|
2000
Meeting Highlights
Registration
Information
The
deadline for advanced registration for the 2000 Teratology
Society Annual Meeting is May 24, 2000.
After May 24, a late fee of $40 will apply.
| Why
Attend the 2000 Teratology Society Meeting? |
|
The
annual meeting provides attendees with comprehensive coverage
of teratology-contributed papers and symposia present the
latest research in our field. It is a way to make contact
with others and with ourselves, a reminder of why we went
into this field and of our goals to understand abnormal development
and to learn how to prevent abnormal reproductive outcomes.
The meeting and relaxed setting provide a once-a-year opportunity
to network with old friends, mentors and students and give
us a sounding board for our ideas. We have increased the number
of exhibitors over the past couple of years, which broadens
your ability to learn about products and services offered
to enhance teratological research. The recipe is perfect for
an enjoyable few days, after which we can return home with
our batteries recharged, ready for another year in the lab
or the clinic.
Scientific Program
The Program Committee has put together a full meeting agenda
with five major symposia, contributed papers and poster sessions.
The symposia include: Genetic Susceptibility to Teratogenesis,
sponsored by the March of Dimes and presented jointly by the
Teratology Society and OTIS; Folate Supplementation and Birth
Defects, presented jointly by the Teratology Society, NBTS
and OTIS; Angiogenesis, sponsored by Wiley-Liss; What Do We
Know about the Reproductive & Developmental Risks of Herbal
and Alternate Remedies?, presented by the Public Affairs Committee;
Developmental Risks of Disinfectant By-Products. This year's
Warkany Lecturer is William J. Scott, Jr. The first presentation
of the James G. Wilson Publication Award will be made on Monday,
June 26. In addition to the more formal sessions, workshops
will be presented on Wednesday, June 28 on developmental toxicokinetics,
the interpretation of data on developmental neurotoxicity,
and the Society's Code of Ethics. Due to the popularity of
evening poster sessions, we will hold two of these sessions
again at this year's meeting.
Teratology Society Education Course
The Education Committee has put together a course that will
focus on signal transduction and the role of selected cellular
signaling pathways in morphogenesis. The course lectures will
be presented in sequence focusing on signal transduction from
the outside of the cell (extracellular matrix and cell adhesion
molecules), to the plasma membrane (growth factor receptors
and heterotrimeric G proteins), cytoplasm (protein kinases),
and nucleus (nuclear receptors and transcription factors).
Each lecturer will review a selected signal transduction pathway
and its role in normal and abnormal development as demonstrated
by the use of specific inhibitors of the pathway, genetic
mutations and/or transgenic animal models. The course will
begin on the afternoon of Saturday, June 24 and conclude on
the morning of Sunday, June 25.
Graduate Student and Post-Doc Career Event
Sponsored by MARTA and MTA
All graduate students and post-docs are invited to meet
the officers and committee members of MARTA (Middle Atlantic
Reproduction and Teratology Association) and MTA (Midwestern
Teratology Association), share some refreshments, and discuss
life after graduate school. Job search strategies, career
options and career development in developmental and reproductive
toxicology within industry, government, contract research
organizations and other segments of our field. It is a good
opportunity to make contacts, evaluate career options and
begin to plan for the future.
Mark your calendars for Monday evening, June 26th from 6:00
PM to 7:30 PM. Bring your appetites and questions about your
future!
Three Penny Swing-Banquet Entertainment
Sponsored by WIL Research
Don't forget to pack your dancing shoes, because at this year's
Banquet we're going to shake up The Breakers with music by
Three Penny Swing, a 6-piece swing band led by teratologist/saxophonist
Ed Carney. This sonic tour de force, with its mix of Y2K-compliant
and traditional swing, rock-a-billy R&B, and Latin dance
music, is sure to induce morphogenetic movements of even the
most stoic teratologist. Whether you just nod your head, tap
your toes, or conquer the dance floor, we know you'll be in
for a good time!
In the meantime, a sneak peak of the band can be had at: www.threepennyswing.com.
What Does the Meeting Registration Fee Cover?
The meeting registration fee covers a number of food and beverage
functions, as well as the Society's administrative costs for
the meeting. The functions include Continental Breakfast each
morning, the Banquet, the Wilson Awards Luncheon, and coffee
and refreshment breaks. We will also have a President's Reception
and a reception during each of the poster sessions; these
are being sponsored. The registration fee is comparable to
past years.
The deadline for advanced registration is May 24, 2000. After
that date, a late fee of $40 will apply.
The Registration Desk will be open at the meeting from Saturday,
June 24-Tuesday, June 27. Please see the Program Agenda on
pages 6-7 for specific times.
Sponsorship Opportunities
Event sponsorship opportunities are available for the 2000
Teratology Society Annual Meeting. Events to be sponsored
include:
Meeting
Site
The Breakers earned the Mobil Travel Guide Five Star Award
once again-just two years after reclaiming the AAA five diamond
Award (only 16 properties in the U.S. have both).
- Climate
and Suggested Dress - Palm Beach enjoys a year-round
average temperature in the low 80s. In the daytime, sportswear
and casual attire are worn throughout the resort. Collared
sport shirts are preferred for gentlemen. In the evening,
jackets are recommended for gentlemen only in The Florentine.
Proper golf and tennis attire and sport shoes are required.
- Shopping
- Recognizing that shopping tops the list of preferred
activities for vacationers, The Breakers has created an
elegant on-property Villa filled with exquisite boutiques.
This collection of beautifully designed shops features
a unique selection of fine glass, clothing, jewelry, foods,
wines and gifts.
- Dining
and Entertainment - The Breakers offers seven restaurants
and four bars; each having a unique menu and atmosphere.
Enjoy classic European cuisine in The Florentine or relax
on the beach at the Reef Bar overlooking the beautiful
Atlantic Ocean.
- Transportation
- Limousines, sedans, vans and busses are available
for all of your transportation needs; reservations are
suggested.
- Guest
Business Services - The Guest Business Services offers
personal computers, laptops, printers, and copy and facsimile
machines for rental with advance notification.
- Concierge
- For information about area attractions or for assistance
with advance reservations call 1-800-752-8285.
Updated 24-Apr-2000
|
| Saturday, June 24 |
| 11:00
am – 5:00 pm |
Registration |
| 12:00
pm – 6:00 pm |
Council
IA Meeting |
| 1:00
pm – 5:15 pm |
Education
Course:
Signal
Transduction: Pathways to Growth, Differentiation, and Morphogenesis
|
|
|
| |
| 7:30
am – 5:00 pm |
Registration |
| 7:00
am – 2:00 pm |
Council
IB Meeting |
| 8:15
am – 12:00 noon |
Education
Course (Continued from Saturday) |
| 1:30
pm – 5:00 pm |
March
of Dimes Symposium:
Genetic
Susceptibility to Teratogenesis
Chairpersons: Mike Collins and Michael Katz
Supported in part by March of Dimes Birth Defects Foundation Grant
No.4-FY96-8960
|
|
1:30
– 1:40 pm
|
INTRODUCTION
M.D.
Collins, UCLA, Los Angeles, California and
M. Katz, March of Dimes, White Plains, New York
|
|
1:40
– 2:20 pm
|
GENE-ENVIRONMENT
INTERACTIONS IN BIRTH DEFECTS
J.C.
Murray, The University of Iowa, Department of Pediatrics, Iowa City,
Iowa
|
|
2:20
– 2:50 pm
|
WHOLE
GENOME SCAN TO IDENTIFY CHROMOSOMAL LOCI ASSOCIATED WITH A STRAIN
DIFFERENCE IN SUSCEPTIBILITY TO CADMIUM-INDUCED FORELIMB DEFECTS
M.D.
Collins, UCLA, Los Angeles, California
|
|
2:50
– 3:05 pm
|
BREAK
|
|
3:05
– 3:35 pm
|
INSIGHTS
FROM GENOME SCANS VERSUS CANDIDATE GENE POLYMORPHISMS FOR UNDERSTANDING
THE ETIOLOGY OF TERATOGEN-INDUCED ORAL CLEFTS IN MOUSE AND MAN
S.R.
Diehl, Craniofacial Epidemiology and Genetics Branch, NIDCR, NIH,
Bethesda, Maryland
|
|
3:35
– 4:05 pm
|
INTERPRETATION
OF TERATOGENETICS
D.M.
Juriloff, Department of Medical Genetics, University of British
Columbia, Vancouver, B.C., Canada
|
|
4:05
– 5:00 pm
|
HOLOPROSENCEPHALY
AS A MODEL TO UNDERSTAND BRAIN DEVELOPMENT
M.
Muenke, Medical Genetics Branch, National Human Genome Research
Institute, NIH, Bethesda, Maryland, and The Children's Hospital
of Philadelphia, University of Pennsylvania School of Medicine,
Philadelphia, Pennsylvania
|
| 6:00
pm – 7:30 pm |
President's
Reception (Sponsored by Elsevier) |
| 6:00
pm – 7:30 pm |
Exhibits
Open |
|
|
| |
| 7:00
am – 7:45 am |
Continental
Breakfast |
| 7:30
am – 5:00 pm |
Registration |
| 7:45
am – 8:00 am |
President's
Welcome and Introduction
George
P. Daston
|
| 8:00
am – 8:45 am |
Warkany
Lecture
William
J. Scott, Jr., University of Cincinnati
|
Monday
9:00 am – 12:10 pm |
Wiley-Liss
Symposium
Angiogenesis
Chairpersons:
William Slikker, Jr. and Karen Augustine
Sponsored by John Wiley & Sons, Inc.
|
|
9:00
– 9:10 am
|
OVERVIEW
K.A.
Augustine and W. Slikker
|
|
9:10
– 9:50 am
|
ENDOTHELIAL
CELL ORIGINS AND BLOOD VESSEL MORPHOGENESIS
T.J.
Poole, Department of Cell and Developmental Biology, Upstate Medical
University, Syracuse, New York
|
|
9:50
– 10:30 am
|
REGULATION
OF VASCULOGENESIS AND ANGIOGENESIS
B.D.
Abbott, Reproductive Toxicology Division, USEPA, Research Triangle
Park, North Carolina
|
|
10:30
– 10:45 am
|
BREAK
|
|
10:45
– 11:25 am
|
MOLECULAR
DETERMINANTS OF VASCULOGENIC MIMICRY BY AGGRESSIVE TUMOR CELLS:
NEW THERAPEUTIC TARGETS FOR CLINICAL INTERVENTION
M.J.C.
Hendrix, The University of Iowa Cancer Center, Iowa City, Iowa
|
|
11:25
am–12:10 pm
|
ANTI-ANGIOGENIC
THERAPIES INCLUDING THALIDOMIDE
D.I.
Stirling, Celgene Corporation, Warren, New Jersey
|
Monday
12:00 – 1:00 pm |
Past
Presidents' Luncheon
Sponsored by Proctor & Gamble Company
(By Invitation Only) |
| 1:00
pm – 1:45 pm |
James
G. Wilson Publication Award |
| |
|
Monday
1:45 pm – 3:15 pm |
Platform
Ia: Student Plenary Session 1
Chairpersons: Kit Keller and Craig Harris |
|
1:45
– 2:00 pm
|
EFFECTS
OF SERA FROM WOMEN WITH SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) AND
RECURRENT ABORTIONS ON HUMAN PLACENTAL EXPLANTS IN CULTURE
S.
Yacobi, A. Ornoy, and R.K. Miller, Hebrew University Hadassah Medical
School, Jerusalem, Israel; University of Rochester, Rochester, New
York
|
|
2:00
– 2:15 pm
|
HIV-1
INFECTION IN EARLY HUMAN PLACENTAE IN VITRO: EFFECTS OF TUMOR
NECROSIS FACTOR (TNFa) AND INTERLEUKINS (IL-1 & IL-6)
Y.
Ding, T. Laughlin, B.M. Polliotti, and R.K. Miller, University of
Rochester, Rochester, New York
|
|
2:15
– 2:30 pm
|
CASPASE-3
ENZYME ACTIVITY AS A MARKER FOR TERATOGEN-INDUCED APOPTOSIS IN
DAY 9 MOUSE EMBRYOS AND ASSOCIATED YOLK SACS: EVIDENCE FOR YOLK
SAC RESISTANCE TO TERATOGEN-INDUCED APOPTOSIS
D.
Soleman and P.E. Mirkes, Department of Pediatrics, University of
Washington, Seattle, Washington
|
|
2:30
– 2:45 pm
|
LASER
CAPTURE MICRODISSECTION TO EXPLORE A POTENTIAL RELATIONSHIP BETWEEN
DIFFERENTIAL GENE EXPRESSION AND ETHANOL-INDUCED APOPTOSIS
W.C.
Dunty, Jr., P.S. Stockton, R.C. Barber, R.H. Finnell, M. Miles,
S.-Y. Chen, D.B. Dehart, and K.K. Sulik, Dept. of Cell Biology and
Anatomy, University of North Carolina at Chapel Hill, Chapel Hill,
North Carolina; Laboratory of Experimental Pathology, NIEHS, Research
Triangle Park, North Carolina; Center for Human Molecular Genetics,
University of Nebraska Medical Center, Omaha, Nebraska; and Dept.
of Neurology, Ernest Gallo Clinic and Research Center, University
of California, San Francisco, California
|
|
2:45
– 3:00 pm
|
EFFECT
OF DEVELOPMENTAL EXPOSURE TO ETHANEDIMETHANE SULPHONATE (EDS),
BROMOCHLOROACETIC ACID (BCA) AND MOLINATE ON WHOLE BODY TESTOSTERONE
LEVELS IN CD-1 MICE
D.K.
Tarka, G.R. Klinefelter, J. Suarez, and J.M. Rogers, University
of North Carolina, School of Medicine, Curriculum in Toxicology,
Chapel Hill, North Carolina; USEPA, NHEERL, Reproductive Toxicology
Division, Research Triangle Park, North Carolina
|
|
3:00
– 3:15 pm
|
DIABETIC
EMBRYOPATHY: IMPACT OF THE SPLOTCH ALLELE
A.F.
Machado, E.F. Zimmerman, D.H. Hovland Jr., R. Weiss, and M.D. Collins,
UCLA, Los Angeles, California; Children's Hospital Research
Found., Cincinnati, Ohio
|
| |
|
Monday
3:15
pm–4:30 pm |
Platform
Ib: Student Plenary Session 2
Chairpersons: Janet Uriu-Adams and Jack Bishop |
|
3:15
– 3:30 pm
|
ENDOTHELIN-A
RECEPTOR ANTAGONISM IN EMBRYO CULTURE: WINDOW OF SENSITIVITY AND
TIMING OF DEFECT
K.C.
Brannen, J.M. Rogers, and E.S. Hunter, Curriculum in Toxicology,
University of North Carolina, Chapel Hill, North Carolina, and Reproductive
Toxicology Division, NHEERL, USEPA, Research Triangle Park, North
Carolina
|
|
3:30
– 3:45 pm
|
DIFFERENTIAL
EXPRESSION OF CELL CHECKPOINT REGULATOR/DNA DAMAGE SENSOR GENES
DURING RAT EMBRYO ORGANOGENESIS IN
VIVO AND IN
VITRO
R.K.
Vinson and B. F. Hales, McGill University, MontrÃal, QC, Canada
|
|
3:45
– 4:00 pm
|
PK11195
INFLUENCES BIOGENESIS OF THE MOUSE mTDNA GENOME DURING NEURULATION
R.J.
Donahue, R.C. Craig, K.B. Knudsen, and T.B. Knudsen, Department
of Pathology, Anatomy and Cell Biology, Jefferson Medical College,
Philadelphia, Pennsylvania
|
|
4:00
– 4:15 pm
|
METHYLMERCURY
TRANSIENTLY ALTERS MITOCHONDRIAL GENE EXPRESSION IN THE EMBRYO:
EVIDENCE FOR DISRUPTION OF THE CELLULAR HEME PATHWAY
M.F.
O'Hara and T.B. Knudsen, Department of Pathology, Anatomy
and Cell Biology, Jefferson Medical College, Philadelphia, Pennsylvania
|
|
4:15
– 4:30 pm
|
ANALYSIS
OF MITOCHONDRIAL GENE EXPRESSION IN AN INTERVENTION MODEL FOR
TERATOGENESIS
J.H.
Charlap, R.C. Craig, and T.B. Knudsen, Department of Pathology,
Anatomy and Cell Biology, Jefferson Medical College, Philadelphia,
Pennsylvania
|
| 4:00
pm – 10:00 pm |
Exhibits
Open |
| 4:30
pm – 6:00 pm |
Issues
Forum |
Monday
6:00 pm – 7:30 pm |
Student
Career Event
Jointly
sponsored by Aventis, MARTA, MTA, and Pfizer, Inc.
|
| 7:30
pm – 10:00 pm |
Poster
Session
Sponsored
by Covance Laboratories, Quintiles, SNBL, Springborn Laboratories,
Inc., and TherImmune Research Corporation
|
|
|
| |
| 7:30
am – 8:15 am |
Continental
Breakfast |
| 7:00
am – 8:00 am |
Exhibitor's
Breakfast (By Invitation Only) |
| 7:30
am – 5:00 pm |
Registration |
| 8:30
am – 11:45 am |
NBTS/OTIS/Teratology
Society Symposium
|
|
8:30
– 8:35 am
|
INTRODUCTION
D.K
Hansen, National Center for Toxicological Research, Jefferson, Arkansas
|
|
8:35
– 9:10 am
|
POTENTIAL
MECHANISM(S) FOR FOLATE PREVENTION OF NEURAL TUBE DEFECTS
D.K
Hansen, National Center for Toxicological Research, Jefferson, Arkansas
|
|
9:10
– 9:45 am
|
SUPPLEMENTATION
WITH METHYL GROUP DONORS, FOLATE OR CHOLINE, DURING LATE PREGNANCY
IN RATS IMPROVES VISUOSPATIAL MEMORY PERFORMANCE OF THE OFFSPRING
C.L.
Williams, Department of Psychology: Experimental, Duke University,
Durham, North Carolina
|
|
9:45
– 10:00 am
|
BREAK
|
|
10:00
– 10:35 am
|
NATIONAL
FOLIC ACID FORTIFICATION: HOW WE GOT THERE AND NEXT STEPS
E.A.
Yetley, Center for Food Safety and Applied Nutrition, FDA, Washington,
District of Columbia
|
|
10:35
– 11:10 am
|
PRE-
AND POST-FORTIFICATION MONITORING OF FOLATE AND VITAMIN B12 STATUS
P.F.
Jacques, Jean Mayer-USDA Human Nutrition Research Center on Aging
at Tufts University, Boston, Massachusetts
|
|
11:10
– 11:45 am
|
MONITORING
CHANGES IN NEURAL TUBE DEFECT RATES — PRE- AND POST-FORTIFICATION
J.D.
Erickson, Centers for Disease Control and Prevention, Atlanta, Georgia
|
| |
|
Tuesday
8:30 am – 12:00 noon |
Symposium
Developmental
Risks of Disinfectant By-Products Symposium
Chairperson: E. Sidney Hunter
|
|
8:30
– 8:45 am
|
SYMPOSIUM
OVERVIEW
E.S. Hunter, Reproductive Toxicology
Division, NHEERL, USEPA, Research Triangle Park, North Carolina
|
|
8:45
– 9:25 am
|
OCCURRENCE
OF DISINFECTION BY-PRODUCTS IN DRINKING WATER: IMPLICATIONS FOR
EPIDEMIOLOGY AND TOXICOLOGY STUDIES
S.W.
Krasner, Metropolitan Water District of Southern California, La
Verne, California
|
|
9:25
– 10:00 am
|
REPRODUCTIVE
AND DEVELOPMENTAL EFFECTS OF DISINFECTION BY-PRODUCTS IN DRINKING
WATER
J.S.
Reif, Department of Environmental Health, Colorado State University,
Ft. Collins, Colorado
|
|
10:00
– 10:15 am
|
BREAK
|
|
10:15
– 10:45 am
|
TRIHALOMETHANE-INDUCED
PREGNANCY LOSS IN RATS
M.
Narotsky, Reproductive Toxicology Division, NHEERL, USEPA, Research
Triangle Park, North Carolina
|
|
10:45
– 11:25 am
|
BIOMARKERS
OF TRICHLOROETHYLENE EXPOSURE
O.
Selmin, Pediatric Cardiology, College of Medicine, University of
Arizona Health Sciences Center, Tucson, Arizona
|
|
11:25
– 12:00 pm
|
IN
VITRO AND IN
VIVO REPRODUCTIVE AND DEVELOPMENTAL
TOXICITY OF DRINKING WATER DISINFECTION BY-PRODUCTS
R.
Tyl, Center for Life Sciences and Toxicology, Research Triangle
Institute, Research Triangle Park, North Carolina
|
| |
|
Tuesday
1:00 pm – 2:30 pm |
Platform IIa: Teratology Society/OTIS Joint Session 1
Chairpersons: Karen Filkins and Ashner Ornoy |
|
1:00
– 1:15 pm
|
DO
ANTIEPILEPTIC DRUGS COMBINED WITH CAFFEINE INCREASE THE RISK OF
BIRTH DEFECTS?
E.B.
SamrÃn, C.M. van Duijn, G.C.M.L. Christiaens, A. Hofman, and D.
Lindhout, Department of Clinical Genetics, University Hospital Rotterdam,
Rotterdam, The Netherlands; Department of Epidemiology & Biostatistics,
Erasmus University Medical School, Rotterdam, The Netherlands; MGC-Department
of Clinical Genetics, Erasmus University Rotterdam, Rotterdam, The
Netherlands; Department of Gynaecology and Obstetrics, University
Medical Centre Utrecht, Utrecht, The Netherlands
|
|
1:15
– 1:30 pm
|
IS
CARBAMAZEPINE ADMINISTRATION DURING PREGNANCY TERATOGENIC? A PROSPECTIVE
CONTROLLED STUDY ON PREGNANCY OUTCOMES IN 229 EXPOSED WOMEN
A.
Ornoy, S. Shechtman, J. Arnon and O. Diav-Citrin, The Israeli Teratogen
Information Service; the Hebrew University Hadassah Medical School;
Israel Ministry of Health, Jerusalem, Israel.
|
|
1:30
– 1:45 pm
|
PREGNANCY
OUTCOME FOLLOWING GESTATIONAL EXPOSURE TO METRONIDAZOLE: A PROSPECTIVE
CONTROLLED COHORT STUDY
O.
Diav-Citrin, T. Gotteiner, S. Shechtman, J. Arnon, and A. Ornoy,
The Israeli Teratogen Information Service, the Hebrew University
Hadassah Medical School and Israel Ministry of Health, Jerusalem,
Israel
|
|
1:45
– 2:00 pm
|
FETAL
ABNORMALITIES ASSOCIATED WITH HIGH-DOSE TRANYLCYPROMINE IN TWO
CONSECUTIVE PREGNANCIES
D.S.
Kennedy, N. Evans, I. Wang, and W.S. Webster, Royal Prince Alfred
Hospital and The University of Sydney, Sydney, Australia
|
|
2:00
– 2:15 pm
|
MATERNAL
ALCOHOL CONSUMPTION AND INTRAUTERINE GROWTH RETARDATION: A POPULATION-BASED
CASE-CONTROL STUDY
Q.H.
Yang, B.B. Witkiewicz, R.S. Olney, Y.C. Liu, M. Davis, M.J. Khoury,
A. Correa, and J.D. Erickson, Centers for Disease Control and Prevention
(CDC), Atlanta, Georgia and Monroe County Department of Health,
Rochester, New York
|
|
2:15
– 2:30 pm
|
PROSPECTIVE
PREGNANCY OUTCOME IN WOMEN EXPOSED TO AMPHETAMINES
R.J.
Felix, C.D. Chambers, L.M. Dick, K.A. Johnson, and K.L. Jones, Department
of Pediatrics, Division of Dysmorphology and Teratology, University
of California San Diego, La Jolla, California
|
| |
|
Tuesday
2:30
pm–4:00 pm |
Platform
IIb: Teratology Society/OTIS Joint Session 2
Chairpersons: Kathie Johnson and Jan Freidman |
|
2:30
– 2:45 pm
|
DESIGN
OF A DATABASE OF HUMAN PRENATAL DRUG EXPOSURES ASSOCIATED WITH
ADVERSE DEVELOPMENTAL OUTCOMES REPORTED TO FDA
A.
Vega and S. Tabacova, CDER/FDA and NCTR/ FDA, Rockville, Maryland
|
|
2:45
– 3:00 pm
|
ACCUTANE‘
- EXPOSED PREGNANCIES
M.A.
Honein and L. J. Paulozzi, Centers for Disease Control and Prevention,
Atlanta, Georgia
|
|
3:00
– 3:15 pm
|
CONFIDENTIALITY
AND DISCLOSURE ISSUES IN COUNSELING PREGNANT PATIENTS WHO REVEAL
SUBSTANCE ABUSE: A CASE REPORT
K.
Filkins, S. Beverly, E. Chen, D Johnstone, J. Gordon, and N. Catalano,
UCLA School of Medicine, Department of Obstetrics and Gynecology,
Los Angeles, California; UCLA School of Medicine, Department of
Clinical Social Work, Los Angeles, California; California Teratogen
Information Service, University of California, San Diego Medical
Center
|
|
3:15
– 3:30 pm
|
DOES
DRUG LABELING INFLUENCE RISK PERCEPTIONS OF TERATOGENICITY? A
SURVEY OF PREGNANT WOMEN AND THEIR HEALTH PROFESSIONALS
A.
Einarson, M.Pole, T.R. Einarson, N. Pairadeau, and G. Koren, The
Motherisk Program, The Hospital for Sick Children, Faculty of Pharmacy,
University of Toronto, and Obstetrics Dept, North York General Hospital,
Toronto, Canada
|
|
3:30
– 4:00 pm
|
SELF-SELECTION
BIAS IN TERATOLOGY INFORMATION SERVICE PREGNANCY OUTCOME STUDIES
K.A.
Johnson, P.A. Weber, C.D. Chambers, and K.L. Jones, Department of
Pediatrics, Division of Dysmorphology and Teratology, University
of California San Diego, La Jolla, California and Kaiser Permanente
of Southern California, San Diego, California
|
| |
|
Tuesday
1:00 pm – 2:30 pm |
Platform IIIa: Hazard/Risk Assessment Session 1
Chairpersons: James Schardein and Patricia Bittner |
|
1:00
– 1:15 pm
|
DEVELOPMENTAL
TOXICITY INTERACTIONS OF METHANOL AND RADIOFREQUENCY (RF) RADIATION
OR 2-METHOXYETHANOL (2ME) IN RATS
B.K.
Nelson, D.L. Snyder, and P.B. Shaw, Division of Biomedical and Behavioral
Science, NIOSH, Cincinnati, Ohio
|
|
1:15
– 1:30 pm
|
ADDITIVITY
OF CARBON MONOXIDE AND PROTEIN DEFICIENCY ON NEONATAL MORTALITY
IN MICE
J.
Singh, Stillman College, Tuscaloosa, Alabama
|
|
1:30
– 1:45 pm
|
THE
PREDOMINANT ROLE OF MATERNAL TOXICITY IN LOVASTATIN-INDUCED DEVELOPMENTAL
TOXICITY
L.D.
Wise, M.A. Cukierski, G.R. Lankas, and G.L. Skiles, Merck Research
Laboratories, West Point, Pennsylvania
|
|
1:45
– 2:00 pm
|
PREGNANCY
ALTERS THE PHARMACOKINETICS OF CYSTEAMINE IN THE PREGNANT RAT
AND EFFECTS POSTNATAL DEVELOPMENT
L.B.
Fawcett, D.A. Beckman, L.K. Sherrell, J.E Pugarelli, and F.K Assadi,
Department of Medical Cell Biology, Alfred I. duPont Hospital for
Children, Wilmington, Delaware
|
|
2:00
– 2:15 pm
|
LEFLUNOMIDE
AS AN EXAMPLE OF A MODERN APPROACH TO PRODUCT LABELING FOR REPRODUCTIVE
EFFECTS: A CATEGORY X DRUG BASED ON PHARMACOKINETIC DATA
R.L.
Brent, duPont Hospital for Children, Wilmington, Delaware
|
|
2:15
– 2:30 pm
|
THE
EFFECTS OF IN UTERO EXPOSURE TO A
LOW DOSE OF BISPHENOL A ON FEMALE SEXUAL MATURATION OF THE RAT
C.E.
Talsness and I. Chahoud, Institute of Clinical Pharmacology and
Toxicology, Benjamin Franklin Medical Center, Freie Universitaet,
Berlin, Germany
|
| |
|
Tuesday
2:30 pm – 4:00 pm |
Platform IIIb: Hazard/Risk Assessment Session 2
Chairpersons: Ed Carney and Steve Harris |
|
2:30
– 2:45 pm
|
A
THREE-DIMENSIONAL CULTURE SYSTEM SUPPORTS DEVELOPMENT OF INCISORS
AND MOLARS IN MAXILLA AND MANDIBLE OF CULTURED MURINE FIRST ARCHES
P.
Williams, D. Montufar-Solis, and J. Duke, Dept. of Orthodontics,
Dental Branch, UT Houston Health Science Center, Houston, Texas
|
|
2:45
– 3:00 pm
|
THE
MECHANISM OF CLEFT PALATE FORMATION IN THE CHONDRODYSPLASIA MOUSE
W.
McLean, I.G. Lavrin, R.E. Seegmiller, C.W. Archer, E.D. Hay, and
B.R. Olsen, Harvard Medical School and Harvard School of Dental
Medicine, Boston, Massachusetts; Brigham Young University, Provo,
Utah; and Cardiff University, Cardiff, UK
|
|
3:00
– 3:15 pm
|
DEVELOPMENTAL
TOXICITY STUDIES WITH GLYPHOSATE AND SELECTED SURFACTANTS IN RATS
D.R.
Farmer, T.A Kaempfe, W.F. Heydens, and W.R. Kelce, Monsanto Company,
St. Louis, Missouri
|
|
3:15
– 3:30 pm
|
RIO
GRANDE RIVER WATER AND SEDIMENT EXTRACTS INDUCE NEURAL TUBE DEFECTS
(NTD) IN XENOPUS
D.J.
Fort, E.L. Stover, J.A. Bantle, and J.G. Burkhart, The Stover Group,
Stillwater, Oklahoma; Oklahoma State University Department of Zoology,
Stillwater, Oklahoma; NIEHS, Research Triangle Park, North Carolina
|
|
3:30
– 3:45 pm
|
MECHANISMS
FOR DEVELOPMENTAL TOXICITY OF TOMUDEX
C.
Lau, R.G. Hanson, D. Lui, M. L. Mole, M.G. Narotsky, J.M. Rogers
and R.M. Zucker, Reproductive Toxicology Division, NHEERL, USEPA,
Research Triangle Park, North Carolina
|
|
3:45
– 4:00 pm
|
MESOTRIONE:
IS MOUSE THE RELEVANT MODEL FOR HUMANS OF THE DEVELOPMENTAL AND
REPRODUCTIVE EFFECTS OF TYROSINE?
W.M.
Provan and R.W. Lewis, Zeneca Central Toxicology Laboratory, Macclesfield,
Cheshire, UK
|
| 4:00
pm – 10:00 pm |
Exhibits
Open |
| 4:30
pm – 6:00 pm |
Business
Meeting |
Tuesday
7:30 pm – 10:00 pm |
Poster
Session
Sponsored
by Covance Laboratories, Quintiles, SNBL, Springborn Laboratories,
Inc., and TherImmune Research Corporation
|
|
|
| |
| 7:30
am – 8:15 am |
Continental
Breakfast |
| 7:30
am – 5:00 pm |
Registration |
| 8:30
am – 12: 00 noon |
Public
Affairs Symposium:
What
Do We Know About the Reproductive & Developmental Risks of
Herbal and Alternate Remedies?
Chairpersons: Kenneth Jones and Harpal Buttar
|
|
8:30
– 8:45 am
|
INTRODUCTION
H.S.
Buttar, Bureau of Pharmaceutical Assessment, Health Protection Branch,
Ottawa, Canada
|
|
8:45
– 9:15 am
|
POTENTIAL
TOXICITIES OF HERBAL THERAPIES IN THE DEVELOPING FETUS
T.M.
Jurgens, College of Pharmacy, Dalhousie University, Halifax, Nova
Scotia, Canada
|
|
9:15
– 9:45 am
|
HERBAL
REMEDIES IN PREGNANCY - METHODOLOGICAL AND PRACTICAL ISSUE
G.
Koren, The Motherisk Program, Toronto, Ontario, Canada
|
|
9:45
– 10:15 am
|
INTERACTIONS
OF HERBAL AND ALTERNATE REMEDIES WITH CONVENTIONAL MEDICINES
B.A.
Buehler, University of Nebraska Medical Center, Omaha, Nebraska
|
Wednesday
10:15 am - 10:45 am |
WARKANY
TEA |
|
10:45
– 11:15 am
|
PREGNANCY
OUTCOME IN WOMEN USING HERBAL AND ALTERNATE THERAPIES
T.
Johns, School of Dietetics and Human Nutrition, McGill University,
Ste. Anne de Bellevue, Quebec, Canada
|
|
11:15
– 11:45 am
|
REGULATORY
ISSUES CONCERNING THE SAFETY AND EFFICACY OF HERBAL AND ALTERNATIVE
REMEDIES
C.G.
Rousseaux, Department of Cellular and Molecular Medicine, Faculty
of Medicine, University of Ottawa, Ontario, Canada
|
|
11:45
– 12:00 pm
|
DISCUSSION
K.
Jones, Department of Pediatrics, Division of Dysmorphology and Teratology,
University of California, San Diego, La Jolla, California
|
| |
|
Wednesday
1:00 pm–4:45 pm |
Workshop
I
Interpretation
of Data on Developmental Neurotoxicity
Chairpersons: Carole Kimmel and Deborah
Rice
|
|
1:00
– 1:10 pm
|
WORKSHOP
OVERVIEW
C.A.
Kimmel, USEPA, NCEA, Washington, District of Columbia
|
|
1:10
– 2:00 pm
|
NEUROBEHAVIORAL
DATA INTERPRETATION IN NEUROTOXICITY STUDIES: FOB, MOTOR ACTIVITY
AND FUNCTION
V.C.
Moser, USEPA, Research Triangle Park, North Carolina
|
|
2:00
– 2:50 pm
|
SENSORY
SYSTEM TESTING
L.D.
Fechter, University of Oklahoma Health Sciences Center, Oklahoma
City, Oklahoma
|
|
2:50
– 3:40 pm
|
INTERPRETATION
OF TESTS OF COGNITIVE FUNCTION IN ANIMAL MODELS OF DEVELOPMENTAL
NEUROTOXICOLOGY
D.C.
Rice, NCEA, USEPA, Washington, District of Columbia
|
|
3:40
– 4:30 pm
|
ASSESSMENT
OF DEVELOPMENTAL NEUROTOXICITY IN HUMANS
D.C.
Bellinger, Children's Hospital, Boston, Massachusetts
|
|
4:30
– 4:45 pm
|
GENERAL
DISCUSSION |
| |
|
Wednesday
1:00 pm – 4:00 pm |
Workshop
II
Developmental
Toxicokinetics: Lessons for Product Development
Chairpersons: Rakesh Dixit and L. David Wise
|
|
1:00
– 1:10 pm
|
INTRODUCTION
R.
Dixit and L.D. Wise, Merck Research Laboratories, West Point, Pennsylvania
|
|
1:10
– 1:50 pm
|
ANATOMICAL
AND DEVELOPMENTAL ASPECTS OF MATERNAL-EMBRYONIC-FETAL INTERFACE
J.
DeSesso, Biomedical Research Institute, Mitretek Systems, McLean,
Virginia
|
|
1:50
– 2:10 pm
|
COMPARTMENTAL
AND PHYSIOLOGICALLY-BASED TOXICOKINETICS IN RISK ASSESSMENT
D.
Clarke, Lilly Research Laboratories, A Division of Eli Lilly &
Company, Greenfield, Indiana
|
|
2:10
– 2:30 pm
|
APPLICATIONS
AND LIMITATION OF DEVELOPMENTAL TOXICOKINETIC STUDIES: MECHANISTIC
VS. RISK ASSESSMENT
R.
Dixit, Department of Safety Assessment, Merck Research Laboratories
(MRL), Merck and Company, Inc., West Point, Pennsylvania
|
|
2:30
– 4:00 pm
|
CLINICAL
AND REGULATORY CONSIDERATIONS IN DEVELOPMENTAL TOXICOKINETICS
P.J.
Wier, Safety Assessment, SmithKline Beecham Pharmaceuticals, King
of Prussia, Pennsylvania
|
| |
|
Wednesday
1:00 pm - 4:00 pm |
Workshop
III
Teratology
Society's Ethics Code, Certification, Disclaimer Guidelines
and Expertise Recognition
Chairpersons: Robert L. Brent, Narsingh Agnish, and Anthony
R. Scialli
|
|
1:00
– 4:00 pm
|
OVERVIEW
R.L.
Brent, N. Agnish, and A.R. Sciali
du Pont Hospital for Children, Wilmington, Delaware, Hoffman-LaRoche
Inc., Nutley, New Jersey, and Georgetown University, Washington,
District of Columbia
|
Wednesday
4:00
pm – 5:00 pm |
Historical
Control Database Demonstration
Kok-Wah
Hew and L. David Wise
|
| 4:00
pm – 6:00 pm |
Council
II Meeting |
| 6:30
pm – 7:30 pm |
Banquet
Reception |
| 6:30
pm – 7:30 pm |
President's
Circle Reception (By Invitation Only) |
Wednesday
7:30
pm – 10:30 pm |
Banquet |
|
|
| |
| 7:30
am – 8:15 am |
Continental
Breakfast |
| 7:30
am – 5:00 pm |
Registration |
| 8:30
am–10:00 am |
Platform
IVa: Clinical Teratology
Chairpersons: Jeanne Manson and Lewis Holmes |
|
8:30
– 8:45 am
|
IDENTIFYING
CRITICAL WINDOWS OF EXPOSURE FOR CHILDREN'S HEALTH
S.G.
Selevan, C.A. Kimmel, and P. Mendola, USEPA, NCEA, Washington, DC,
and NHEERL, Research Triangle Park, North Carolina
|
|
8:45
– 9:00 am
|
CONGENITAL
LATERAL RECTUS DEFICITS AND ASSOCIATED MALFORMATIONS AND SYNDROMES
M.T.
Miller and K. Str›mland, University of Illinois at Chicago, Department
of Ophthalmology, Chicago, Illinois; The Queen Silvia Children's
Hospital, Department of Pediatric Ophthalmology, G›teborg, Sweden
|
|
9:00
– 9:15 am
|
CHANGES
IN CRANIOFACIAL FEATURES IN CHILDREN EXPOSED TO ANTIEPILEPTIC
DRUGS IN UTERO
H.I.
Orup, Jr., B.A. Coull, J. Adams, L.M. Ryan and L.B. Holmes. Genetics
and Teratology Unit, Pediatric Service, Massachusetts General Hospital;
Department of Biostatistics, Harvard School of Public Health; and
Department of Psychology, University of Massachusetts, Boston, Massachusetts
|
|
9:15
– 9:30 am
|
THE
CHILDREN OF THE SWEDES WITH THALIDOMIDE EMBRYOPATHY
K.
Str›mland, M. Andersson Gr›nlund, and E. Philipsson, The Queen Silvia
Children's Hospital, Department of Pediatric Ophthalmology,
G›teborg University, G›teborg, Sweden
|
|
9:30
– 9:45 am
|
SURVIVAL
OF INFANTS WITH SPINA BIFIDA AND ENCEPHALOCELE: A POPULATION STUDY,
1979-1994
L-Y.C.
Wong and L. Paulozzi, Centers for Disease Control and Prevention,
Atlanta, Georgia
|
|
9:45
– 10:00 am
|
NONGENITAL
MALFORMATIONS AND EXPOSURE TO PROGESTATIONAL DRUGS DURING PREGNANCY:
THE FINAL CHAPTER OF AN ERRONEOUS ALLEGATION
R.L.
Brent, duPont Hospital for Children, Wilmington, Delaware
|
| |
|
Thursday
10:00 am–11:45 am |
Platform
IVb: Epidemiology
Chairperson: Joe Lary |
|
10:00
– 10:15 am
|
GENOTYPES
OF HOXA1
AND HOXB1
AND GENDER: SUSCEPTIBILITY TO AUTISM SPECTRUM DISORDERS
P.M.
Rodier, C.J. Stodgell, L.W. Weitkamp, J.L. Ingram, S.L. Hyman, and
D.A. Figlewicz, Departments of OB/GYN, Psychiatry, Pediatrics, and
Neurology, University of Rochester, Rochester, New York
|
|
10:15
– 10:30 am
|
MATERNAL
AND FETAL GENOTYPIC EFFECTS: TRANSFORMING GROWTH FACTOR ALPHA
AND ORAL CLEFTS AS AN EXAMPLE OF A NEW PARADIGM
D.F.
Wyszynski, T. Wu, M.H. Khoshnevisan, A. Miller-Chisholm, M. Mazaheri,
R.E. Long Jr., and S.R. Diehl, Boston University School of Medicine,
Boston, Massachusetts; NIDCR, NIH, Bethesda, Maryland; Lancaster
Cleft Palate Clinic, Lancaster, Pennsylvania
|
|
10:30
– 10:45 am
|
TRANSFORMING
GROWTH FACTOR BETA 3 AND OROFACIAL CLEFTS
P.A.
Romitti, A.C. Lidral, J.C. Murray, S. Daack-Hirsch, and T.L. Burns,
University of Iowa, Iowa City, Iowa
|
|
10:45
– 11:00 am
|
GASTROSCHISIS
PREVALENCE RATES: NO SECULAR TRENDS IN CALIFORNIA, FROM 1984 TO
1996
C.P.
Torfs and K. Deosaransingh, California Birth Defects Monitoring
Program, Emeryville, California
|
|
11:00
– 11:15 am
|
LOWERED
WEIGHT GAIN DURING PREGNANCY AND RISK OF NEURAL TUBE DEFECTS AMONG
OFFSPRING
G.M.
Shaw, K. Todoroff, S.L. Carmichael, D.M. Schaffer, and S. Selvin,
California Birth Defects Monitoring Program, Emeryville, California
|
|
11:15
– 11:30 am
|
PERICONCEPTIONAL
INTAKE OF VITAMIN SUPPLEMENTS AND RISK OF MULTIPLE CONGENITAL
ANOMALIES
G.M.
Shaw, L.A. Croen, K. Todoroff, and M.M. Tolarova, California Birth
Defects Monitoring Program, Emeryville, California
|
|
11:30
– 11:45 am
|
EVALUATION
OF MARKERS FOR EARLY DETECTION OF PREGNANCY IN AN AUTOMATED DATABASE
J.
Manson, B. McFarland, S. Weiss, C. Corelle, University of Pennsylvania,
Philadelphia, Pennsylvania; Kaiser Permanente Center for Health
Research, Portland, Oregon; University of Maryland, Baltimore, Maryland
|
| |
|
Thursday
9:00 am–10:15 am |
Platform
Va: Modes of Action Session 1
Chairpersons: Dana Shuey and Neil Chernoff |
|
9:00
– 9:15 am
|
EFFECTS
OF VLA-4 ANTAGONISTS IN RAT WHOLE EMBRYO CULTURE
S.
Spence, C. Vetter, W. Hagmann, R. Mumford, G. Van Riper, H. Williams,
and J. Schmidt, Developmental & Reproductive Toxicology, Medicinal
Chemistry, Pharmacology & Inflammation Research, Merck Research
Labs, West Point, Pennsylvania
|
|
9:15
– 9:30 am
|
ACTIVATION
OF CASPASE-9 IN DAY 9 MOUSE EMBRYOS EXPOSED IN
VITRO TO HYPERTHERMIA, 4-HYDROPEROXYCYCLO-
PHOSPHAMIDE, AND STAUROSPORINE
S.A.
Little and P.E. Mirkes, Department of Pediatrics, University of
Washington, Seattle, Washington
|
|
9:30
– 9:45 am
|
ANTIOXIDANT
AMELIORATION OF ARSENICAL-INDUCED EFFECTS IN
VIVO
E.S.
Hunter and E.H. Rogers, Reproductive Toxicology Division, NHEERL,
USEPA, Research Triangle Park, North Carolina
|
|
9:45
– 10:00 am
|
EFFECTS
OF TROGLITAZONE AND AMINOGLUTETHIMIDE ON RAT PLACENTAL AND FETAL
WEIGHTS
P.J.
Wier, E.A. Zahalka, S. Rehm, R. Kuk, A. Nix, and S. Murzyn, Safety
Assessment, SmithKline Beecham Pharmaceuticals, King of Prussia,
Pennsylvania
|
|
10:00
– 10:15 am
|
HOMOCYSTEINE
THIOLACTONE DOES NOT PRODUCE NEURAL TUBE DEFECTS IN MOUSE EMBRYOS
IN
VITRO
D.K.
Hansen, T.F. Grafton, S. Melnyk and S.J. James, National Center
for Toxicological Research, Jefferson, Arkansas
|
| |
|
Thursday
10:15 am–11:30 am |
Platform
Vb: Modes of Action Session 2
Chairpersons: Stan Spence and Cathy Price |
|
10:15
– 10:30 am
|
COMPARATIVE
DEVELOPMENTAL TOXICITY OF THE GLYCOL ETHER METABOLITES, METHOXYACETIC
ACID AND METHOXYPROPIONIC ACID
E.W.
Carney and K.A. Johnson, The Dow Chemical Company, Midland, Michigan
|
|
10:30
– 10:45 am
|
INHIBITION
OF NEURAL CREST CELL MIGRATION BY THE WATER DISINFECTION BYPRODUCT
BROMOCHLORO ACETIC ACID
J.E.
Andrews, H. Nichols, J. Schmid, G. Klinefelter and E.S. Hunter,
Reproductive Toxicology Division and Research Support Division,
NHEERL, USEPA, Research Triangle Park, North Carolina
|
|
10:45
– 11:00 am
|
Cu
DEFICIENCY ALTERS CARDIOVASCULAR STRUCTURE AND EXTRACELLULAR MATRIX
(ECM) PROTEIN EXPRESSION DURING MURINE DEVELOPMENT
L.
Lanoue, M.E. Beckers, T.E. Landerholm, R.B. Rucker, C.L. Keen and
J.Y. Uriu-Adams, Nutrition Dept., University of California at Davis,
Davis, California
|
|
11:00
– 11:15 am
|
THE
TOXIC MECHANISM OF ALLANTOIC AGENESIS IN DCF TREATED EARLY POSTIMPLANTATION
MOUSE EMBRYOS
M.J.
Airhart, T.E. Kwasigroch, and R.G. Skalko, Department of Anatomy
and Cell Biology, East Tennessee State University, Johnson City,
Tennessee
|
|
11:15
– 11:30 am
|
MICROARRAY
ANALYSIS OF ALTERED GENE EXPRESSION IN THE TESTES OF FETAL RATS
EXPOSED TO DBP
V.D.
Shultz, S.L. Phillips, P.M.D. Foster, and K.W. Gaido, CIIT, Research
Triangle Park, North Carolina
|
Thursday
12:00
noon – 1:00 pm |
James G. Wilson and F. Clarke Fraser Awards Luncheon |
| Instructions
for Presentations and Posters |
|
Oral Presentations
Each platform paper, except for those presented in the symposia, will
be allowed 15 minutes (12 minutes for presentations and 3 minutes for
discussion). The time schedule will be strictly followed. Projectors for
35 mm slides will be available in each meeting room. Please keep slides
simple and uncluttered.
A good rule of thumb is, if you cannot read your slide without magnification,
those in the middle and rear of the room will be unable to read it when
presented. One concept per slide and a maximum rate of one slide per minute,
are also good rules to follow for effective presentations.
Poster
Presentations
Poster material should be organized within a 4 ft. x 8 ft. area. The
top of your poster board should contain the following information, with
letters at least 3/4 inches high:
- Your poster
number
- Title
- Authors
- Affiliations
A copy of
the abstract should be posted towards the upper-left corner, and a set
of conclusions toward the lower- right corner of your poster. These should
be printed in letters about 1/4 inch high. Poster information should be
legible from a distance of at least 3 to 4 feet. Material, including line
drawings, should be clearly presented and may be computer generated (laser
printer is preferable). PLEASE BRING YOUR OWN PUSH-PINS. Poster sessions
and times for setup and removal are indicated in the Program.
Posters should be on display from 11:00 AM - 10:00 PM on Monday, June
26, or 11:00 AM - 10:00 PM on Tuesday, June 27. Those presenting should
plan to be present on Monday or Tuesday evenings from 7:30 PM - 10:00
PM. All posters should be removed immediately following the poster session
at which you presented (10:00 PM).
| Continuing
Education Course |
|
SIGNAL
TRANSDUCTION:
Pathways to Growth, Differentiation, and Morphogenesis
This year's
Continuing Education Course will focus on signal transduction and the
role of selected cellular signaling pathways in morphogenesis. The course
lectures will be presented in sequence focusing on signal transduction
from the outside of the cell (extracellular matrix and cell adhesion molecules),
to the plasma membrane (growth factor receptors and heterotrimeric G proteins),
cytoplasm (protein kinases), and nucleus (nuclear receptors and transcription
factors). Each lecturer will review a selected signal transduction pathway
and its role in normal and abnormal development as demonstrated by the
use of specific inhibitors of the pathway, genetic mutations, and/or animal
models such as knockouts.
In addition to the cell surface to nuclear review of cellular signaling
outlined above, three signal transduction pathways known to play significant
roles in development have been selected for review and discussion. The
three pathways are vascular endothelial growth factor mediated signaling,
the endothelin receptor mediated pathway, and peroxisome proliferator-activated
receptor mediated signaling. This year's course will provide an overview
of the field of signal transduction and the highlight importance of this
field of research for Teratologists.
Saturday,
June 24, 2000
| 1:00
– 1:05 |
Welcome
– George Daston, President, Teratology Society |
| |
|
| 1:05
– 1:10 |
Introduction
– JoLynda Jones, Bristol-Myers Squibb |
| |
|
| 1:15
– 2:00 |
CELL
ADHESION MOLECULES AND SIGNAL TRANSDUCTION: BIDIRECTIONAL INTERFACE
FOR REGULATION OF DEVELOPMENT
SPEAKER: Gerald Grunwald, Thomas Jefferson University |
| |
|
| 2:00
– 2:45 |
TRANSFORMING
GROWTH FACTORS-ã : IMPORTANT MEDIATORS OF MAMMALIAN DEVELOPMENT
SPEAKER: Kathy Flanders, National Cancer Institute |
| |
|
| 2:45
– 3:30 |
G
PROTEINS: MASTER SWITCHES IN CELLULAR SIGNAL TRANSDUCTION
SPEAKER: Cynthia Ward, University of Pennsylvania |
| |
|
| 3:30
– 3:45 |
COFFEE
BREAK |
| |
|
| 3:45
– 4:30 |
PROTEIN
KINASE C
SPEAKER: Sidney Hunter, US Environmental Protection Agency |
| |
|
| 4:40
– 5:15 |
RETINOIDS
SIGNALING AND EMBRYOGENESIS
SPEAKER: Devendra Kochhar, Thomas Jefferson University |
Sunday, June 25, 2000
| 7:30
– 8:15 |
CONTINENTAL
BREAKFAST |
| |
|
| 8:15
– 9:00 |
SIGNAL
TRANSDUCTION PATHWAYS REGULATING CELL DEATH (APOPTOSIS) OR CELL SURVIVAL
SPEAKER: Philip E. Mirkes, University of Washington |
| |
|
| 9:00
– 9:45 |
VASCULOGENESIS
AND ANGIOGENESIS: A CRITICAL GENE PATHWAY FOR EMBRYONIC DEVELOPMENT
SPEAKER: Barbara Abbott, US Environmental Protection Agency |
| |
|
| 9:45
– 10:15 |
COFFEE
BREAK |
| |
|
| 10:15
– 11:00 |
ENDOTHELIN
SPEAKER: Deepak Srivastava, University of Texas Southwestern Medical
Center |
| |
|
| 11:00
– 11:45 |
ROLES
OF THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPARs) IN DEVELOPMENT
SPEAKER: Jeffrey M. Peters, Pennsylvania State University |
| |
|
| 11:45
– 12:00 |
DISCUSSION
/ ADJOURNMENT |
(As of April
1, 2000)
The
Teratology Society thanks the following organizations for their participation
as exhibitors at the 2000 Annual Meeting in Palm Beach, Florida.
| Clinical
Trials BioResearch, Ltd. |
ISIS
BioComp |
| Elsevier
Science, Inc. |
John
Wiley & Sons, Inc. |
| EMBI
TEC |
San
Diego Instruments, Inc. |
| Hamilton-Kinder |
Sierra
Biomedical, Inc. |
| Hamilton
Thorne Research |
SNBL
USA, Ltd. |
| Huntingdon
Life Sciences |
TherImmune
Research Corporation |
| IIT
Research Institute |
Toxicology
Research Laboratory |
| Instem
Life Sciences, Ltd. |
|
| 2000
President's Circle Contributors |
|
The
Teratology Society thanks the following organizations
for their generous support of the Teratology Society.
Aventis
Bayer Corporation
Chevron Corporation
Coca-Cola Company
Eastman Kodak Company
Glaxo Wellcome
Hoffmann-La Roche, Inc.
Huntingdon Life Sciences
Merck Research Laboratories
Pfizer, Inc.
Primedica Argus Research Laboratories, Inc.
Sanofii-Synthelabo Research
Schering-Plough Research
SmithKline Beecham Pharmaceuticals
Springborn Laboratories, Inc.
Valent U.S.A. Corporation
WIL Research Laboratories, Inc.
Sustaining
Members
American Petroleum Institute
Bristol-Meyers Squibb Company
ClinTrials BioResearch, Ltd., (CTBR)
Covance Laboratories
Dow Corning Corporation
Eli Lilly and Company
Exxon Mobil Biomedical Sciences
Mitretek Systems
Pharmacia & Upjohn, Inc.
Procter & Gamble Company
R.W. Johnson Pharmaceutical Research Institute, Ltd.
Warner Lambert Company
Wyeth-Ayerst Research
2000
Annual Meeting Sponsors
The
Teratology Society thanks the following year 2000 Sponsors
(As of April 18, 2000)
Aventis
Covance Laboratories, Inc.
Eli Lilly & Company
Elsevier Science, Inc.
John Wiley & Sons
March of Dimes
Merck Research Laboratories
Middle Atlantic Reproduction and
Teratology Association
Midwest Teratology Association
Pfizer, Inc.
Primedica Argus Research Laboratories, Inc.
Proctor & Gamble Company
Quintiles Toxicology/Pathology
SNBL USA, Ltd.
Springborn Laboratories, Inc.
TherImmune Research Corporation
WIL Research Laboratories
rev. 10-Jun-2003
© Copyright Teratology Society 1998-2002,
2003.
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