUMPTION AND INTRAUTERINE GROWTH RETARDATION: A POPULATION-BASED CASE-CONTROL STUDY Q.H. Yang, B.B. Witkiewicz, R.S. Olney, Y.C. Liu, M. Davis, M.J. Khoury, A. Correa, and J.D. Erickson, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia and Monroe County Department of Health, Rochester, New York
2:15 – 2:30 pm	PROSPECTIVE PREGNANCY OUTCOME IN WOMEN EXPOSED TO AMPHETAMINES R.J. Felix, C.D. Chambers, L.M. Dick, K.A. Johnson, and K.L. Jones, Department of Pediatrics, Division of Dysmorphology and Teratology, University of California San Diego, La Jolla, California
Tuesday 2:30 pm–4:00 pm	Platform IIb: Teratology Society/OTIS Joint Session 2 Chairpersons: Kathie Johnson and Jan Freidman
2:30 – 2:45 pm	DESIGN OF A DATABASE OF HUMAN PRENATAL DRUG EXPOSURES ASSOCIATED WITH ADVERSE DEVELOPMENTAL OUTCOMES REPORTED TO FDA A. Vega and S. Tabacova, CDER/FDA and NCTR/ FDA, Rockville, Maryland
2:45 – 3:00 pm	ACCUTANE‘ - EXPOSED PREGNANCIES M.A. Honein and L. J. Paulozzi, Centers for Disease Control and Prevention, Atlanta, Georgia
3:00 – 3:15 pm	CONFIDENTIALITY AND DISCLOSURE ISSUES IN COUNSELING PREGNANT PATIENTS WHO REVEAL SUBSTANCE ABUSE: A CASE REPORT K. Filkins, S. Beverly, E. Chen, D Johnstone, J. Gordon, and N. Catalano, UCLA School of Medicine, Department of Obstetrics and Gynecology, Los Angeles, California; UCLA School of Medicine, Department of Clinical Social Work, Los Angeles, California; California Teratogen Information Service, University of California, San Diego Medical Center
3:15 – 3:30 pm	DOES DRUG LABELING INFLUENCE RISK PERCEPTIONS OF TERATOGENICITY? A SURVEY OF PREGNANT WOMEN AND THEIR HEALTH PROFESSIONALS A. Einarson, M.Pole, T.R. Einarson, N. Pairadeau, and G. Koren, The Motherisk Program, The Hospital for Sick Children, Faculty of Pharmacy, University of Toronto, and Obstetrics Dept, North York General Hospital, Toronto, Canada
3:30 – 4:00 pm	SELF-SELECTION BIAS IN TERATOLOGY INFORMATION SERVICE PREGNANCY OUTCOME STUDIES K.A. Johnson, P.A. Weber, C.D. Chambers, and K.L. Jones, Department of Pediatrics, Division of Dysmorphology and Teratology, University of California San Diego, La Jolla, California and Kaiser Permanente of Southern California, San Diego, California
Tuesday 1:00 pm – 2:30 pm	Platform IIIa: Hazard/Risk Assessment Session 1 Chairpersons: James Schardein and Patricia Bittner
1:00 – 1:15 pm	DEVELOPMENTAL TOXICITY INTERACTIONS OF METHANOL AND RADIOFREQUENCY (RF) RADIATION OR 2-METHOXYETHANOL (2ME) IN RATS B.K. Nelson, D.L. Snyder, and P.B. Shaw, Division of Biomedical and Behavioral Science, NIOSH, Cincinnati, Ohio
1:15 – 1:30 pm	ADDITIVITY OF CARBON MONOXIDE AND PROTEIN DEFICIENCY ON NEONATAL MORTALITY IN MICE J. Singh, Stillman College, Tuscaloosa, Alabama
1:30 – 1:45 pm	THE PREDOMINANT ROLE OF MATERNAL TOXICITY IN LOVASTATIN-INDUCED DEVELOPMENTAL TOXICITY L.D. Wise, M.A. Cukierski, G.R. Lankas, and G.L. Skiles, Merck Research Laboratories, West Point, Pennsylvania
1:45 – 2:00 pm	PREGNANCY ALTERS THE PHARMACOKINETICS OF CYSTEAMINE IN THE PREGNANT RAT AND EFFECTS POSTNATAL DEVELOPMENT L.B. Fawcett, D.A. Beckman, L.K. Sherrell, J.E Pugarelli, and F.K Assadi, Department of Medical Cell Biology, Alfred I. duPont Hospital for Children, Wilmington, Delaware
2:00 – 2:15 pm	LEFLUNOMIDE AS AN EXAMPLE OF A MODERN APPROACH TO PRODUCT LABELING FOR REPRODUCTIVE EFFECTS: A CATEGORY X DRUG BASED ON PHARMACOKINETIC DATA R.L. Brent, duPont Hospital for Children, Wilmington, Delaware
2:15 – 2:30 pm	THE EFFECTS OF IN UTERO EXPOSURE TO A LOW DOSE OF BISPHENOL A ON FEMALE SEXUAL MATURATION OF THE RAT C.E. Talsness and I. Chahoud, Institute of Clinical Pharmacology and Toxicology, Benjamin Franklin Medical Center, Freie Universitaet, Berlin, Germany
Tuesday 2:30 pm – 4:00 pm	Platform IIIb: Hazard/Risk Assessment Session 2 Chairpersons: Ed Carney and Steve Harris
2:30 – 2:45 pm	A THREE-DIMENSIONAL CULTURE SYSTEM SUPPORTS DEVELOPMENT OF INCISORS AND MOLARS IN MAXILLA AND MANDIBLE OF CULTURED MURINE FIRST ARCHES P. Williams, D. Montufar-Solis, and J. Duke, Dept. of Orthodontics, Dental Branch, UT Houston Health Science Center, Houston, Texas
2:45 – 3:00 pm	THE MECHANISM OF CLEFT PALATE FORMATION IN THE CHONDRODYSPLASIA MOUSE W. McLean, I.G. Lavrin, R.E. Seegmiller, C.W. Archer, E.D. Hay, and B.R. Olsen, Harvard Medical School and Harvard School of Dental Medicine, Boston, Massachusetts; Brigham Young University, Provo, Utah; and Cardiff University, Cardiff, UK
3:00 – 3:15 pm	DEVELOPMENTAL TOXICITY STUDIES WITH GLYPHOSATE AND SELECTED SURFACTANTS IN RATS D.R. Farmer, T.A Kaempfe, W.F. Heydens, and W.R. Kelce, Monsanto Company, St. Louis, Missouri
3:15 – 3:30 pm	RIO GRANDE RIVER WATER AND SEDIMENT EXTRACTS INDUCE NEURAL TUBE DEFECTS (NTD) IN XENOPUS D.J. Fort, E.L. Stover, J.A. Bantle, and J.G. Burkhart, The Stover Group, Stillwater, Oklahoma; Oklahoma State University Department of Zoology, Stillwater, Oklahoma; NIEHS, Research Triangle Park, North Carolina
3:30 – 3:45 pm	MECHANISMS FOR DEVELOPMENTAL TOXICITY OF TOMUDEX C. Lau, R.G. Hanson, D. Lui, M. L. Mole, M.G. Narotsky, J.M. Rogers and R.M. Zucker, Reproductive Toxicology Division, NHEERL, USEPA, Research Triangle Park, North Carolina
3:45 – 4:00 pm	MESOTRIONE: IS MOUSE THE RELEVANT MODEL FOR HUMANS OF THE DEVELOPMENTAL AND REPRODUCTIVE EFFECTS OF TYROSINE? W.M. Provan and R.W. Lewis, Zeneca Central Toxicology Laboratory, Macclesfield, Cheshire, UK
4:00 pm – 10:00 pm	Exhibits Open
4:30 pm – 6:00 pm	Business Meeting
Tuesday 7:30 pm – 10:00 pm	Poster Session Sponsored by Covance Laboratories, Quintiles, SNBL, Springborn Laboratories, Inc., and TherImmune Research Corporation
Wednesday, June 28 top
7:30 am – 8:15 am	Continental Breakfast
7:30 am – 5:00 pm	Registration
8:30 am – 12: 00 noon	Public Affairs Symposium: What Do We Know About the Reproductive & Developmental Risks of Herbal and Alternate Remedies? Chairpersons: Kenneth Jones and Harpal Buttar
8:30 – 8:45 am	INTRODUCTION H.S. Buttar, Bureau of Pharmaceutical Assessment, Health Protection Branch, Ottawa, Canada
8:45 – 9:15 am	POTENTIAL TOXICITIES OF HERBAL THERAPIES IN THE DEVELOPING FETUS T.M. Jurgens, College of Pharmacy, Dalhousie University, Halifax, Nova Scotia, Canada
9:15 – 9:45 am	HERBAL REMEDIES IN PREGNANCY - METHODOLOGICAL AND PRACTICAL ISSUE G. Koren, The Motherisk Program, Toronto, Ontario, Canada
9:45 – 10:15 am	INTERACTIONS OF HERBAL AND ALTERNATE REMEDIES WITH CONVENTIONAL MEDICINES B.A. Buehler, University of Nebraska Medical Center, Omaha, Nebraska
Wednesday 10:15 am - 10:45 am	WARKANY TEA
10:45 – 11:15 am	PREGNANCY OUTCOME IN WOMEN USING HERBAL AND ALTERNATE THERAPIES T. Johns, School of Dietetics and Human Nutrition, McGill University, Ste. Anne de Bellevue, Quebec, Canada
11:15 – 11:45 am	REGULATORY ISSUES CONCERNING THE SAFETY AND EFFICACY OF HERBAL AND ALTERNATIVE REMEDIES C.G. Rousseaux, Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ontario, Canada
11:45 – 12:00 pm	DISCUSSION K. Jones, Department of Pediatrics, Division of Dysmorphology and Teratology, University of California, San Diego, La Jolla, California
Wednesday 1:00 pm–4:45 pm	Workshop I Interpretation of Data on Developmental Neurotoxicity Chairpersons: Carole Kimmel and Deborah Rice
1:00 – 1:10 pm	WORKSHOP OVERVIEW C.A. Kimmel, USEPA, NCEA, Washington, District of Columbia
1:10 – 2:00 pm	NEUROBEHAVIORAL DATA INTERPRETATION IN NEUROTOXICITY STUDIES: FOB, MOTOR ACTIVITY AND FUNCTION V.C. Moser, USEPA, Research Triangle Park, North Carolina
2:00 – 2:50 pm	SENSORY SYSTEM TESTING L.D. Fechter, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
2:50 – 3:40 pm	INTERPRETATION OF TESTS OF COGNITIVE FUNCTION IN ANIMAL MODELS OF DEVELOPMENTAL NEUROTOXICOLOGY D.C. Rice, NCEA, USEPA, Washington, District of Columbia
3:40 – 4:30 pm	ASSESSMENT OF DEVELOPMENTAL NEUROTOXICITY IN HUMANS D.C. Bellinger, Children's Hospital, Boston, Massachusetts
4:30 – 4:45 pm	GENERAL DISCUSSION
Wednesday 1:00 pm – 4:00 pm	Workshop II Developmental Toxicokinetics: Lessons for Product Development Chairpersons: Rakesh Dixit and L. David Wise
1:00 – 1:10 pm	INTRODUCTION R. Dixit and L.D. Wise, Merck Research Laboratories, West Point, Pennsylvania
1:10 – 1:50 pm	ANATOMICAL AND DEVELOPMENTAL ASPECTS OF MATERNAL-EMBRYONIC-FETAL INTERFACE J. DeSesso, Biomedical Research Institute, Mitretek Systems, McLean, Virginia
1:50 – 2:10 pm	COMPARTMENTAL AND PHYSIOLOGICALLY-BASED TOXICOKINETICS IN RISK ASSESSMENT D. Clarke, Lilly Research Laboratories, A Division of Eli Lilly & Company, Greenfield, Indiana
2:10 – 2:30 pm	APPLICATIONS AND LIMITATION OF DEVELOPMENTAL TOXICOKINETIC STUDIES: MECHANISTIC VS. RISK ASSESSMENT R. Dixit, Department of Safety Assessment, Merck Research Laboratories (MRL), Merck and Company, Inc., West Point, Pennsylvania
2:30 – 4:00 pm	CLINICAL AND REGULATORY CONSIDERATIONS IN DEVELOPMENTAL TOXICOKINETICS P.J. Wier, Safety Assessment, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania
Wednesday 1:00 pm - 4:00 pm	Workshop III Teratology Society's Ethics Code, Certification, Disclaimer Guidelines and Expertise Recognition Chairpersons: Robert L. Brent, Narsingh Agnish, and Anthony R. Scialli
1:00 – 4:00 pm	OVERVIEW R.L. Brent, N. Agnish, and A.R. Sciali du Pont Hospital for Children, Wilmington, Delaware, Hoffman-LaRoche Inc., Nutley, New Jersey, and Georgetown University, Washington, District of Columbia
Wednesday 4:00 pm – 5:00 pm	Historical Control Database Demonstration Kok-Wah Hew and L. David Wise
4:00 pm – 6:00 pm	Council II Meeting
6:30 pm – 7:30 pm	Banquet Reception
6:30 pm – 7:30 pm	President's Circle Reception (By Invitation Only)
Wednesday 7:30 pm – 10:30 pm	Banquet
Thursday, June 29 top
7:30 am – 8:15 am	Continental Breakfast
7:30 am – 5:00 pm	Registration
8:30 am–10:00 am	Platform IVa: Clinical Teratology Chairpersons: Jeanne Manson and Lewis Holmes
8:30 – 8:45 am	IDENTIFYING CRITICAL WINDOWS OF EXPOSURE FOR CHILDREN'S HEALTH S.G. Selevan, C.A. Kimmel, and P. Mendola, USEPA, NCEA, Washington, DC, and NHEERL, Research Triangle Park, North Carolina
8:45 – 9:00 am	CONGENITAL LATERAL RECTUS DEFICITS AND ASSOCIATED MALFORMATIONS AND SYNDROMES M.T. Miller and K. Str›mland, University of Illinois at Chicago, Department of Ophthalmology, Chicago, Illinois; The Queen Silvia Children's Hospital, Department of Pediatric Ophthalmology, G›teborg, Sweden
9:00 – 9:15 am	CHANGES IN CRANIOFACIAL FEATURES IN CHILDREN EXPOSED TO ANTIEPILEPTIC DRUGS IN UTERO H.I. Orup, Jr., B.A. Coull, J. Adams, L.M. Ryan and L.B. Holmes. Genetics and Teratology Unit, Pediatric Service, Massachusetts General Hospital; Department of Biostatistics, Harvard School of Public Health; and Department of Psychology, University of Massachusetts, Boston, Massachusetts
9:15 – 9:30 am	THE CHILDREN OF THE SWEDES WITH THALIDOMIDE EMBRYOPATHY K. Str›mland, M. Andersson Gr›nlund, and E. Philipsson, The Queen Silvia Children's Hospital, Department of Pediatric Ophthalmology, G›teborg University, G›teborg, Sweden
9:30 – 9:45 am	SURVIVAL OF INFANTS WITH SPINA BIFIDA AND ENCEPHALOCELE: A POPULATION STUDY, 1979-1994 L-Y.C. Wong and L. Paulozzi, Centers for Disease Control and Prevention, Atlanta, Georgia
9:45 – 10:00 am	NONGENITAL MALFORMATIONS AND EXPOSURE TO PROGESTATIONAL DRUGS DURING PREGNANCY: THE FINAL CHAPTER OF AN ERRONEOUS ALLEGATION R.L. Brent, duPont Hospital for Children, Wilmington, Delaware
Thursday 10:00 am–11:45 am	Platform IVb: Epidemiology Chairperson: Joe Lary
10:00 – 10:15 am	GENOTYPES OF HOXA1 AND HOXB1 AND GENDER: SUSCEPTIBILITY TO AUTISM SPECTRUM DISORDERS P.M. Rodier, C.J. Stodgell, L.W. Weitkamp, J.L. Ingram, S.L. Hyman, and D.A. Figlewicz, Departments of OB/GYN, Psychiatry, Pediatrics, and Neurology, University of Rochester, Rochester, New York
10:15 – 10:30 am	MATERNAL AND FETAL GENOTYPIC EFFECTS: TRANSFORMING GROWTH FACTOR ALPHA AND ORAL CLEFTS AS AN EXAMPLE OF A NEW PARADIGM D.F. Wyszynski, T. Wu, M.H. Khoshnevisan, A. Miller-Chisholm, M. Mazaheri, R.E. Long Jr., and S.R. Diehl, Boston University School of Medicine, Boston, Massachusetts; NIDCR, NIH, Bethesda, Maryland; Lancaster Cleft Palate Clinic, Lancaster, Pennsylvania
10:30 – 10:45 am	TRANSFORMING GROWTH FACTOR BETA 3 AND OROFACIAL CLEFTS P.A. Romitti, A.C. Lidral, J.C. Murray, S. Daack-Hirsch, and T.L. Burns, University of Iowa, Iowa City, Iowa
10:45 – 11:00 am	GASTROSCHISIS PREVALENCE RATES: NO SECULAR TRENDS IN CALIFORNIA, FROM 1984 TO 1996 C.P. Torfs and K. Deosaransingh, California Birth Defects Monitoring Program, Emeryville, California
11:00 – 11:15 am	LOWERED WEIGHT GAIN DURING PREGNANCY AND RISK OF NEURAL TUBE DEFECTS AMONG OFFSPRING G.M. Shaw, K. Todoroff, S.L. Carmichael, D.M. Schaffer, and S. Selvin, California Birth Defects Monitoring Program, Emeryville, California
11:15 – 11:30 am	PERICONCEPTIONAL INTAKE OF VITAMIN SUPPLEMENTS AND RISK OF MULTIPLE CONGENITAL ANOMALIES G.M. Shaw, L.A. Croen, K. Todoroff, and M.M. Tolarova, California Birth Defects Monitoring Program, Emeryville, California
11:30 – 11:45 am	EVALUATION OF MARKERS FOR EARLY DETECTION OF PREGNANCY IN AN AUTOMATED DATABASE J. Manson, B. McFarland, S. Weiss, C. Corelle, University of Pennsylvania, Philadelphia, Pennsylvania; Kaiser Permanente Center for Health Research, Portland, Oregon; University of Maryland, Baltimore, Maryland
Thursday 9:00 am–10:15 am	Platform Va: Modes of Action Session 1 Chairpersons: Dana Shuey and Neil Chernoff
9:00 – 9:15 am	EFFECTS OF VLA-4 ANTAGONISTS IN RAT WHOLE EMBRYO CULTURE S. Spence, C. Vetter, W. Hagmann, R. Mumford, G. Van Riper, H. Williams, and J. Schmidt, Developmental & Reproductive Toxicology, Medicinal Chemistry, Pharmacology & Inflammation Research, Merck Research Labs, West Point, Pennsylvania
9:15 – 9:30 am	ACTIVATION OF CASPASE-9 IN DAY 9 MOUSE EMBRYOS EXPOSED IN VITRO TO HYPERTHERMIA, 4-HYDROPEROXYCYCLO- PHOSPHAMIDE, AND STAUROSPORINE S.A. Little and P.E. Mirkes, Department of Pediatrics, University of Washington, Seattle, Washington
9:30 – 9:45 am	ANTIOXIDANT AMELIORATION OF ARSENICAL-INDUCED EFFECTS IN VIVO E.S. Hunter and E.H. Rogers, Reproductive Toxicology Division, NHEERL, USEPA, Research Triangle Park, North Carolina
9:45 – 10:00 am	EFFECTS OF TROGLITAZONE AND AMINOGLUTETHIMIDE ON RAT PLACENTAL AND FETAL WEIGHTS P.J. Wier, E.A. Zahalka, S. Rehm, R. Kuk, A. Nix, and S. Murzyn, Safety Assessment, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania
10:00 – 10:15 am	HOMOCYSTEINE THIOLACTONE DOES NOT PRODUCE NEURAL TUBE DEFECTS IN MOUSE EMBRYOS IN VITRO D.K. Hansen, T.F. Grafton, S. Melnyk and S.J. James, National Center for Toxicological Research, Jefferson, Arkansas
Thursday 10:15 am–11:30 am	Platform Vb: Modes of Action Session 2 Chairpersons: Stan Spence and Cathy Price
10:15 – 10:30 am	COMPARATIVE DEVELOPMENTAL TOXICITY OF THE GLYCOL ETHER METABOLITES, METHOXYACETIC ACID AND METHOXYPROPIONIC ACID E.W. Carney and K.A. Johnson, The Dow Chemical Company, Midland, Michigan
10:30 – 10:45 am	INHIBITION OF NEURAL CREST CELL MIGRATION BY THE WATER DISINFECTION BYPRODUCT BROMOCHLORO ACETIC ACID J.E. Andrews, H. Nichols, J. Schmid, G. Klinefelter and E.S. Hunter, Reproductive Toxicology Division and Research Support Division, NHEERL, USEPA, Research Triangle Park, North Carolina
10:45 – 11:00 am	Cu DEFICIENCY ALTERS CARDIOVASCULAR STRUCTURE AND EXTRACELLULAR MATRIX (ECM) PROTEIN EXPRESSION DURING MURINE DEVELOPMENT L. Lanoue, M.E. Beckers, T.E. Landerholm, R.B. Rucker, C.L. Keen and J.Y. Uriu-Adams, Nutrition Dept., University of California at Davis, Davis, California
11:00 – 11:15 am	THE TOXIC MECHANISM OF ALLANTOIC AGENESIS IN DCF TREATED EARLY POSTIMPLANTATION MOUSE EMBRYOS M.J. Airhart, T.E. Kwasigroch, and R.G. Skalko, Department of Anatomy and Cell Biology, East Tennessee State University, Johnson City, Tennessee
11:15 – 11:30 am	MICROARRAY ANALYSIS OF ALTERED GENE EXPRESSION IN THE TESTES OF FETAL RATS EXPOSED TO DBP V.D. Shultz, S.L. Phillips, P.M.D. Foster, and K.W. Gaido, CIIT, Research Triangle Park, North Carolina
Thursday 12:00 noon – 1:00 pm	James G. Wilson and F. Clarke Fraser Awards Luncheon

Oral Presentations
Each platform paper, except for those presented in the symposia, will be allowed 15 minutes (12 minutes for presentations and 3 minutes for discussion). The time schedule will be strictly followed. Projectors for 35 mm slides will be available in each meeting room. Please keep slides simple and uncluttered.

A good rule of thumb is, if you cannot read your slide without magnification, those in the middle and rear of the room will be unable to read it when presented. One concept per slide and a maximum rate of one slide per minute, are also good rules to follow for effective presentations.

Poster Presentations
Poster material should be organized within a 4 ft. x 8 ft. area. The top of your poster board should contain the following information, with letters at least 3/4 inches high:

1. Your poster number
2. Title
3. Authors
4. Affiliations

A copy of the abstract should be posted towards the upper-left corner, and a set of conclusions toward the lower- right corner of your poster. These should be printed in letters about 1/4 inch high. Poster information should be legible from a distance of at least 3 to 4 feet. Material, including line drawings, should be clearly presented and may be computer generated (laser printer is preferable). PLEASE BRING YOUR OWN PUSH-PINS. Poster sessions and times for setup and removal are indicated in the Program.

Posters should be on display from 11:00 AM - 10:00 PM on Monday, June 26, or 11:00 AM - 10:00 PM on Tuesday, June 27. Those presenting should plan to be present on Monday or Tuesday evenings from 7:30 PM - 10:00 PM. All posters should be removed immediately following the poster session at which you presented (10:00 PM).

SIGNAL TRANSDUCTION:
Pathways to Growth, Differentiation, and Morphogenesis

This year's Continuing Education Course will focus on signal transduction and the role of selected cellular signaling pathways in morphogenesis. The course lectures will be presented in sequence focusing on signal transduction from the outside of the cell (extracellular matrix and cell adhesion molecules), to the plasma membrane (growth factor receptors and heterotrimeric G proteins), cytoplasm (protein kinases), and nucleus (nuclear receptors and transcription factors). Each lecturer will review a selected signal transduction pathway and its role in normal and abnormal development as demonstrated by the use of specific inhibitors of the pathway, genetic mutations, and/or animal models such as knockouts.
In addition to the cell surface to nuclear review of cellular signaling outlined above, three signal transduction pathways known to play significant roles in development have been selected for review and discussion. The three pathways are vascular endothelial growth factor mediated signaling, the endothelin receptor mediated pathway, and peroxisome proliferator-activated receptor mediated signaling. This year's course will provide an overview of the field of signal transduction and the highlight importance of this field of research for Teratologists.

Saturday, June 24, 2000

1:00 – 1:05	Welcome – George Daston, President, Teratology Society
1:05 – 1:10	Introduction – JoLynda Jones, Bristol-Myers Squibb
1:15 – 2:00	CELL ADHESION MOLECULES AND SIGNAL TRANSDUCTION: BIDIRECTIONAL INTERFACE FOR REGULATION OF DEVELOPMENT SPEAKER: Gerald Grunwald, Thomas Jefferson University
2:00 – 2:45	TRANSFORMING GROWTH FACTORS-ã : IMPORTANT MEDIATORS OF MAMMALIAN DEVELOPMENT SPEAKER: Kathy Flanders, National Cancer Institute
2:45 – 3:30	G PROTEINS: MASTER SWITCHES IN CELLULAR SIGNAL TRANSDUCTION SPEAKER: Cynthia Ward, University of Pennsylvania
3:30 – 3:45	COFFEE BREAK
3:45 – 4:30	PROTEIN KINASE C SPEAKER: Sidney Hunter, US Environmental Protection Agency
4:40 – 5:15	RETINOIDS SIGNALING AND EMBRYOGENESIS SPEAKER: Devendra Kochhar, Thomas Jefferson University

Sunday, June 25, 2000

7:30 – 8:15	CONTINENTAL BREAKFAST
8:15 – 9:00	SIGNAL TRANSDUCTION PATHWAYS REGULATING CELL DEATH (APOPTOSIS) OR CELL SURVIVAL SPEAKER: Philip E. Mirkes, University of Washington
9:00 – 9:45	VASCULOGENESIS AND ANGIOGENESIS: A CRITICAL GENE PATHWAY FOR EMBRYONIC DEVELOPMENT SPEAKER: Barbara Abbott, US Environmental Protection Agency
9:45 – 10:15	COFFEE BREAK
10:15 – 11:00	ENDOTHELIN SPEAKER: Deepak Srivastava, University of Texas Southwestern Medical Center
11:00 – 11:45	ROLES OF THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPARs) IN DEVELOPMENT SPEAKER: Jeffrey M. Peters, Pennsylvania State University
11:45 – 12:00	DISCUSSION / ADJOURNMENT

(As of April 1, 2000)

The Teratology Society thanks the following organizations for their participation as exhibitors at the 2000 Annual Meeting in Palm Beach, Florida.

Aventis
Bayer Corporation
Chevron Corporation
Coca-Cola Company
Eastman Kodak Company
Glaxo Wellcome
Hoffmann-La Roche, Inc.
Huntingdon Life Sciences
Merck Research Laboratories
Pfizer, Inc.
Primedica Argus Research Laboratories, Inc.
Sanofii-Synthelabo Research
Schering-Plough Research
SmithKline Beecham Pharmaceuticals
Springborn Laboratories, Inc.
Valent U.S.A. Corporation
WIL Research Laboratories, Inc.

Sustaining Members

American Petroleum Institute
Bristol-Meyers Squibb Company
ClinTrials BioResearch, Ltd., (CTBR)
Covance Laboratories
Dow Corning Corporation
Eli Lilly and Company
Exxon Mobil Biomedical Sciences
Mitretek Systems
Pharmacia & Upjohn, Inc.
Procter & Gamble Company
R.W. Johnson Pharmaceutical Research Institute, Ltd.
Warner Lambert Company
Wyeth-Ayerst Research

2000 Annual Meeting Sponsors

The Teratology Society thanks the following year 2000 Sponsors
(As of April 18, 2000)

Aventis
Covance Laboratories, Inc.
Eli Lilly & Company
Elsevier Science, Inc.
John Wiley & Sons
March of Dimes
Merck Research Laboratories
Middle Atlantic Reproduction and
Teratology Association
Midwest Teratology Association
Pfizer, Inc.
Primedica Argus Research Laboratories, Inc.
Proctor & Gamble Company
Quintiles Toxicology/Pathology
SNBL USA, Ltd.
Springborn Laboratories, Inc.
TherImmune Research Corporation
WIL Research Laboratories

rev. 10-Jun-2003

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